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narG from Brucella melitensis biovar Abortus 2308

Victor ID 1757
Gene Name narG from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3827924
NCBI Protein GI 83269759
Locus Tag BAB2_0904
Protein Accession YP_419050.1
Other Database IDs UniProtKB-ID: Q2YJY4_BRUA2
UniRef100: UniRef100_B2SBT9
UniRef90: UniRef90_A5VU29
UniRef50: UniRef50_P09152
UniParc: UPI00004F9404
EMBL: AM040265
EMBL-CDS: CAJ13070.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0904
eggNOG: COG5013
HOGENOM: HBG496975
OMA: REGPAQG
ProtClustDB: CLSK868288
BioCyc: BMEL359391:BAB2_0904-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 882843
Gene Ending Position 886577
Gene Strand (Orientation) +
Protein Name Nitrate reductase, alpha subunit:Prokaryotic molybdopterin oxidoreductase:Molybdopterin oxidoreductase:Molydopterin dinucleot...
DNA Sequence 
>gi|83268957:882843-886577 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
CATGAGTCTACTCCTCGACCGCCTGAACTTCCTGGCACGCAGGAATGTCGGCACCTTCTCGGAAGGGCAC
GGCGTCACCACCAATGAAAGCCGTGATTGGGAAGACGCCTATCGCAAACGCTGGCAGCACGACAAGATCG
TGCGCTCCACCCATGGCGTGAACTGCACCGGCTCCTGCTCGTGGAAGATCTATGTCAAGGGCGGCATCAT
CACCTGGGAAACCCAGCAGACCGACTATCCGCGCACCCGCGCGGATCTGCCGAACCACGAACCGCGCGGC
TGTCCGCGCGGGGCGAGCTATAGCTGGTACATCTACTCGGCCAACCGCGTGAAATATCCGCTGATCCGCT
CGCGCCTGCTGAAGCTGTGGCGCAAGGAACGCGCGGTGAAGACGCCGGTGGCCGCATGGGCTGCCATCCA
GCAGGACCCGGCCAAGCGTTCCGATTATATGAAGGTGCGCGGCCTCGGCGGCTTTGTGCGGGCGACATGG
GATGAGGTCAACGAGATCATCGCCGCCGCCAACACCTATACGACCAAGACCTATGGCCCTGACCGCGTGG
TTGGCTTCTCGCCGATCCCGGCCATGTCGATGGTTTCCTATGCGGCGGGCTCGCGTTATCTGTCGCTGCT
CGGCGGCGTCTGCATGTCCTTCTACGACTGGTATTGCGATCTTCCGCCTGCTTCGCCCATGACCTGGGGC
GAGCAGACAGACGTGCCGGAATCGGCAGACTGGTACAATGCCGGTTTCCTCATGCTGTGGGGCTCCAACG
TTCCGCAGACCCGCACGCCCGACGCGCATTTCTATACTGAAGCCCGCTACAAGGGCGCAAAGTCGGTCGT
CGTCTGCCCCGACTATTCGGAAGCCGCCAAGTTCTCCGATCTCTGGCTGCACCCGAAGCAGGGCACCGAT
GCCGCCCTTGCCATGGCTTTCGGCCATGTCATGCTGCGCGAATATCACCTCGACCGGCAGGTGCCCTATT
TCGAGGATTATTGCCGCAAATATTCCGACTTCCCGATGCTGGTCATGCTCACGAAGAAGGACGGCCACTA
CGTGCCGGGCCGTTTCGTGCGTGCATCCGACTTCGCCGACAATCTGGGCGAAGGCAACAATCCGGACTGG
AAAACGGTCGGCTTCGACACCAAGTCCGGCGCCTATGTCGCTCCGCAGGGTTCCATCGGCTTCCGCTGGG
GCGATGATGGCAAGTGGAACCTGGAAGAAAAGGACGGCAAGGGCAAGGATGTGGAACTTGCCAAGAGCTT
