Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

purM from Brucella melitensis biovar Abortus 2308

Victor ID 1737
Gene Name purM from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788878
NCBI Protein GI 82699599
Locus Tag BAB1_0731
Protein Accession YP_414173.1
Other Database IDs UniProtKB-ID: PUR5_BRUA2
UniRef100: UniRef100_B2S4W8
UniRef90: UniRef90_A6X235
UniRef50: UniRef50_A6X235
UniParc: UPI00000DD393
EMBL: AM040264
EMBL-CDS: CAJ10687.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0731
eggNOG: COG0150
HOGENOM: HBG531222
OMA: HYDLAGF
ProtClustDB: PRK05385
BioCyc: BMEL359391:BAB1_0731-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 714583
Gene Ending Position 715662
Gene Strand (Orientation) -
Protein Name phosphoribosylaminoimidazole synthetase
DNA Sequence 
>gi|82698932:714583-715662 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
TTCATAGTGCGAGCTGGCCCTTGTAGATGACGCCGTCTTTCTCACGCCGGGTCATGCGGCCGAGTGTAAC
GACCTTTTCGCCTTCGGCTGCAAGTGCTGCGATCACTTCATCGACCTTTGCCGGATTGACGACCGCAATC
ATGCCGATGCCGCAATTGAAGGTGCGCAGCATTTCATTCGGTTCGACATTGCCAGTCTTGGCAAGCCAGG
AGAAAACCGGCGGGACTGCAATGGCCGGAAGATCAATCTCCGCAGCCAGGCCTTTCGGCAGGACGCGGGG
AATATTGTCGGGGAAGCCGCCGCCTGTAATATGCGCCAGCGCCTTGATGCCGTCGCAGGCACGGATGGCG
GCGAGCAGCGGCTTGACGTAAATCCGCGTCGGGGTGAGCAGGGCTTCACCGAGCGTTGCGCCCGGTTGGA
AAGGGGCCTGCGACTTCCAGCCGAGGCCGGAAAGCTCGACGATGCGGCGCACAAGCGAGAAGCCGTTGGA
ATGAACGCCCGAGGAAGCAAGGCCCAGAATGATGTCGCCTTCGGCAATATCGCCGCGCGGCAGCAGGCGG
TCACGTTCTGCTGCGCCCACGGCAAAACCTGCAAGATCGTAATCGCCGTCGCGATACATGCCCGGCATTT
CCGCCGTCTCACCGCCGATCAGTGCGCAGCCCGCCTGACGGCAGCCTTCCGCGATGCCCGAAACGATCGC
GACGCCCTGATCCGGCGAAAGCTTGCCGGTGGCGTAATAATCGAGAAAGAAAAGCGGTTCCGCGCCCTGC
ACGACCAGATCGTTCACGCACATCGCCACGAGATCGATGCCGACAGTATCATGGATATCCGCATCAATAG
CGATCTTGAGCTTGGTGCCGACACCATCATTGGCCGCAACCAGAACCGGATCCTTGAAGCCCGCAGCCTT
GAGATCGAACAAACCGCCGAACCCGCCGATTTCGCCATCCGCACCGGGGCGGCGTGTCGAGCGCACCAAT
GGCTTGATCTTTTCGACCATCAGGTTGCCGGCATCGATATCAACACCAGCCTGCGCATAGGTCAGGCCGT
TTTGGCCGGCGGGCTTGTTTTCCATGGTCA
Protein Sequence 
>gi|82699599|ref|YP_414173.1| phosphoribosylaminoimidazole synthetase [Brucella abortus 2308] MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKDPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVKPLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole(UniProt: Q8G1K5).

PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2(UniProt: Q8G1K5).

PATHWAY: Context: Purine biosynthesis(UniProt: Q8G1K5).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G1K5).

SIMILARITY: Belongs to the AIR synthase family(UniProt: Q8G1K5).

MUTATION: B. abortus purM gene is essential for intracellular growth in HeLa cells as shown from transposon mutagenesis study (Kim et al., 2003).
COG COG0150F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].