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gcvT from Brucella melitensis biovar Abortus 2308

Victor ID 1768
Gene Name gcvT from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3828234
NCBI Protein GI 83269412
Locus Tag BAB2_0513
Protein Accession YP_418703.1
Other Database IDs UniProtKB-ID: Q2YKY1_BRUA2
UniRef100: UniRef100_B2SAU3
UniRef90: UniRef90_A9MC13
UniRef50: UniRef50_A1UTQ5
UniParc: UPI00004F9343
EMBL: AM040265
EMBL-CDS: CAJ12679.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0513
eggNOG: COG0404
HOGENOM: HBG299834
OMA: FGAFAGW
ProtClustDB: PRK13579
BioCyc: BMEL359391:BAB2_0513-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 503731
Gene Ending Position 505062
Gene Strand (Orientation) +
Protein Name Glycine cleavage T protein (aminomethyl transferase)
DNA Sequence 
>gi|83268957:503731-505062 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
CTGTTTGCGGGAGAGAGCCGTTAAGGCCGCCGAAGGGGAAAACGCCCGAAATCTCTCAGGTACAAGGAAC
CGCAGGCGGGTAAGACAACTCTGGAAAGTCGGGGGCAACTCCGCGCCGAAGGTGTAAGTATGGCTTTATA
TATAGCCATGCGAGTCTCTCAGGCCTGAGACAGAGGGGCACGAACCAACCGCATTTTGCGGAAGGCATAC
GTGCGTCTCTGGAGTTGTTATGGGCGATACCGCACATTTGAATACCCTGCCGTTGCAGGATCTGCATGAA
AAGGCTGGCGCGCGCTTCGGCGGCTTTGCCGGCTGGAACATGCCAATCACCTATCCGCTGGGTGTGATGA
AGGAACATCTTCATACGCGCGACCATGCGGGCCTCTTCGACATTTCCCACATGAAGCTGGTGGAAGTTTC
CGGCGCGGATGCCGCCGCGCTTCTCGCCGAGACCTGCCCGCTCGATCCGACGATCCTGAAGACGGGCCAG
TCGAAATATACGTTCTTCCTCAATGATAATGGCGGCGTGCTGGATGATCTCATCGTCACGCGCCTTGGCG
AAGACCGTTTCATGGTTGTTGCCAATGCGGGCAATGCCGATGCCGACATCGAGCATCTCAATGAAGCCGC
GTCGGGCAAGGCCGTAAAGGTTAATCCGCTCGACCGTGTTTTCCTTGCTTTGCAGGGGCCGGAAGCAAAA
GCTGTCATCACCGATGCCGGTCTGCCGGGCGCCGATCTTGCCTTCATGAGCGGTTTCGAGCCGAAACAGG
GCTGGTTCATGACCCGTTCGGGCTATACCGGCGAAGACGGTTTCGAGATTGGCCTGCCTGCCGATGAAGC
CCGTGCGCTGGCCGAAAAGCTTCTTGCCGATGAACGTGTCGAATGGATCGGCCTTGCCGCCCGCGATTCC
TTACGCCTCGAAGCGGGCCTCTGCCTGCACGGTCAGGACATCACGCCGGAAACCGATCCGGTTTCGGCTG
GCCTCACCTGGGCGATCACCAAGGCTGTGCGCGAAAAAGCCGCCTTCAACGGCGCGAAAGCCGTTCTCGA
CGCCATTGCCAAAGGCGCCAGCGCCAAGCGCGTCGGCCTCAAGCCGGAAGGCCGCCAGCCGGTGCGCGCC
GGGGCCGACCTTTTCGACGAAAGTGGCCGCCAGATCGGCACCGTCACCTCGGGCGGCTTTGGCCCTTCCG
CCGGTTTCCCGGTCGCCATGGGCTATGTCGAGGCAAGCCTCGCCACCCCCGGCACCCGTGTTTTTGCAGA
TGTTCGCGGCAACAAGGTTCCCGTTGACGTCCACGCACTTCCCTTCACACCGCATCGCTATCGCAAAGGA
TG
Protein Sequence 
>gi|83269412|ref|YP_418703.1| glycine cleavage system aminomethyltransferase T [Brucella abortus 2308] MGDTAHLNTLPLQDLHEKAGARFGGFAGWNMPITYPLGVMKEHLHTRDHAGLFDISHMKLVEVSGADAAALLAETCPLDPTILKTGQSKYTFFLNDNGGVLDDLIVTRLGEDRFMVVANAGNADADIEHLNEAASGKAVKVNPLDRVFLALQGPEAKAVITDAGLPGADLAFMSGFEPKQGWFMTRSGYTGEDGFEIGLPADEARALAEKLLADERVEWIGLAARDSLRLEAGLCLHGQDITPETDPVSAGLTWAITKAVREKAAFNGAKAVLDAIAKGASAKRVGLKPEGRQPVRAGADLFDESGRQIGTVTSGGFGPSAGFPVAMGYVEASLATPGTRVFADVRGNKVPVDVHALPFTPHRYRKG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis gcvT gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0404E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].