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virB8 from Brucella melitensis biovar Abortus 2308

Victor ID 1755
Gene Name virB8 from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3827898
NCBI Protein GI 83269015
Locus Tag BAB2_0061
Protein Accession YP_418306.1
Other Database IDs UniProtKB-ID: VIRB8_BRUA2
UniRef100: UniRef100_Q2YJ78
UniRef90: UniRef90_Q2YJ78
UniRef50: UniRef50_Q2YJ78
UniParc: UPI000005830F
EMBL: AF226278
EMBL: AM040265
EMBL-CDS: AAF73901.1
EMBL-CDS: CAJ12227.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0061
eggNOG: COG3736
HOGENOM: HBG700868
OMA: LEMSDES
ProtClustDB: CLSK884263
BioCyc: BMEL359391:BAB2_0061-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 59744
Gene Ending Position 60463
Gene Strand (Orientation) -
Protein Name VirB8
DNA Sequence 
>gi|83268957:59744-60463 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
TTCATTGCACCACTCCCATTTCTGGATCAACGCGATAGCTCGTGACATTGAAACCCAGCGGGTTTGTCAG
GCGGGCCGATTCCGACATCAAAGAGGGATTGACGTATTGGTAGCCAATGGTGGCGATCCAGTGCGTTGTT
TCGCCGTCACCGGTCTCGTTGGTGCGCTTTGTCGTCTTCGCAAAGCGCACCGTGCCGATGCCCTTGCCGT
TCGGCACGATGCTTACGATCGTTACCGATGTGCGCACATTTGAGCCATATTGCTTGTCAAGCGCCTTATC
GCCCTGGAACTGGCTTGCATAGCTCTGCCCTTCGGACGGCGACGACAACATGCCTACGGTTTCGTAGTCC
TTTTGCAGCGTGTACCAGTCGTAGGTTTCACGCGCTATCACGTACTGCGAGAGCCAGTATTTATCCATTA
CAGTGTCGTAGCTGACACTCTTCTCGTCGAGCGAGGTCAGGATATCAGGCGCACCTGTCTGTGCGTTGAC
GCGCACCAGGTAGGGCACATGTTGCTTTAGCGGTAACATCCCGGCGATGCCGATCCCGAGCAGCACGGTA
ATGGTGCCGAAAGCCCCGGCGATTTTCCACGCGCGGCGTTCGGATTTTTCGACAAGCCGGACGTGCGCGG
CCTCCCAGTTCAACGCTTCGTCATATACCGAAGGCGCATTGCCCTGCCCGTTCTTTACTGATTTCTGTGG
AGATTGTTTGCGTCCAAACA
Protein Sequence 
>gi|83269015|ref|YP_418306.1| virulence protein [Brucella abortus 2308] MFGRKQSPQKSVKNGQGNAPSVYDEALNWEAAHVRLVEKSERRAWKIAGAFGTITVLLGIGIAGMLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKYWLSQYVIARETYDWYTLQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSVTIVSIVPNGKGIGTVRFAKTTKRTNETGDGETTHWIATIGYQYVNPSLMSESARLTNPLGFNVTSYRVDPEMGVVQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virB8 mutant was attenuated by a mini-Tn5 transposon mutagenesis (Foulongne et al., 2000). Attenuated non-polar virB2, virB4, virB8, virB9 and virB10 Brucella mutants are capable of penetrating cells as the same rate as the virulent wild-type Brucella, transit through EEA1-positive early compartments and then localize in LAMP1-positive compartments at early times of infection (Gorvel and Moreno, 2002).
COG COG3736U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].
Gorvel and Moreno, 2002: Gorvel JP, Moreno E. Brucella intracellular life: from invasion to intracellular replication. Veterinary microbiology. 2002; 90(1-4); 281-297. [PubMed: 12414149].