Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

fliF from Brucella melitensis biovar Abortus 2308

Victor ID 1766
Gene Name fliF from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3828220
NCBI Protein GI 83269941
Locus Tag BAB2_1105
Protein Accession YP_419232.1
Other Database IDs UniProtKB-ID: Q2YJF2_BRUA2
UniRef100: UniRef100_Q8FUS3
UniRef90: UniRef90_O52069
UniRef50: UniRef50_O52069
UniParc: UPI00000DDB72
EMBL: AM040265
EMBL-CDS: CAJ13271.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_1105
eggNOG: COG1766
HOGENOM: HBG661951
OMA: MQEVTRV
ProtClustDB: PRK06007
BioCyc: BMEL359391:BAB2_1105-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 1084008
Gene Ending Position 1085750
Gene Strand (Orientation) -
Protein Name flagellar MS-ring protein
DNA Sequence 
>gi|83268957:1084008-1085750 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
CTCAGGCCGCCTTCAGCTCCGGCATGGCCGATGCCTTCGCCGGGTCGGCCTCACGGCCCGAAGCGGTTTC
GTGAATCCATTGCTTGAGAACGGCAGCAACACGCTCTTCATCCATTTCGATCATCTGTTCGAGCCTGAGC
TTGGCCGGCATACGCATACGCTGGCGCAGATCGCTAAGGCTCGTCTTCATCTGATCGGCATAGGCCGCAG
GACCGCCAATGACGGCCTGAACACCTTCGCCCACGCTTTCCGCGCCGCCGATAAAATTCGGCGTCGCGAC
CTCACCCGCCTCACGGATAGCGACTTCCGTACCCGCGGGCTTCACATTCTGGTCACGCAATAGCGGGCGC
AGGCCAAACCAGATCAGAAGGCCGACGGCGGCAAGAATGGCAAGCGCATTGGCATAGCTTCCACTCTGAC
GAAGAAGCGTATCGGTCCACGGTGCGGAAACAGGCTCCATATCCGCACCGGCAGGGTCAAGGAAATTGAC
CGCCGTGACGTTGATGACATCGCCGCGATTGGTATTGAGACCAGCGGCGGTGGCGACGAGATCGCGAATC
TTCGTAATCTGCTGGTCCACGAAATTGGCGGGTGGGGGTGTGGTGCCAGCGGTCTGCAACAGGCGTGCCT
GATCGATGACGACGGCGATTGAAAGCCGCTTGATGCTATAGCCGTCACTGACGGTTGAAACCGTCTTGCT
GTTCACTTCATAATTGGTCAGTTCCTCACGGCGGTCCGTCTTTTCAGTCGAGCTTTCGCCGTTGCGGTTC
TGGATTTGCTCCTGCGGAATGTTCTGCTCCACACCCGTCGCATTATCATTGCGGTTGTTGCGGGAATCGC
CGCTTTCGCGCACCACACGGACGGAACGCTCCACGCGCGATTCGGGATCATAGGTAGTTTCCTTGGTCTG
GCGGCGGTCGGTGTCGAGCGCGGCCTGAACGGAAGTCTGGAAATGACCCAGGCCAAGATAGGGCGCAAGC
GCCTTGCGGATGCTGTCGTCCACATGGCTCGCAACCTGCTGTTCAAGCGACGCGGTCATGAGAGCCGCAC
CATTGGCCCCTTCGCCAGCCGATGCCAGCAGATGGCCATTTGTATCGAGCACCGTGACGGAAGACGCATC
GAGCGAGGGAACGGCAGCGGCGACCAGCTGGCGGATGGACTGGGCCGATTCAGCGGAAAATCCGCCTTCG
GCACGAATAACGACCGAGGCAGACGGCTTCTGGTCGCCGCGGCGGAACGAGCCTTTTTCGGCCAGAACGA
TGTGAACGCGCGCAGCCTTCACGCCGCGAATGGCCTGAATGGTACGGGCAATTTCTCCTTCGAGCGCGCG
CACACGGGTAATCTCCTGCATAAAGGACGTAAGCCCCAGCGACCCCATATTGTCGAACAGCTCATAACCG
GCATTGTTCGAGGTCGGCAGGCCCTTTTCGGCCAGATACATGCGGGCGTTTTCGGCCTTGCCGATTGGAA
CGAGGATCGAGGATCCATCAGACTTCACGTCGAAGGGAATGCCAGCTTCACCGAGCGCAAGGCCCATGCG
GTTCACGTCATCGCGCGAAAGGCCGACATAGAGCGTCTCGTAGGATGGGCGACCCAGATAGATGCTCGTA
TAGAGGATCGCACCCATCAAAGCCGCGCCTACAAGGCCGAGCGCGATGAGCTTTCGCGCACCAAGCTTGC
CGAGCGTTCCCTTGAGCTGTTCGATCAATTGCTGGAAATTCTGCTGCATCCACACCACCGCCA
Protein Sequence 
>gi|83269941|ref|YP_419232.1| flagellar MS-ring protein [Brucella abortus 2308] MAVVWMQQNFQQLIEQLKGTLGKLGARKLIALGLVGAALMGAILYTSIYLGRPSYETLYVGLSRDDVNRMGLALGEAGIPFDVKSDGSSILVPIGKAENARMYLAEKGLPTSNNAGYELFDNMGSLGLTSFMQEITRVRALEGEIARTIQAIRGVKAARVHIVLAEKGSFRRGDQKPSASVVIRAEGGFSAESAQSIRQLVAAAVPSLDASSVTVLDTNGHLLASAGEGANGAALMTASLEQQVASHVDDSIRKALAPYLGLGHFQTSVQAALDTDRRQTKETTYDPESRVERSVRVVRESGDSRNNRNDNATGVEQNIPQEQIQNRNGESSTEKTDRREELTNYEVNSKTVSTVSDGYSIKRLSIAVVIDQARLLQTAGTTPPPANFVDQQITKIRDLVATAAGLNTNRGDVINVTAVNFLDPAGADMEPVSAPWTDTLLRQSGSYANALAILAAVGLLIWFGLRPLLRDQNVKPAGTEVAIREAGEVATPNFIGGAESVGEGVQAVIGGPAAYADQMKTSLSDLRQRMRMPAKLRLEQMIEMDEERVAAVLKQWIHETASGREADPAKASAMPELKAA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The M ring may be actively involved in energy transduction (By similarity)(UniProt: Q8FUS3).

SUBUNIT: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity)(UniProt: Q8FUS3).

SUBCELLULAR LOCATION: Inner membrane; multi-pass membrane protein (By similarity)(UniProt: Q8FUS3).

SIMILARITY: Belongs to the fliF family(UniProt: Q8FUS3).

MUTATION: fliF is a gene potentially coding for the MS ring, a basal component of the flagellar system. Its mutant through signature- tagged mutagenesis is attenuated in vivo. It implicate a role for flagella in virulenc (Lestrate et al., 2003).
COG COG1766NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].