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pepN from Brucella melitensis biovar Abortus 2308

Victor ID 1730
Gene Name pepN from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788843
NCBI Protein GI 82699509
Locus Tag BAB1_0641
Protein Accession YP_414083.1
Other Database IDs UniProtKB-ID: Q2YMX0_BRUA2
UniRef100: UniRef100_B2SAA2
UniRef90: UniRef90_B2SAA2
UniRef50: UniRef50_B8IP01
UniParc: UPI00004F8F6E
EMBL: AM040264
EMBL-CDS: CAJ10597.1
RefSeq_NT: NC_007618.1
MEROPS: M01.005
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0641
eggNOG: COG0308
HOGENOM: HBG289207
OMA: EYFHNWS
ProtClustDB: PRK14015
BioCyc: BMEL359391:BAB1_0641-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 629801
Gene Ending Position 632452
Gene Strand (Orientation) -
Protein Name Membrane alanine aminopeptidase:Neutral zinc metallopeptidase, zinc-binding region
DNA Sequence 
>gi|82698932:629801-632452 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
ATCAGGCGAGCGTTCGGTCGATGATGTCGCGCAGATCGGTGGAGAGTTTGCCTGCGCCTGCAATGCGCGC
CAGTGCCGCGCGGGCATGTTCGCGCCGCACCTCTTCCAGCGACCGCCATGAGCGCATTGCCGTCAAAAGC
CGTGCGGAAAGCTGCGGGTTTTTCGGATCAATGGTCAGAAGCGTATCGGCGAGGAAACCATAGGCTGCAC
CATCTTGGCGGTTGAACCCGGTCGGGTTGGAAGCCGTAAATGCGCCGATGAGCGCGCGCACGCGATTTGG
ATTGTCGAGAGAAAAGAGCGGATGGCGGGTCAGTTCCCTCACTGCTTCAAGGGCCGTTTCGCCGGGGCGT
GTCGCCTGCACGATGAACCATTTGTCCATCACGAGCGCATCCTGGCCGAACGTTTGCTCGAAGGTTGCGA
GCGCCTGACGGGCTTCGCCGCTATCGCCAAAACGATGGACCAGAACGGCCAGCGCCGTGGCGCGGTCCGT
CATGTTGTCGGCTTCGACAAATTGCCTTTCTGCACGTTCAGGGCTCTTTTCCTGAACGCTGAGATAATCG
AGAAGGGCGCTACGCAAGGCACGCTTTCCCGCCGGGGCCGCATCGGGTGAAAACGCCCCTTCCTGCTTCA
GCGTGTCATAGAGCCCGGCAAATCCATCGGCATAGGCTGAAGCGATTGCTGCAATCAGATGGTTGCGGCT
GGCGAGGATTGCGTCTGGATCGACATTGTTACCCATTTCGCGCGCGATATCGCTTTCGCTCGGCAGCGTC
AGGCAAAGCGCCCGGAAAGCCGGGTCCAGCATTTCATCGAAGGCGACCTTTCCGGCCAGCGCGACGATCT
TCGGATCGGTTTCCGGCTGATGCCCGCCGCGCACACGCTTGGCGCCATCCAGAAGGGTCGCAGAGAAAAT
GCTGTTCATCGCCTGCCAGCGCGCAACGGGGTCGCTATCGTTCAGGGCAAGGAAAACCCGGTCTTCCGCC
GTGAGAGGCGCGGCGAGATTGACTGGCGCCGAAAAGCCGCGCAGCAGCGACGGCACGGGCCGGGCCTCGA
TGCCATGGAAGACGATGGTTTCGGATGGGCGGCGCAAATGGATTACGCCGTCGCGCACCTCGCCGCCTTC
CACCGACGAGGGCTGCATGTCTTTGCCGTCCGGCCCGATCAGGCCGAAGGCAATGGGTATATGCATGGGC
TTCCTGATCGACTGGCCGGGTGTCGGCGCAAGTGACTGTTCCAGCTTGATCGTGAATGTCTTCGCGGCTG
CGTCATGATGGAACCCGGCTTCCACCTTCGGTGCACCGGCCTGATCGTACCAGAGCGCGAATTGCGAGAA
ATCCTGCCCGGAAACATCGGCAAAAACCTGGATGAAATTCTCGATGGTCGCCGCATCGCCGTCATGGCGC
TCGAAATAGAGGTCCATGCCCTTGCGGAACAGCTCCGGCCCGATGATGGTGCGGATCATGCGAACGACTT
CCGAACCTTTTTCATAGACGGTTGCCGTATAGAAATTATTGATCTCGCGATATTCGCGAGGGCGCACCGG
ATGGGCAAGCGGGCCTGCATCCTCCGGGAATTGCTGCGCTTTCAGGATTTTCACCTCCGCAATGCGCTTG
