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virB2 from Brucella melitensis biovar Abortus 2308

Victor ID 1760
Gene Name virB2 from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3827981
NCBI Protein GI 83269021
Locus Tag BAB2_0067
Protein Accession YP_418312.1
Other Database IDs UniProtKB-ID: VIRB2_BRUA2
UniRef100: UniRef100_Q2YIT6
UniRef90: UniRef90_Q2YIT6
UniRef50: UniRef50_Q2YIT6
UniParc: UPI0000058309
EMBL: AF226278
EMBL: AM040265
EMBL-CDS: AAF73895.1
EMBL-CDS: CAJ12233.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0067
HOGENOM: HBG683898
OMA: MAFAHAR
ProtClustDB: CLSK898648
BioCyc: BMEL359391:BAB2_0067-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 65610
Gene Ending Position 65927
Gene Strand (Orientation) -
Protein Name type IV secretion system protein VirB2 KO: K03197 type IV secretion system protein VirB2
DNA Sequence 
>gi|83268957:65610-65927 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
TTTACCTAAGCAGGTAAGAGGCAATTTCGGCGGCAGCGCCAACCACCAGGGCGCCGCCCAGCACCGGCAC
TACATCCATGAAGCGGGCGTGCCGGAATGCCATCTTGTAACCGGACCAGATGATGGCTATGGTAACGATG
GTGATCGATACGCCGCTTAGCAAGTCCAGCACTTTTTGCATGCTTGTATTTACCTTATCGAGGCCACCGT
TGGCGTGCGCCAGGTTAGGCTCGATTGCAGCGATGGAGACAATGAGGGCCAGCAGTAGGTGAGGTAGAAT
CCGCGACAGCGACTTCTTGCTGGGGGAAGCGGTTTTCA
Protein Sequence 
>gi|83269021|ref|YP_418312.1| type IV secretion system protein VirB2 [Brucella abortus 2308] MKTASPSKKSLSRILPHLLLALIVSIAAIEPNLAHANGGLDKVNTSMQKVLDLLSGVSITIVTIAIIWSGYKMAFRHARFMDVVPVLGGALVVGAAAEIASYLLR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The Brucella abortus virB operon, encoding a type IV secretion system (T4SS), is required for intracellular replication and persistent infection in the mouse model. The products of the first two genes of the virB operon, virB1 and virB2, are predicted to be localized at the bacterial surface. Both mutants were shown to be nonpolar, as demonstrated by their ability to express the downstream gene virB5 during stationary phase of growth in vitro. Both VirB1 and VirB2 were essential for intracellular replication in J774 macrophages. The nonpolar virB2 mutant was unable to cause persistent infection in the mouse model, demonstrating the essential role of VirB2 in the function of the T4SS apparatus during infection (den et al., 2004).

Polar mutations in the virB1 to virB2 intergenic region or in virB2 reduced the detection of VirB5 to a greater extent than they did that of VirB12. A virB1 mutation also eliminates the transcription of virB12 in B suis (Sun et al., 2005).
References
den et al., 2004: den Hartigh AB, Sun YH, Sondervan D, Heuvelmans N, Reinders MO, Ficht TA, Tsolis RM. Differential requirements for VirB1 and VirB2 during Brucella abortus infection. Infection and immunity. 2004; 72(9); 5143-5149. [PubMed: 15322008].
Sun et al., 2005: Sun YH, Rolán HG, den Hartigh AB, Sondervan D, Tsolis RM. Brucella abortus virB12 is expressed during infection but is not an essential component of the type IV secretion system. Infection and immunity. 2005; 73(9); 6048-6054. [PubMed: 16113325].