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gcvP from Brucella melitensis biovar Abortus 2308

Victor ID 1767
Gene Name gcvP from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3828233
NCBI Protein GI 83269414
Locus Tag BAB2_0515
Protein Accession YP_418705.1
Other Database IDs UniProtKB-ID: GCSP_BRUA2
UniRef100: UniRef100_B2SAU5
UniRef90: UniRef90_B2SAU5
UniRef50: UniRef50_Q28L73
UniParc: UPI00004F9344
EMBL: AM040265
EMBL-CDS: CAJ12681.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0515
eggNOG: COG1003
HOGENOM: HBG286723
OMA: PETIMIE
ProtClustDB: PRK05367
BioCyc: BMEL359391:BAB2_0515-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 505441
Gene Ending Position 508239
Gene Strand (Orientation) +
Protein Name glycine dehydrogenase
DNA Sequence 
>gi|83268957:505441-508239 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
AATGACCGAATTTCTTCCCTTTGTGGCCCGCCATATCGGGCCGAGACATGAAGACGAGCGCGCCATGCTG
GCAGCGCTCGGCCTTCCTTCCATGGAAACCCTCATAACGCAGGCGGTTCCGGCCCCCATTCGCCTCAACC
GCGCGCTGAACCTGCCAGCGGCGCTCAGCGAAGCGGACGCACTTGCGGAACTGGGCACGATCATGGGCCG
CAACGTGGTGAAGAAGAGCTTCATCGGCGCGGGCTATCACGGTGTTCACACGCCGCCGGTCATCCAGCGC
AACCTGTTTGAAAACCCGGCCTGGTACACGGCTTATACGCCCTACCAGTCGGAAATCAGCCAGGGCCGCC
TTGAGCTTCTGTTCCACTTCCAGACACTGGTTGCCGAACTGACCGGCCTGCCGGTTGCCTGTGCCTCGCT
GCTCGACGAGGCGACTGCCGTTGCCGAAGCCATCGGCGTTGCCTGCCGCCATCATCGCGACAAGCGCAGC
CGCATTTTGCTTGCTGGCGAACTGCATCCGCAGACGGTCGATGTGGTGAACACCCGCGCTGAACCGCTCG
GCTGGGAGATCGCCACCGGCAGCGATGTTGACGACAACACCGCCGCAATCGTGGTTCCATGGCCGGATAC
GCGCGGCGTCTATGGCGATTTTGCCAAGGTCATTGCCGATGCCAAGGCCAAGGGCGCGCTGGTTATCGCC
GTTGCCGATCCGCTGGCGCTCACCATCATGGAAGCGCCTGCCAGGTGGGGCGCGGACATGGCCGTCGGCT
CCATGCAGCGCTATGGCGTGCCGATGGGCTTTGGCGGCCCGCACGCGGCTTATCTTGCAGTGTCCGAGGC
GCTCACTCGCATTATTCCGGGCCGCATCGTCGGCCAGTCGGTCGATGCGCATGGCCGCGCGGCCTATCGT
CTGGCGCTCCAGACCCGCGAGCAGCACATCCGCCGCGACAAGGCGACCTCCAATATCTGCACCGCGCAGG
CGCTTCTGGCCAACATGGCCGCAGCTTTCGCCATCTGGCATGGCCCGGCTGGCTTGCAGGCGATTGCAAC
GCGCGTGGCCGCTCTGGCCGCCCGTTTTGCTGCCGCGCTCAAGGCTGCCGGTGTTGAAATTGCGGGCGAA
AGCCTGTTCGATACGGTAACGGCCAAGGTTCCGGGCAAAGCCGCGGCAATCGCAGCCGAAGCCGACAAGG
GCGGCCGCCTGATCCGCATCATCGATGCGGATACGGTCGGCGTCACTTTCGACGAAACCTCGACGGAAGA
GGATCTGACGGCCCTGGCATCGCTCTTCGGTGCGAAGCCGGTTGGCGGCGACACAGTTCTTGTTCCGGGC
AAGGAACGCGGGGAAGGTTTCCTCACGCAGGAAGTATTCCATTCACATCGTTCCGAAACCGAGATGATGC
GCTTCCTGCGTCGTCTGGCCGACAAGGATCTGGCGCTCGACCGCGCGATGATCCCGCTTGGTTCCTGCAC
GATGAAGCTCAATGCGGCGGCAGAAATGATGCCGGTGAGCTGGAATACGGTTGCAAACCTGCATCCTTTT
GCGCCTGCCGAGCAGGTGCAGGGTTATGCGAAAATGACTTCCGATCTGGAAGCATGGCTTTGCGAAATCA
CCGGTTTTGCGGGCGTTTCATTGCAGCCAAATGCCGGTAGTCAGGGTGAATATGCCGGCCTTATGGCCAT
CCGCCACTATCATCAGGCGCGGGGGCAGGGCCATCGCAACATCTGCCTTATCCCGTCCTCGGCGCATGGC
ACCAATCCGGCCAGCGCCTCCATGGCGGGCATGAGCGTCGTCGTCGTCAATTGCCGCCCGGATGGCGACA
