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pyrB from Brucella melitensis biovar Abortus 2308

Victor ID 1753
Gene Name pyrB from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3827823
NCBI Protein GI 83269525
Locus Tag BAB2_0641
Protein Accession YP_418816.1
Other Database IDs UniProtKB-ID: PYRB_BRUA2
UniRef100: UniRef100_B2SB57
UniRef90: UniRef90_B2SB57
UniRef50: UniRef50_A4VRI1
UniParc: UPI000005858D
EMBL: AM040265
EMBL-CDS: CAJ12807.1
RefSeq_NT: NC_007624.1
HSSP: P96108
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0641
eggNOG: COG0540
HOGENOM: HBG579429
OMA: MNRGLEI
ProtClustDB: PRK00856
BioCyc: BMEL359391:BAB2_0641-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 631340
Gene Ending Position 632308
Gene Strand (Orientation) -
Protein Name aspartate carbamoyltransferase catalytic subunit
DNA Sequence 
>gi|83268957:631340-632308 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
CTCATGCCGGTTCTCCGTTGCCTGGGTTGCGCCGCGGATCGAGCAGAGCCTCCATCACGGCCATGCGCAC
GGCAACGCCCATTTCCACCTGTTGCTGGATGACGCTTTGCGGCCCGTCCGCAACGTCGGAGGCAATCTCG
ACGCCCCGGTTCATCGGCCCCGGATGCATCACAAGTGCATCAGGTTTGGCGAATTTGAGTTTTTCCCGGT
CCAGGCCATAGAAATGGAAATATTCCCGCACGGAAGGCACGAAGGAACCCGCCATGCGCTCGCGCTGGAG
GCGCAGCATCATGACGACATCAGCGTCTTTCAGCCCCTCCTCCATGGAGTTGAAAACTTCCACGCTCATA
TCGGCCATGCCGGCGGGCAGGAGTGTTGAAGGCGCAACCACCCGCACCCGCGCGCCGAGCGCGTTGAGCA
GGAGAATGTTGGAGCGCGCCACGCGCGAATGCAGAACGTCACCGCAGATGGCGACGATCAGATTTTCGAT
CTGGCCCTTGGCGCGGCGGATTGTCAGCGCATCGAGAAGCGCCTGTGTGGGGTGTTCATGCGCGCCGTCG
CCCGCATTGACCACCGAGCAACCCACTTTCTGCGCGAGAAGGGCGGCAGCACCGGCGGAAGCATGGCGGA
TGACGAGAATATCCGGCTGCATAGCGTTCAGCGTCATCGCCGTATCGATGAGCGTTTCGCCTTTCTTGAC
CGATGAATTGCCGACGGACATATTCATCACATCCGCGCCCAGCCGTTTTCCGGCCAGCTCGAACGAAGAT
TGCGTCCGTGTCGATGCTTCAAAGAACAGGTTGATTTGCGTGCGACCGCGCAGCACGGACTTTTTCTTCT
CCGGCTGCCGGGAGACAGCGATTTCCTGATCGGCAAGATCGAGAAGGCAGAGAATGTCCAGGGGCGATAG
CCCCTTGATGCCAAGCAGGTGGCGGTGAGGGAAAAGCGGAGAGACCGTTTGATTTGTCA
Protein Sequence 
>gi|83269525|ref|YP_418816.1| aspartate carbamoyltransferase catalytic subunit [Brucella abortus 2308] MTNQTVSPLFPHRHLLGIKGLSPLDILCLLDLADQEIAVSRQPEKKKSVLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMQPDILVIRHASAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRAKGQIENLIVAICGDVLHSRVARSNILLLNALGARVRVVAPSTLLPAGMADMSVEVFNSMEEGLKDADVVMMLRLQRERMAGSFVPSVREYFHFYGLDREKLKFAKPDALVMHPGPMNRGVEIASDVADGPQSVIQQQVEMGVAVRMAVMEALLDPRRNPGNGEPA
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate(UniProt: P65612).

PATHWAY: Nucleotide biosynthesis; UMP biosynthesis; UMP from HCO(3)(-): step 2(UniProt: P65612).

PATHWAY: Context: Pyrimidine biosynthesis(UniProt: P65612).

SIMILARITY: Belongs to the ATCase/OTCase family(UniProt: P65612).

MUTATION: B. abortus pyrB (pyrimidines) gene is essential for intracellular growth in HeLa cells as shown from transposon mutagenesis study (Kim et al., 2003).
COG COG0540F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].