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cydB from Brucella melitensis biovar Abortus 2308

Victor ID 1762
Gene Name cydB from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3828142
NCBI Protein GI 83269608
Locus Tag BAB2_0727
Protein Accession YP_418899.1
Other Database IDs UniProtKB-ID: Q2YKD5_BRUA2
UniRef100: UniRef100_B2SBD5
UniRef90: UniRef90_D0B6V5
UniRef50: UniRef50_P26458
UniParc: UPI00000AF3F9
EMBL: AM040265
EMBL-CDS: CAJ12893.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0727
eggNOG: COG1294
HOGENOM: HBG413915
OMA: DLTIYNA
ProtClustDB: CLSK898928
BioCyc: BMEL359391:BAB2_0727-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 722411
Gene Ending Position 723565
Gene Strand (Orientation) -
Protein Name Beta and gamma crystallin:Cytochrome bd ubiquinol oxidase, subunit II
DNA Sequence 
>gi|83268957:722411-723565 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
ATCAGTAAGCGTGGTTGCTCTCATCCTCGATCATGCTCTTGTCCACCTTGCCCCAAAGGACCTTATAGAC
CCATGCGGTATAGGCGACGATGATCGGAATGAAGACGACCGTTACCACCAGCATGATGAACAGCGTCTGA
TGGCTGGACGATGAATCCCAGACCGTCAGGCTCGATTGCGGATCGATGGAAGACGGCAGGATGAACGGAA
ACATCGACACGCCGACAGACGAGATGATGCCGAAGATCGAGAGTTTTCCGAAGAGGAGCGGAGCAAGTTC
ACGACCGCCGCGTAGCGTTGCGAGAACCGCGAGCGCACCGAGAATGCCAAGCGCAGGCGCGATCAGCAGG
ATCGGATAATTCGCATAGTTCGCAAACCAGGCGCCGTGATCCAGTTCCACGGTCTTTTGCAGCGGGTTGG
AAGGCCCGTCCATCACCACCGCACTGGTTATGCGATACCCCGACACCCAAAGCCAGCTTATGGCACCGGC
GACGATGTAGAGAATGACGGTCAACAGCGCCGCAACGCTGCCATAGGCCCGCGCCCGCGCCTGTATCACG
CCATCTGTCTTCAAAACGAGCCATGCCGCGCCATGCATGGTGAGCATGGTGACGGACAGGATGCCGCACA
GAAGCGCAAACGGATTGAGCAGGCCGAAGAATGAGCCTTCGTAGAAGATCTGGAGATCGCCGTTGAGCCG
GAAGGGAACCCCCTGAAGCACATTTCCAACCGCCACGCCGAAGATCAGCGCCGGCACGAAGCCGCCGATG
AACAGCGCCCAGTCCCAACTGTTGCGCCAGGTTTCTCCATCACGCTTGGAGCGGAACTTGAAGCCGACCG
GGCGCAGGATGAGCGCGAACAGGATGACGAACATCGCCAGATAGAACCCGGAGAAGGACACCGCATAAAG
CGGCGGCCAGGCGGCGAAGATCGCACCGCCGCCAAGGATCAACCAGACCTGATTGCCTTCCCAGACGGGG
CCGATTGTATTGATGACGACGCGACGCTCCACATCGGTTCTGGCAACGAAAGGCAGAAACGTGCCGACGC
CGAGGTCGAAACCATCCATGGCGGCAAAGCCGATCAGCAGCACGCCGAGCAGCACCCACCAGATGATCCG
CAGGGTTTGATAGTCCAACAAATCGCTGAGTATCA
Protein Sequence 
>gi|83269608|ref|YP_418899.1| cytochrome bd ubiquinol oxidase subunit II [Brucella abortus 2308] MILSDLLDYQTLRIIWWVLLGVLLIGFAAMDGFDLGVGTFLPFVARTDVERRVVINTIGPVWEGNQVWLILGGGAIFAAWPPLYAVSFSGFYLAMFVILFALILRPVGFKFRSKRDGETWRNSWDWALFIGGFVPALIFGVAVGNVLQGVPFRLNGDLQIFYEGSFFGLLNPFALLCGILSVTMLTMHGAAWLVLKTDGVIQARARAYGSVAALLTVILYIVAGAISWLWVSGYRITSAVVMDGPSNPLQKTVELDHGAWFANYANYPILLIAPALGILGALAVLATLRGGRELAPLLFGKLSIFGIISSVGVSMFPFILPSSIDPQSSLTVWDSSSSHQTLFIMLVVTVVFIPIIVAYTAWVYKVLWGKVDKSMIEDESNHAY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cydB is a gene that is part of the cydAB operon encoding cytochrome bd oxidase , which catalyzes an alternate terminal electron transport step in bacterial respiration. Transposon (Tn5) mutagenesis of B abortus cydB was severely attenuated for intracellular survival. Unlike the virulent strain 2308, the Brucella cydB::Tn5 mutant was severely compromised for survival in the spleens of inoculated mice (Endley et al., 2001). The cydB and cydD mutants are also defective for the intracellular growth of B abortus and B suis, suggesting that functional cytochrome bd oxidase is required for growth in an intracellular environment (Endley et al., 2001).
COG COG1294C, under C: Energy production and conversion
References
Endley et al., 2001: Endley S, McMurray D, Ficht TA. Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection. Journal of bacteriology. 2001; 183(8); 2454-2462. [PubMed: 11274104].