TCGATATTGATGATCTCAAGGCCAAGGCGGAAAAGCATCGCGATAATCTCGCCGCCTTCATGATTACCTA
TCCGTCCACCTATGGCGTGTTCGAGGAAGGCATCAAAGCCTTCTGCGAGATTGTGCATGACAATGGCGGC
CAGGTCTATTTCGACGGCGCGAACCTCAATGCGCTTGTCGGTCTGGCGCGGCCTGCCGATATCGGCGCGG
ACGTCTGCCACATGAATCTGCACAAGACCTTCTGCATCCCGCATGGCGGCGGTGGTCCGGGTGTTGGCCC
GATTGGCGTGGCGAAACATCTGGTGCCTTATCTGCCGGGCCATGTGGAAGCCGGTTCCGAACACGCTGTT
GCCGCAGCGCAGTTCGGCAGCGCATCCATTCTGGTCATTACGTGGATGTATATCCGCATGATGGGCGGGG
CCGGTTTGAAGAAGGCGACGGAAGCTGCAATCCTCAATGCCAATTATATTGCGCATCGTCTGAAGGGTGT
TTACCCGATCCTTTATACCGGCGCGCATGACCGCGTGGCGCATGAATGCATCGTGGATACGCGCGTATTG
AAGGACAGTGCGGGCATTACCGTGGAAGACGTGGCCAAGCGCCTGATCGACTATGGTTTCCATGCGCCGA
CCATGTCATGGCCGGTTGCCGGAACGCTGATGATCGAGCCGACCGAGTCCGAGCCCAAGCTGGAGATCGA
CCGTCTTTGCGATGCGATGATCGCGATTGCAGGCGAGGCGAAGAAGGTTGCCGATGGCGTCTGGCCTGCG
GATGACAATCCGCTTGCCAATGCGCCGCATACGGCGAGCGATACGCTGGCAACGGAATGGAAGCATCCCT
ATACCCGTGAGGAAGCCGTATTCCCCGGCGGTGCTTTCGATCCGACGGCAAAATATTGGCCGCCGGTCAG
CCGCGTGGATAATGTCGGCGGCGACCGGAACCTCATCTGCTCCTGCCCGCCTGTCGCAACCTATGGCTG
Protein Sequence 
>gi|83269414|ref|YP_418705.1| glycine dehydrogenase [Brucella abortus 2308] MTEFLPFVARHIGPRHEDERAMLAALGLPSMETLITQAVPAPIRLNRALNLPAALSEADALAELGTIMGRNVVKKSFIGAGYHGVHTPPVIQRNLFENPAWYTAYTPYQSEISQGRLELLFHFQTLVAELTGLPVACASLLDEATAVAEAIGVACRHHRDKRSRILLAGELHPQTVDVVNTRAEPLGWEIATGSDVDDNTAAIVVPWPDTRGVYGDFAKVIADAKAKGALVIAVADPLALTIMEAPARWGADMAVGSMQRYGVPMGFGGPHAAYLAVSEALTRIIPGRIVGQSVDAHGRAAYRLALQTREQHIRRDKATSNICTAQALLANMAAAFAIWHGPAGLQAIATRVAALAARFAAALKAAGVEIAGESLFDTVTAKVPGKAAAIAAEADKGGRLIRIIDADTVGVTFDETSTEEDLTALASLFGAKPVGGDTVLVPGKERGEGFLTQEVFHSHRSETEMMRFLRRLADKDLALDRAMIPLGSCTMKLNAAAEMMPVSWNTVANLHPFAPAEQVQGYAKMTSDLEAWLCEITGFAGVSLQPNAGSQGEYAGLMAIRHYHQARGQGHRNICLIPSSAHGTNPASASMAGMSVVVVNCRPDGDIDIDDLKAKAEKHRDNLAAFMITYPSTYGVFEEGIKAFCEIVHDNGGQVYFDGANLNALVGLARPADIGADVCHMNLHKTFCIPHGGGGPGVGPIGVAKHLVPYLPGHVEAGSEHAVAAAQFGSASILVITWMYIRMMGGAGLKKATEAAILNANYIAHRLKGVYPILYTGAHDRVAHECIVDTRVLKDSAGITVEDVAKRLIDYGFHAPTMSWPVAGTLMIEPTESEPKLEIDRLCDAMIAIAGEAKKVADGVWPADDNPLANAPHTASDTLATEWKHPYTREEAVFPGGAFDPTAKYWPPVSRVDNVGGDRNLICSCPPVATYG
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity)(UniProt: Q8FVU9).

CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2)(UniProt: Q8FVU9).

COFACTOR: Pyridoxal phosphate (By similarity)(UniProt: Q8FVU9).

SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity)(UniProt: Q8FVU9).

SIMILARITY: Belongs to the gcvP family(UniProt: Q8FVU9).

MUTATION: gcvP encodes for glycine dehydrogenase and is required for persistent infection in mouse model (Ficht, 2003).
COG COG1003E, under E: Amino acid transport and metabolism
References
Ficht, 2003: Ficht TA. Intracellular survival of Brucella: defining the link with persistence. Veterinary microbiology. 2003; 92(3); 213-223. [PubMed: 12523983].