ACAGGGCGCGAGCGCTGGTCGGCGGAAAATTCGTGATCGCGATAAACCGTCAGGCCTTCCTTGAGGCATA
GCTGGAACCAGTCGCGGCAGGTGATGCGGTTGCCGGTCCAGTTGTGGAAATATTCATGCGCGATAACGGC
TTCGATGCCGGCATAATCCGCATCGGTCGCGGTTTCAGGATCGGCCAGCACATATTTGTCGTTGAAGATA
TTGAGGCCCTTGTTCTCCATCGCGCCCATGTTGAAATCGGAGACGGCGACGATATTGAAAACGTTAAGGT
CATATTCGCGGCCGAATTTTTCCTCGTCCCATTTCATGGAGCGTTTCAGCGCGTCCATCGCATAAAGCGC
GCGGCCCTCCTTGCCATGTTCCACATGGATGGCGAGATCGACGGGCCGTCCAGATCGGGTTGTAAAGTGG
TCTTTCACCACGCCGAGCGAACCGGCGACGAGCGCGAAAAGATAGGAGGGTTTTGGATGCGGGTCGTGCC
AGACGGCAAAATGCCGTTCCGGCTGGCCCTCCACCATGCCGTTTTCGACAGGGTTGCCGTTTGAAAGCAG
GATGGGAGCGGCTTTCCGGTCGGCATCGACACGCACCGTATAGACCGACAGCACGTCCGGGCGGTCGTAA
AAATAGGTGATGCGACGAAAGCCTTCCGCCTCGCATTGGGTGCAATAGACGCCGCTGGAGCGGTAAAGGC
CGGAAAGCTGGCGATTGGCTGTTGGGTTCACCTCGGTCACGATCTGCAAGGTGAAGCGCACATCTTTCGG
AAGATCGCTGATGGTCAACTGGTCGGGCGTGGCCGAAAAGCTGTTGTCGGAAAGCGCCTTGCCGTCGATG
GCAAGGCTCACGAGCTTCAATTCGTCACCGTGGAGAACGAGCGGCGTACCGGCGGGCGTATCGGAGCGGC
GCTCTATGGTGAGCGTTGCGCGCACGATGGTTTTTTCCGGCTCCAGTGTGAAGTCGAGTTTCGTTTCGGG
TATGGCGTAAGGTGTCTGGCGATAATCTTCGAGACGGAAAGTATGGCCGGTTTCAGTACGCA
Protein Sequence 
>gi|82699509|ref|YP_414083.1| aminopeptidase N [Brucella abortus 2308] MRTETGHTFRLEDYRQTPYAIPETKLDFTLEPEKTIVRATLTIERRSDTPAGTPLVLHGDELKLVSLAIDGKALSDNSFSATPDQLTISDLPKDVRFTLQIVTEVNPTANRQLSGLYRSSGVYCTQCEAEGFRRITYFYDRPDVLSVYTVRVDADRKAAPILLSNGNPVENGMVEGQPERHFAVWHDPHPKPSYLFALVAGSLGVVKDHFTTRSGRPVDLAIHVEHGKEGRALYAMDALKRSMKWDEEKFGREYDLNVFNIVAVSDFNMGAMENKGLNIFNDKYVLADPETATDADYAGIEAVIAHEYFHNWTGNRITCRDWFQLCLKEGLTVYRDHEFSADQRSRPVKRIAEVKILKAQQFPEDAGPLAHPVRPREYREINNFYTATVYEKGSEVVRMIRTIIGPELFRKGMDLYFERHDGDAATIENFIQVFADVSGQDFSQFALWYDQAGAPKVEAGFHHDAAAKTFTIKLEQSLAPTPGQSIRKPMHIPIAFGLIGPDGKDMQPSSVEGGEVRDGVIHLRRPSETIVFHGIEARPVPSLLRGFSAPVNLAAPLTAEDRVFLALNDSDPVARWQAMNSIFSATLLDGAKRVRGGHQPETDPKIVALAGKVAFDEMLDPAFRALCLTLPSESDIAREMGNNVDPDAILASRNHLIAAIASAYADGFAGLYDTLKQEGAFSPDAAPAGKRALRSALLDYLSVQEKSPERAERQFVEADNMTDRATALAVLVHRFGDSGEARQALATFEQTFGQDALVMDKWFIVQATRPGETALEAVRELTRHPLFSLDNPNRVRALIGAFTASNPTGFNRQDGAAYGFLADTLLTIDPKNPQLSARLLTAMRSWRSLEEVRREHARAALARIAGAGKLSTDLRDIIDRTLA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A single mutation of PepN leads to a significant decrease in the growth rate, thus PepN seems to play a more prominent role than do the other proteases (Contreras-Rodriguez et al., 2003).
COG COG0308E, under E: Amino acid transport and metabolism
References
Contreras-Rodriguez et al., 2003: Contreras-Rodriguez A, Ramirez-Zavala B, Contreras A, Schurig GG, Sriranganathan N, Lopez-Merino A. Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis. Infection and immunity. 2003; 71(9); 5238-5244. [PubMed: 12933870].