CATCGACAAGGACGCACATGATGCCGTTGCCGATGTGGCCTTCCCTTATTTCGGCAATCTCGACCATGAA
CATTTCGAGGGCACCGATCATGACAGCATCCTCGTGAGCAAGGTTCCCGCCCGCACGCTGAAGCTGAAGG
AAGGCGACGTGATGGTCGCCACTGTCTTCGATCTCTTTGCGGCCAATTACGGTCTCGACCGCGGCCTTGG
CGATGAAAACTGCGCCAAGAGCTATGATGACGGCCTGCCCTACACCCCGGCATGGGCCGAAAAGATCACC
GGCGTTCCGCGCGCCCAGATCATTGCGGTTGCCCGTGAATTTGCGACCAATGCCGAAAAGACCAATGGCC
GTTCCATGGTCATCGTTGGCGCCGGTCTCAATCACTGGTACCACATGGATATGAACTATCGCGGCATCAT
CAACATGCTGGTGATGTGCGGTTGCGTGGGGCAGTCCGGCGGCGGCTGGAGCCATTATGTCGGGCAGGAA
AAGCTGCGCCCGCAGACCGGCTGGACGGCGCTTGCCTTCGCGCTCGACTGGACCCGCCCGCCGCGCCATA
TGAACTCGACATCGTTCTTCTATGCGCACACCGACCAGTGGCGCTACGAGACCGTCAAGGTGCAGGATAT
CCTGTCGCCGACCGCGCCGGAAGGCAACTGGGACGGCACGATGATGGATTACAATATCCGCGCCGAGCGC
ATGGGCTGGCTCCCGTCCGCGCCGCAGCTTCAGGTAAACCCGCTGGAGGTCGCAAAACAGGCGGATGAAT
CCGGCAAGGACGCGAAGGATTTCGTTGCCGGCGCCCTGAAGAACGGCTCGATCACCATGTCCTGCGAGGA
TCCGGACCATGAGGCCAACTGGCCGCGCAACATGTTCGTCTGGCGTTCCAACCTGCTCGGTTCTTCCGGC
AAGGGCCATGAATATTTCCTGAAACATCTGCTTGGCACGTCGAACGGCCTGCTTGGCAAGGATCTCGGTC
AGGAAGGCGCACAGGAAAGCCGCGAGGCCGTGTGGCACGAACATGCGCCGGAAGGAAAGCTGGACCTTCT
GGTCACGCTCGACTTCCGCATGTCCACCACCTGCGTCTATTCCGATATCGTTCTGCCGACTGCAACCTGG
TACGAAAAGAACGATCTCAACACTTCCGACATGCATCCCTTCATCCATCCGCTGTCGAGTGCAGCCGATC
CGGCCTGGGAAGCGCGCAGCGACTGGGAAATCTTCAAGGGCATTGCCAAGAAGTTCTCCGATGTTGCACC
GGAAGTGCTGGGCGTAGAAAAGGACGTCGTTCTCGTGCCGACCCTGCACGATACGGCAGGCGAGCTGGCA
CAGCCCAAGGACGTTCTGGACTGGAAGCGCGGCGAAGTCGAACCGATCCCCGGCAAGACCATGCCATCGG
TCGTCGTCGTCGAACGCGACTATCCGAACCTCTACAAGCGCTACACCTCCGTTGGCCCGCTTCTCGACAA
GCTTGGCAATGGCGGCAAGGGCATTTCGTGGAACACCCAGCATGAGGTCGATCTGCTGGCCAAGCTCAAC
GGCAAGGTTGGCGAGCCGGGTACGAGCGAAGGCCGTCCGCGCATCGACACCGATATCGACGCCACGGAAG
TCATCCTGTCGCTGGCACCGGAAACCAACGGTGAAGTGGCCGTGAAGGCATGGGCTGCGCTGTCCAAGTT
CACGGGCCGCGACCACACCCATCTCGCCATTCCGAAGGAAGACGAGAAGATCCGTTACCGCGATATCGTC
GCACAGCCGCGCAAGATCATCTCCTCGCCCACCTGGTCGGGCCTGGAATCGGAAAGCGTGTGCTACAATG
CGGGCTACACCAACGTTCACGAACTGATCCCGTGGCGCACGCTGACCGGCCGTCAACAGCTCTATCAGGA
TCACCTGTGGATGCGCGCATTCGGCGAAGGCTTCTGCGTCTACCGCCCTCCGATCGATACGCGGACCGTC
AGCTCGGCCATTCGCGCCAAGACGGATGGACAGCCGCATCTGGTGCTGAACTTCATCACCCCGCACCAGA
AATGGGGCATCCACTCCACCTATTCGGACAACCTGTTGATGCTCACGCTCAATCGTGGCGGGCCGGTTGT
CTGGATAGCGGAACCGGATGCAGCCAGGGCCGGCATTGCCGATAATGACTGGGTGGAGATCTATAACTCC
