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pyc from Brucella melitensis biovar Abortus 2308

Victor ID 1739
Gene Name pyc from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788880
NCBI Protein GI 82700564
Locus Tag BAB1_1791
Protein Accession YP_415138.1
Other Database IDs UniProtKB-ID: Q2YLG1_BRUA2
UniRef100: UniRef100_B2S7K9
UniRef90: UniRef90_A6WXY5
UniRef50: UniRef50_A6UE85
UniParc: UPI00004F919B
EMBL: AM040264
EMBL-CDS: CAJ11747.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1791
eggNOG: COG1038
HOGENOM: HBG717218
OMA: DIVQSQI
ProtClustDB: PRK12999
BioCyc: BMEL359391:BAB1_1791-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1724070
Gene Ending Position 1727546
Gene Strand (Orientation) -
Protein Name pyruvate carboxylase
DNA Sequence 
>gi|82698932:1724070-1727546 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CTTACTCGGCGTAAACGATGAGCAAATCCTTCGCGTCGATCTGCTCGCCGGGGCGGACCAGCACTTCCGC
GATAGTGCCATCGCGTTCGGCATGGATGGCGGTTTCCATCTTCATCGCCTCGATGGATAGAAGCACGTCG
CCCTGCGTAACCTTCTGGCCTGCCACAACCGCAACGGTGGAGATAACGCCCGGCATTGGCGCACCGACCT
GTTTGTCATTGCCCGCCTCCACCTTGCGGCGGACACCACCGGAAGCACCCTTGGCACGGTTTGGCACCTT
GATGCGGCGCGGCTGGCCGTTCAGCTCGAAGAACACCGTCACCATGCCCTTCTCGTCGGTCTCGCTCATA
GCCTGATTGACGATCACCAGCGTCTTGCCACGCTCCAGATCGACAAAAACTTCTTCTTCCGGCTTGAGGC
CGTAGAAATAAACCGGCGTCGGCAGCACGCTCGTCGGACCATAGGTTTCATGCGCCGTAGCATAATCGGT
GAAGACCTTCGGATACATCAGCGCCGAAGCAAATTCCTGATCGGAAAGCTTGCGGCCGACACTGTCCTCA
AAGCTCTTGCGTTCCGCATCGAGATCGGCGGCAGGCAGAAGCGAGCCGGGGCGCACGGTGAAAGGCTTTT
CACCTTTCAGAACCTTTTTCTGCAAGGCTTCCGGCCAGCCGGATGGCGGCTGGCCGAGATCGCCACGCAT
CATGGAAACCACCGAATCCGGGAAGGCAATATCCTTGGCAGGGTTCTCGACATCGGCAACAGTGAGGTCT
TGGGCAACCATCATCAGCGCCATGTCGCCCACCACCTTGGAGGATGGCGTGACCTTGACGATATCGCCGA
ACATGCGGTTCACATCGGCATAGGCCTGCGCCACTTCATGCCAGCGCGTTTCAAGCCCCAGCGAGCGCGC
CTGTTCCTTCAGATTGGTGAACTGGCCACCCGGCATTTCGTGAAGATAGACTTCCGAAGCCGGTCCCTTG
AGGTCGCTTTCAAAAGCTGCATATTGATGGCGCACCGCTTCCCAATAAAAGGAAATACGGCGGATCGAAT
CCGGGTCGAGCCCCGAATCACGCTCGGAACCATGCAGCGCTTCAACGATGGAACCGAGGCAGGGCTGCGA
TGTATTGCCCGAAAGTGCGTCCATCGCTGCATCCACGACATCCACGCCCGCATCGATTGCAGCAAGCACG
GTCGCCGCCGAAATGCCCGACGTATCATGTGTGTGGAAATGGATCGGCAGATCGGTTTCCTCGCGCAGCG
CCTTGAACAGCACGCGCGCGGCGGCAGGCTTCAGCAAGCCCGCCATATCCTTGACCGCAATAATATGCGC
GCCAGCCTTTTCCACTTCCTTCGCCAGATTGACGTAATAATTAAGGTCGTATTTGGCGCGATCCGGGTTC
AAAATATCGCCCGTATAGCAGATCGCCGCTTCACAGAGCTTGTTTTCCTCCAGCACCGCATCCATCGACA
CGCGCATGTTCTCAACCCAGTTGAGGCTGTCGAAAACGCGGAACAGGTCAATGCCCGCGCGCGCTGCCTC
GCGCACGAAATATTTCACCACATTGTCCGGATAGGATTTGTAGCCAACCCCGTTCGCACCGCGCAGAAGC
ATCTGCAACAGGAGGTTGGGCGCGCCTTCGCGCACCAGTGCCAGACGCTCCCACGGGTCTTCGGTCAGGA
AGCGCATGGAGACGTCGAAAGTAGCCCCGCCCCAGCATTCCAGCGAGAATAGGTTTGGCAGCGCCTGCGC
GTAAGCATTGGCGATCCGCGCAATATCATAGGTGCGCACGCGCGTGGCAAGCAATGACTGGTGGCCATCG
CGCATGGTGGTATCAGTAATCAGCGCGCGCTTTTCATTGCGCATCCATTCGGCAAACTTCTTCGGCCCAA
GCTGGCCCAGAAGCTGTTTGGTGCCGTCAGCGACCAGCTTGTCGCCAAACCACGGCACGCGCGGCTTGGC
AGCATCCCTGGCGGGTTTCGCGCGGCCCTTGGTTTCGGGATGGCCGTTGACGGTCACATCGGCAATATAG
GTCAAAAGCTTGGTGGCGCGATCCTGCCGCTTCATCTGCTCGAACAATTCCGGCGTCGTATCGATGAAAC
GGGTCGTATAATCGTTCGACTGGAATTTCGGATGATTGATGATCGCTTCGAGGAAGGTGAGGTTCGTTGC
