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pheA from Brucella melitensis biovar Abortus 2308

Victor ID 1732
Gene Name pheA from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788850
NCBI Protein GI 82698963
Locus Tag BAB1_0034
Protein Accession YP_413537.1
Other Database IDs UniProtKB-ID: Q2YPM5_BRUA2
UniRef100: UniRef100_D0B4A3
UniRef90: UniRef90_D0B4A3
UniRef50: UniRef50_B6JJE5
UniParc: UPI00000DD192
EMBL: AM040264
EMBL-CDS: CAJ09990.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0034
eggNOG: COG0077
HOGENOM: HBG693866
OMA: EDEAHNT
ProtClustDB: PRK11899
BioCyc: BMEL359391:BAB1_0034-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 38472
Gene Ending Position 39335
Gene Strand (Orientation) -
Protein Name prephenate dehydratase
DNA Sequence 
>gi|82698932:38472-39335 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
ATTATTCGGCAGCCAGTAGCTGCGTACCGCGAATATCGCTTCCCTTGTAAACGCCCAGAATTCGCACTTC
CTTGGTGAAGAAGCGCAGTTCTTCCAGTGCAAGCTGCACCGAACGCTCTTCCGGGTGTCCCTCGATATCG
GCATAGAACTGCGTTGCGATGAAGCGTCCGCCGAGCTGATAGCTTTCGAGCTTCGTCATATTGACGCCAT
TGGTGGCGAAACCGCCCAGCGCCTTGTAAAGTGCGGCGGGCACGTTGCGCACCCGGAACACGAAGGTCGT
CACAATGCGCTCGTCGTTTTCAGGCCGCGCCGCCCACTGCTTGTTCTTGGAGAGGACCACGAAGCGGGTG
ACGTTGTTTTCGGAATCCTCGACATTTTCTTCCAGAATATCGAGGCCGTAGAGATCGGCGGCAAGACGTG
GCGCGAGGGCCGCCATCGAGCGATCCTTCACATCGGCGACGAGGCGCGCGGCCCCTGCCGTGTCACCGGC
AATCACACCCTTCCAGCCGTTCTGGCGGATGACGTTGCGGCACTGGCCGAGCGCGTGGATATGGCTGTGC
ACCGTCTTGATTTCCTCGCGCCGGACACCCGGAAGCACCATAAGCTGGAAATGGATCGGCAGGAAATATT
CGCCAACAATGTGCATGTCGGCCAGCGGCAGCAGATAATGAATATCGGCGACGCGCCCGGCCAGCGTGTT
CTCGATCGGGATCATCGCGAGGTCTGCGGCGCCGGTTTCAACCGCATTGAAGGCATCCTCAAAAGTCGGG
CACGGCAAAGGCTCCATATCGGGAAACATGTTGCGGCACGCCGTATCGGAGTTTGCGCCTGCTTCACCCT
GGAAGGAAATCCTGTTGGTTTTCA
Protein Sequence 
>gi|82698963|ref|YP_413537.1| prephenate dehydratase [Brucella abortus 2308] MKTNRISFQGEAGANSDTACRNMFPDMEPLPCPTFEDAFNAVETGAADLAMIPIENTLAGRVADIHYLLPLADMHIVGEYFLPIHFQLMVLPGVRREEIKTVHSHIHALGQCRNVIRQNGWKGVIAGDTAGAARLVADVKDRSMAALAPRLAADLYGLDILEENVEDSENNVTRFVVLSKNKQWAARPENDERIVTTFVFRVRNVPAALYKALGGFATNGVNMTKLESYQLGGRFIATQFYADIEGHPEERSVQLALEELRFFTKEVRILGVYKGSDIRGTQLLAAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The product of pheA gene is specifically dedicated to the biosynthesis of phenylalanine. The B. abortus pheA mutant with mini-Tn5 disruption displays nutritional defects in vitro. Experimental findings with the B abortus ilvD, trpB, and pheA mutants suggest that tryptophan and phenylalanine are available to the brucellae in their intracellular niche but that other amino acids (eg, leucine, isoleucine, or valine) are not. The pheA::miniTn5 mutant displayed attenuation in macrophages but not in mice (Alcantara et al., 2004).
COG COG0077E, under E: Amino acid transport and metabolism
References
Alcantara et al., 2004: Alcantara RB, Read RD, Valderas MW, Brown TD, Roop RM 2nd. Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model. Infection and immunity. 2004; 72(8); 4911-4917. [PubMed: 15271960].