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ugpB from Brucella melitensis biovar Abortus 2308

Victor ID 1749
Gene Name ugpB from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3827694
NCBI Protein GI 83269478
Locus Tag BAB2_0585
Protein Accession YP_418769.1
Other Database IDs UniProtKB-ID: UGPB_BRUA2
UniRef100: UniRef100_Q2YKR5
UniRef90: UniRef90_Q2YKR5
UniRef50: UniRef50_Q2YKR5
UniParc: UPI00004F936F
EMBL: AM040265
EMBL-CDS: CAJ12751.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0585
eggNOG: COG1653
HOGENOM: HBG313575
OMA: ALWIAND
ProtClustDB: CLSK881850
BioCyc: BMEL359391:BAB2_0585-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 579285
Gene Ending Position 580586
Gene Strand (Orientation) -
Protein Name Bacterial extracellular solute-binding protein, family 1
DNA Sequence 
>gi|83268957:579285-580586 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
ATTATTGAGCTGCGGCGATTGCTGCGTTGCCGCGCTTGACGGCGTTGTCGAGTGCGGTCTTCGCGTCCTG
TTTGCCGCCCAGCATGGCTTCAAACTCTTCATTCAGAATGTCGCGAACCTGCGGCAGGTTGACGAGGCGC
ACACCCTTGGAATTTTCCGTCGGCTCCTTGCCCATCATTTGCAGGATCGGCGTTTCGCGGCCCGGATTCT
TTTCATAGAAATCCGACTTCTTGGTTTCCTCATAGGCTGCAAGCGTCACCGGCAGATAGCCGGATTTTTC
ATGCAGCTTGACCTGAATCTTGGTCTGCGAGAGGAAATTGAAGAATTCCGCGATGCCTTTGTACTGGTCG
TCGCTGAGGCCGGCGAATACCCAGAGCGAAGCGCCGCCCGGAATTGTGTTCTGCGGGCCATGGCCTTCAT
AATAAGGCAACTGGCCGATGCCGTAATTGATGCCCGACTTCACGACATCGCCCAGGCCGCCGGAGGATTC
CGTCAGCATGGCGCATTCGCCGGAGGTGAAGAGCTGCTTTGCCTCGGACGTGCGGCCGCCATAACGGAAC
GTGCCATCCTTGGCGAGATCGGCGATAGCCTGGAAGTGCTCGACATAAAGCGGCGAATTGATTTCGAGCT
TCACGTCGGTCCCGGCGAGGCCATTTTCATTCGTGCCATAGGGCACATTGTTCCAGGCGGCGAAGTTTTC
GGTCTGGATCCAGGTCAGCCAGGTGGAGGTGAAACCACAAGGCGATGCGCCGCTTGCCTTGATCTTTTTG
GCGGCTTCAAAAACTTCCGGCCAGGTCTTCGGCGGCTTGTTTTCATCAAGGCCGGCCTTCTTGAAGGCGT
CCTTGTTGTAATAGAGGATTGGCGAAGAGGAATTGTAGGGGAAGGACAACATGGTGCCGTCCGGCTTGGA
ATAATAAGCCACGATACCCGGCAGATATTGCGACTTGTCGAACTTGTAGCCACCCTTTTCGAGCACTTCG
GCAGCCGGAACTATGGCGCCTTCGGCTGCCATCATCACGCCGCTGCCAGCGTCGAAAACCTGAAGGATTG
CTGGCGGCTGCTTGGAACGGAATGCGGCGATGCCCGCGTTCAACGTTTCAGGATAGTTGCCCTTGTAAAC
CGGAACGATCTTGTATTCGCTCTGGCTTTCGTTGAACTCCTTGGAGAGCTCATTGACCATTTCGTTGTTG
GCGCCGGTCATGCCGTGCCACCATGCCAGTTCCGTCTGGGCAAAAGCCTGAGAACCGATGGTGAGCGCGA
TAGCTCCCGTGAGCACGGAAGTCGTGATCAGACGGGTGAACA
Protein Sequence 
>gi|83269478|ref|YP_418769.1| solute-binding family 1 protein [Brucella abortus 2308] MFTRLITTSVLTGAIALTIGSQAFAQTELAWWHGMTGANNEMVNELSKEFNESQSEYKIVPVYKGNYPETLNAGIAAFRSKQPPAILQVFDAGSGVMMAAEGAIVPAAEVLEKGGYKFDKSQYLPGIVAYYSKPDGTMLSFPYNSSSPILYYNKDAFKKAGLDENKPPKTWPEVFEAAKKIKASGASPCGFTSTWLTWIQTENFAAWNNVPYGTNENGLAGTDVKLEINSPLYVEHFQAIADLAKDGTFRYGGRTSEAKQLFTSGECAMLTESSGGLGDVVKSGINYGIGQLPYYEGHGPQNTIPGGASLWVFAGLSDDQYKGIAEFFNFLSQTKIQVKLHEKSGYLPVTLAAYEETKKSDFYEKNPGRETPILQMMGKEPTENSKGVRLVNLPQVRDILNEEFEAMLGGKQDAKTALDNAVKRGNAAIAAAQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B suis ugpB mutant does not contain SP41 protein. Mutants lacking SP41 production are less invasive, but proliferate in HeLa cells. An isogenic DeltaugpB mutant showed a significant inhibitory effect on Brucella adherence and invasion of human cultured epithelial cells and this effect could be reversed by restoration of the ugpB on a plasmid. (Castañeda-Roldán et al., 2006).
COG COG1653G, under G: Carbohydrate transport and metabolism
References
Castañeda-Roldán et al., 2006: Castañeda-Roldán EI, Ouahrani-Bettache S, Saldaña Z, Avelino F, Rendón MA, Dornand J, Girón JA. Characterization of SP41, a surface protein of Brucella associated with adherence and invasion of host epithelial cells. Cellular microbiology. 2006; 8(12); 1877-1887. [PubMed: 16817909].