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xseA from Brucella melitensis biovar Abortus 2308

Victor ID 1756
Gene Name xseA from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3827916
NCBI Protein GI 83269378
Locus Tag BAB2_0475
Protein Accession YP_418669.1
Other Database IDs UniProtKB-ID: EX7L_BRUA2
UniRef100: UniRef100_B2SAR1
UniRef90: UniRef90_B2SAR1
UniRef50: UniRef50_B6IXD4
UniParc: UPI00004F932E
EMBL: AM040265
EMBL-CDS: CAJ12641.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0475
eggNOG: COG1570
HOGENOM: HBG634411
OMA: LVWPVKV
ProtClustDB: PRK00286
BioCyc: BMEL359391:BAB2_0475-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 470639
Gene Ending Position 472174
Gene Strand (Orientation) +
Protein Name exodeoxyribonuclease VII large subunit
DNA Sequence 
>gi|83268957:470639-472174 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
CATGGCCTCCGATTCGAGTTTTCCCGGCGCATCGTCGAATGTGGCCGAGTATAGCGTGTCCGAGATTTCC
GGCGCTTTGAAGCGCACGGTTGAGGACACGTTCGGCCATGTGCGTGTGCGCGGCGAGATTTCCGGCTATC
GCGGCCCGCATTCTTCCGGCCATGCCTATTTTGCGCTGAAGGATGACCGTGCCCGGCTTGAAGCCGTGAT
CTGGCGCGGCTCGATGAGCCGCCTTCGCTTCCGCCCCGAAGAGGGCATGGAGGTGATCGCCACCGGCAAG
CTCACCACCTATCCCGGTTCATCCAAATATCAGATCGTCATCGAGCAGATGGAACCCGCCGGCGCGGGCG
CGCTGATGGCGCTTCTGGAGGAGCGCAAGCAGCGCCTGGCGGCAGAAGGCCTGTTCGATCCTACCCTGAA
ACAGCTTCTGCCCTTCATGCCGCGCGTCATCGGCGTGGTGACATCTCCCACCGGCGCGGTCATCCGCGAT
ATCATCCATCGCATTTCCGATCGTTATCCGCTGCGCGTGATCGTCTGGCCGGTGCGCGTGCAGGGCGATA
CCTGCGGGCCTGAAGTGGCAACGGCGGTGAACGGCTTCAACACCCTGCCGGATGACGGCCCCATTCCGCG
CCCCGATGTGCTGATCGTGGCGCGCGGCGGCGGCAGTCTGGAAGATCTCTGGGGCTTTAACGATGAAATC
GTCGTGCGGGCGGTCGCAGCTTCCCATATTCCTGTTATCTCGGCGGTCGGGCATGAAACCGACTGGACGC
TGATAGATCTTGCCGCCGACATGCGCGCGCCGACCCCCACCGGTGCTGCGGAAATGGCGGTGCCGGTGAA
GGCTGATCTTCAGGCCTCACTTGCCAGCCAGTCGGCGCGGCTTTCTTCCGCCATGTCGCGCTTTTTCGAC
CAGAAGCGACAGGCGCATCGTGCTGCCGCGCGCGCCATGCCCTCTGCCGACCAGTTGCTGGCCCTGCCGC
GCCGCCGGTTCGATGAAGCGGCCTCGCGGCTTACCCGCGCACTTTTCGTCAATACGCAGAAAAAGCGCGT
CCATTTCGATGGTCATGCCCGGCAATTGTCGCCCCGGCTTTTACAGCGGCGGCTTGTGGAGCTGGAACGC
GGTGTGACGATGCTGGGCCAGCGCCTGCCGCGCGCGCTGGAAGCCTTTCTGCGCGAGCGCCGGACGGCTT
TCACCCATCGCGCCAACCGGCTTTCGCCGGAACCCATATTGCGCCGCACACGGCTGACGGGCTCGACCCT
CGAACAGCTCGACCGCCGCCGCGATCAGGCCGTGCGGCTTCTGATCGAGCGTGTGAAGCGGCGCAGTCAA
GAACTCGACCGGTTGATGCGCACGCTTTCTTATGAAAGCGTGCTGGAACGCGGCTTTGCTGTTGTATTCG
ATGCGCAGGGCAAGCCCGTCAAGCAGGCGGCGGCTGTGTCGCCAGGCGATGCGCTGTCTGTCCGGTTCCG
CGACGGTGATGTCGGGGTTGTCGCGCGCGCGGGGCTCACAATCCCCGATCCGACCAAAGGCCAGTA
Protein Sequence 
>gi|83269378|ref|YP_418669.1| exodeoxyribonuclease VII large subunit [Brucella abortus 2308] MASDSSFPGASSNVAEYSVSEISGALKRTVEDTFGHVRVRGEISGYRGPHSSGHAYFALKDDRARLEAVIWRGSMSRLRFRPEEGMEVIATGKLTTYPGSSKYQIVIEQMEPAGAGALMALLEERKQRLAAEGLFDPTLKQLLPFMPRVIGVVTSPTGAVIRDIIHRISDRYPLRVIVWPVRVQGDTCGPEVATAVNGFNTLPDDGPIPRPDVLIVARGGGSLEDLWGFNDEIVVRAVAASHIPVISAVGHETDWTLIDLAADMRAPTPTGAAEMAVPVKADLQASLASQSARLSSAMSRFFDQKRQAHRAAARAMPSADQLLALPRRRFDEAASRLTRALFVNTQKKRVHFDGHARQLSPRLLQRRLVELERGVTMLGQRLPRALEAFLRERRTAFTHRANRLSPEPILRRTRLTGSTLEQLDRRRDQAVRLLIERVKRRSQELDRLMRTLSYESVLERGFAVVFDAQGKPVKQAAAVSPGDALSVRFRDGDVGVVARAGLTIPDPTKGQ
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)(UniProt: Q8FVR1).

CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates(UniProt: Q8FVR1).

SUBUNIT: Heterooligomer composed of large and small subunits (By similarity)(UniProt: Q8FVR1).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8FVR1).

SIMILARITY: Belongs to the xseA family(UniProt: Q8FVR1).

MUTATION: xseA codes for an exodeoxyribonuclease. B. melitensis xseA mutant via signature-tagged mutagenesis is attenuated in vivo in mice (Lestrate et al., 2003).
COG COG1570L, under L: Replication, recombination and repair
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].