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pth from Brucella melitensis biovar Abortus 2308

Victor ID 1733
Gene Name pth from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788869
NCBI Protein GI 82700344
Locus Tag BAB1_1552
Protein Accession YP_414918.1
Other Database IDs UniProtKB-ID: PTH_BRUA2
UniRef100: UniRef100_Q2YLX5
UniRef90: UniRef90_Q2YLX5
UniRef50: UniRef50_Q2YLX5
UniParc: UPI00000BAEB8
EMBL: AM040264
EMBL-CDS: CAJ11508.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1552
eggNOG: COG0193
HOGENOM: HBG610927
OMA: AMHRLHS
ProtClustDB: PRK05426
BioCyc: BMEL359391:BAB1_1552-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1501400
Gene Ending Position 1502152
Gene Strand (Orientation) +
Protein Name peptidyl-tRNA hydrolase
DNA Sequence 
>gi|82698932:1501400-1502152 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CATGCTGCTCATCGCAGGTCTTGGCAATCCGGGTCCCCAATATGCGCATAACCGGCACAATATCGGTTTC
ATGGCGGCGGATGAAATATTCCGCCGCCATCGCTTTTCCAACTGGCAGAAGAAATTTCAGGCAGAGATCG
CCGATGGCGTGATCGACGGCGAGAAAGTGTTGCTGGTCAAACCGCAGACTTTCATGAACCTTTCCGGCCA
GTCTATCGGCGAGGCCATGCGCTTCTACAAGATGACGCCTGCCGATCTCGTCGTGATCTATGATGAACTG
GACCTCGTTCCGGGCAAGCTGCGCATCAAGACCGGCGGCGGTTCCGGCGGCCATAACGGCATCAAATCCA
TCGACGCACATATGCAGTCCTTCCCCGGCGGACAGAATTATCGCCGCATGCGGCTTGGCATCGGCCATCC
CGGCGCGAAGGAACTCGTGCATAATTATGTTCTGGGCGATTTCGCCAAGGCCGACAATGAATGGCTGGAT
ACGCTTATGGGCGCCGTCGCCGACAATGTCGCCATGCTTGCCAGACGCGAGGATAACAGCTTCATGAACC
GCATTGCACTCGCCATGGGCGACGGCAATCAGCGGCCAGGCGGCGTCAAGACAGATCCCGCGCAATTGGA
GAAGGCTCCGCCAAAGGCCCAGAGCCATATTCGTCAGGCGCGCCAGAACCAGAAAAAGCCCAATATTCCC
GAAAGCGGCCCGATGGCTGAAATGCTGAAAAAGCTGCTGGGGAAGAAGGATTA
Protein Sequence 
>gi|82700344|ref|YP_414918.1| peptidyl-tRNA hydrolase [Brucella abortus 2308] MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYKMTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAEMLKKLLGKKD
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity)(UniProt: P65864).

CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA(UniProt: P65864).

SUBUNIT: Monomer (By similarity)(UniProt: P65864).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: P65864).

SIMILARITY: Belongs to the PTH family(UniProt: P65864).

MUTATION: pth encodes for a peptidyl tRNA hydrolase. Transposon insertion in pth has a polar effect on dugA expression and that the pth/dugA mutant is deficient in iron assimilation because of altered expression of the dugA gene. Only minor difference in intracellular growth in bovine macrophages and HeLa cells between the pth/dugA mutant and wild-type strains was observed (Danese et al., 2004).
COG COG0193J, under J: Translation, ribosomal structure and biogenesis
References
Danese et al., 2004: Danese I, Haine V, Delrue RM, Tibor A, Lestrate P, Stevaux O, Mertens P, Paquet JY, Godfroid J, De Bolle X, Letesson JJ. The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M. Infection and immunity. 2004; 72(10); 5783-5790. [PubMed: 15385478].