AACGGCGCCATCGTGGCCCGTGCCGTGGTTTCGCAGCGCATGAGGGAGGGAACAACCTTCATGTACCACG
CACAGGAAAAGATCGTGAACACGCCGGGCTCGCCCCTGACCGGGCAACACGGTGGCATTCACAACTCCGT
CACCCGCGTCATCACCAAGCCTACGCACATGATTGGCGGTTATGCCCATCAGGCTTACGGCTTCAACTAT
TACGGGACCGTCGGCTCCAACCGCGACGAATTCGTGGTGGTGCGCAAGCTGGACAAGGTGGACTGGATGG
AAGGTCCGCTCGAAGAAGGCAACTA
Protein Sequence 
>gi|83269759|ref|YP_419050.1| nitrate reductase subunit alpha [Brucella abortus 2308] MSLLLDRLNFLARRNVGTFSEGHGVTTNESRDWEDAYRKRWQHDKIVRSTHGVNCTGSCSWKIYVKGGIITWETQQTDYPRTRADLPNHEPRGCPRGASYSWYIYSANRVKYPLIRSRLLKLWRKERAVKTPVAAWAAIQQDPAKRSDYMKVRGLGGFVRATWDEVNEIIAAANTYTTKTYGPDRVVGFSPIPAMSMVSYAAGSRYLSLLGGVCMSFYDWYCDLPPASPMTWGEQTDVPESADWYNAGFLMLWGSNVPQTRTPDAHFYTEARYKGAKSVVVCPDYSEAAKFSDLWLHPKQGTDAALAMAFGHVMLREYHLDRQVPYFEDYCRKYSDFPMLVMLTKKDGHYVPGRFVRASDFADNLGEGNNPDWKTVGFDTKSGAYVAPQGSIGFRWGDDGKWNLEEKDGKGKDVELAKSFIDKDAHDAVADVAFPYFGNLDHEHFEGTDHDSILVSKVPARTLKLKEGDVMVATVFDLFAANYGLDRGLGDENCAKSYDDGLPYTPAWAEKITGVPRAQIIAVAREFATNAEKTNGRSMVIVGAGLNHWYHMDMNYRGIINMLVMCGCVGQSGGGWSHYVGQEKLRPQTGWTALAFALDWTRPPRHMNSTSFFYAHTDQWRYETVKVQDILSPTAPEGNWDGTMMDYNIRAERMGWLPSAPQLQVNPLEVAKQADESGKDAKDFVAGALKNGSITMSCEDPDHEANWPRNMFVWRSNLLGSSGKGHEYFLKHLLGTSNGLLGKDLGQEGAQESREAVWHEHAPEGKLDLLVTLDFRMSTTCVYSDIVLPTATWYEKNDLNTSDMHPFIHPLSSAADPAWEARSDWEIFKGIAKKFSDVAPEVLGVEKDVVLVPTLHDTAGELAQPKDVLDWKRGEVEPIPGKTMPSVVVVERDYPNLYKRYTSVGPLLDKLGNGGKGISWNTQHEVDLLAKLNGKVGEPGTSEGRPRIDTDIDATEVILSLAPETNGEVAVKAWAALSKFTGRDHTHLAIPKEDEKIRYRDIVAQPRKIISSPTWSGLESESVCYNAGYTNVHELIPWRTLTGRQQLYQDHLWMRAFGEGFCVYRPPIDTRTVSSAIRAKTDGQPHLVLNFITPHQKWGIHSTYSDNLLMLTLNRGGPVVWIAEPDAARAGIADNDWVEIYNSNGAIVARAVVSQRMREGTTFMYHAQEKIVNTPGSPLTGQHGGIHNSVTRVITKPTHMIGGYAHQAYGFNYYGTVGSNRDEFVVVRKLDKVDWMEGPLEEGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The narG gene encodes for an essential component of the dissimilatory nitrate reductase complex. This complex is encoded by the narGHIJ locus, which is present in the B suis genome together with the gene of the nitrite extrusion protein, narK. The narG mutant was unable to produce nitrite from nitrate (Kohler et al., 2002). A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis xx gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG5013C, under C: Energy production and conversion
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].