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pyrD from Brucella melitensis biovar Abortus 2308

Victor ID 1740
Gene Name pyrD from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788883
NCBI Protein GI 82699235
Locus Tag BAB1_0341
Protein Accession YP_413809.1
Other Database IDs UniProtKB-ID: PYRD_BRUA2
UniRef100: UniRef100_B2S953
UniRef90: UniRef90_B2S953
UniRef50: UniRef50_A5EA61
UniParc: UPI00004F8EDD
EMBL: AM040264
EMBL-CDS: CAJ10297.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0341
eggNOG: COG0167
HOGENOM: HBG351027
OMA: AALNRMG
ProtClustDB: PRK05286
BioCyc: BMEL359391:BAB1_0341-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 341291
Gene Ending Position 342385
Gene Strand (Orientation) -
Protein Name dihydroorotate dehydrogenase 2
DNA Sequence 
>gi|82698932:341291-342385 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
TTTAAGATATAAGTTTGCGTGCGGCCCATTCCTTTGTGTCACGGTCGCGCAATTCAGCAATGCTGGAAAC
GCCTTCATGCTTGATTGCCGTGGAAAGGCCGCGCAGGATTTCACCCGGAAGGCCGGGGCCGCGATAGATC
AGCCCGGTATAAAGCTGCACCAGATCGGCGCCTGCCTTGATCTTGGCCAGCGCCGTTTCGGCACTGTCGA
TGCCGCCCACGCCGATCAGCGGCATATCGGGGCCGACGCGCTCGCGCATCCGCGCCAGAACCACGGTCGA
GCGTTCAAACAGCGGCGCACCGGAAAGCCCGCCGGTTTCATTGCTGTTTTCGGGATTTTTAAGCCCGCTT
CGCGATAGTGTCGTGTTGGAAACAATGATGCCGTCCAGCTTCTGCGCATCTGCTTCGGCGGCGATATCGT
CCAGTTCCTCATCGGTGAGATCAGGCGCAATCTTCAGGAAAACGGGCCGCTTCAGCGTGCACATATTTCC
CTCCTCGTCGCGCGCTTCCAGAACACGGCTCAAAAGCTCGTGCAGGGCCTCGCGCGCCTGGAGATTGCGC
AGCCCCGGCGTGTTGGGTGAGGAAATATTGACCGTGAAATAGCGCGCCAGCAGATAGAAGCGGCGGATAC
CGGCCACATAATCCGCGATCCGGTCTTCGGCATCCTTGTTCGCGCCGATGTTGACGCCGACAATGCCGCT
CTTGCCTGCGCGCCTGGAAAGACGCTTGAAGGCGGCTTCATGGCCCTCATTGTTGAAGCCGAGGCGGTTG
ATGACGGCCTTGTCGTCCACAAGTCGGAAAATGCGCGGGCGCGGATTGCCGCTTTGCGGGCGGGGGGTCA
GTGTGCCGACTTCCGCAAAGCCGAATCCAAGCTTCAGCAGCGCATCCGGCACTTCGGCATTCTTGTCGTA
ACCGGCAGCCATGCCGAGCGGATTGGGAAATTTCAGCCCCGCCACCTTCACCGAAAGGGCCGGATCTTCG
GGCGTGCGGCAAGTGACGATCCCGGTTTTCAGCCCGGTGATGGAAAGGCCGTGTGCCTGTTCCGCATCGA
AGGTGAAGAGGGCGCGCCGCCCCAGAGTTTCAAAAAGCCCACTCA
Protein Sequence 
>gi|82699235|ref|YP_413809.1| dihydroorotate dehydrogenase 2 [Brucella abortus 2308] MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYLLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGIIVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLIYRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B. suis pyrD mutation study indicated that pyrimidine synthesis pathway contributes to intracellular growth (Kim et al., 2003).
COG COG0167F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].