CACGCCGCGAATGCGGAACTCGCGCAAGGCGCGGTCCATGCGGTGAATGGCTTCAAGCGGCGTCGCGCCG
GATGCCGTCACCTTTACCAGAAGCGGGTCGTAATAACGGGTGATGAATGCGCCCGAATAGGCCGTGCCGC
CATCGAGACGGATGCCGAAGCCCGCCGCCGAACGATAGGCCTGAATGCGCCCGTAATCGGGGATGAAATT
CTGTTCCGGGTCTTCCGTTGTGATGCGGCATTGCAGCGCGTGGCCATTGAGGCGGATATCCTCCTGGCGC
GGCACGCCCGATTCCGGCGTGCCGATGGCAAAGCCTTCCAGAATATGGATCTGCGCCTTGACGATATCGA
TGCCGGTCACTTCTTCCGTGACCGTATGCTCCACCTGAATGCGTGGATTGACCTCGATGAAATAGAACTT
GCCGGTATCGGCATCCATGAGGAACTCAACCGTGCCAGCACCGATATAATCGGTGGCATGCGCGATCTTC
AGGCCATAATCGGCCAGCTCGCGGCGCTGCGCATCGTTGAGATAGGGTGCAGGCGCGCGCTCCACGACCT
TCTGGTTACGGCGCTGGATGGAGCAGTCACGCTCAAAAAGATGGACCGCATTGCCGTACGTATCGCCCAA
TATCTGCACTTCGACATGGCGGGCACGCTCCACCAGCTTTTCGAGATAAACTTCATCCTTGCCAAAGGCC
GCCTTGGCCTCGCGCTTGGCTTCCATCACCTCGCGGGCAAGATCGGCTTCAGCCCGGATGGCGCGCATAC
CGCGGCCGCCGCCGCCCCAGCTTGCTTTCAGCATCAGCGGATAGCCGATCTGGGCGGCAAGCTTCTTCAC
CTCATCCATATCATCCGGCAGCGGATCGGTGGCAGGCACCACCGGCACGCCAATCTCGATAGCGAGATTG
CGCGCGGCGACCTTGTTGCCGAGGCGGCGCATGGTTTCCGGCTTCGGCCCGATGAAGACGATACCGTTTT
CCGCGCAGGCTTCGGCAAATTCCGGGCTTTCCGACAGGAGACCGTAACCTGGATGGATCGCATCGGCGCC
CGAAAGCTTGGCAACGCGGATGATTTCGTCAATGGAAAGATAGCTTTCAATGGGGCCAAGATCGCGATCC
AGATGCGGTCCGCGACCGACCTGATAGCTTTCATCCGCCTTGAAGCGATGCAGGGAAAGCTTGTCTTCCT
CAGCCCATATGGTCACCGTTTTGAGCCCCAGCTCATTGGCGGCGCGGAATACGCGAATTGCGATTTCAGA
TCGGTTGGCGACCAGAATTTTCGAGATAGGCTTTGGAGCGAAAGACA
Protein Sequence 
>gi|82700564|ref|YP_415138.1| pyruvate carboxylase [Brucella abortus 2308] MSFAPKPISKILVANRSEIAIRVFRAANELGLKTVTIWAEEDKLSLHRFKADESYQVGRGPHLDRDLGPIESYLSIDEIIRVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKPETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKLAAQIGYPLMLKASWGGGGRGMRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFERDCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYFIEVNPRIQVEHTVTEEVTGIDIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRITTEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFITRYYDPLLVKVTASGATPLEAIHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATKLLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLGQLGPKKFAEWMRNEKRALITDTTMRDGHQSLLATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRFLTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNVVKYFVREAARAGIDLFRVFDSLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHIIAVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMDALSGNTSQPCLGSIVEALHGSERDSGLDPDSIRRISFYWEAVRHQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMFGDIVKVTPSSKVVGDMALMMVAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSLLPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYGLKPEEEVFVDLERGKTLVIVNQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKGASGGVRRKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIEAMKMETAIHAERDGTIAEVLVRPGEQIDAKDLLIVYAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyc is one B. suis gene identified by signature-tagged mutagenesis. It is essential for survival and mulitplication in macrophages (Foulongne et al., 2000).
COG COG1038C, under C: Energy production and conversion
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].