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omp19 from Brucella melitensis biovar Abortus 2308

Victor ID 1729
Gene Name omp19 from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788831
NCBI Protein GI 82700695
Locus Tag BAB1_1930
Protein Accession YP_415269.1
Other Database IDs UniProtKB-ID: OMP19_BRUA2
UniRef100: UniRef100_Q2YLR6
UniRef90: UniRef90_Q2YLR6
UniRef50: UniRef50_Q2YLR6
UniParc: UPI0000057B74
EMBL: U35742
EMBL: AM040264
EMBL-CDS: AAB04100.1
EMBL-CDS: CAJ11886.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1930
eggNOG: NOG28507
HOGENOM: HBG348791
OMA: LAKVSAW
ProtClustDB: CLSK864010
BioCyc: BMEL359391:BAB1_1930-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1877306
Gene Ending Position 1877839
Gene Strand (Orientation) -
Protein Name lipoprotein Omp19
DNA Sequence 
>gi|82698932:1877306-1877839 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
ATCAGCGCGACAGCGTCACGGCCTGCCCGCCGGTGGTCTGGCCATCGAAGCGGCCCTGTCCTGAAGAATA
GAGCGAGGCAACCGTACCGCCGTTCGCATCGTAAAGGACGAGTTGCTTGCCATTGACGGCCCAGGAGGCA
AGATTAGCCAGTTCACCGGGGCAGCGCAGCGGGCCTGCGCGATAGCCCTGGCCATATTTGGTCTGCGGCG
TCGCGATCTTGCAGCTCTGACCACCAAGCGAGGCGTTCCAGACGCCAGCCACGGCGCCGGGCGTCAGGTC
CGGTGCGGATGCAGGCGGCAGGCTTGCGACCTGTGTGCCGGATTGCGCGCTCATATCCGTGGAGGGCGCA
TTGGGGAATTGTGTGGGAGAATCAAGATTGCCTTTCTGCACCGTGCCTGCCGGAACAGCATTGACCGGTG
CAGGCGGCGGCGGAGGCGAAACATTATCGAGATTACCAAGCCGGGAGCTCTGGCACCCGGCCAGGACAAT
GCCAGCCGCCGCGAGGCTGAGCAGACTTGCTTTTGAAATTCCCA
Protein Sequence 
>gi|82700695|ref|YP_415269.1| lipoprotein Omp19 [Brucella abortus 2308] MGISKASLLSLAAAGIVLAGCQSSRLGNLDNVSPPPPPAPVNAVPAGTVQKGNLDSPTQFPNAPSTDMSAQSGTQVASLPPASAPDLTPGAVAGVWNASLGGQSCKIATPQTKYGQGYRAGPLRCPGELANLASWAVNGKQLVLYDANGGTVASLYSSGQGRFDGQTTGGQAVTLSR
Molecule Role Virulence factor
Molecule Role Annotation SUBCELLULAR LOCATION: Outer membrane; lipid-anchor(UniProt: P0A3P2).

MISCELLANEOUS: Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle(UniProt: P0A3P2).

SIMILARITY: Belongs to the rhizobiaceae omp19 lipoprotein family(UniProt: P0A3P2).

MUTATION: Omp19 is an immunoreactive outer membrane lipoprotein. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B abortus (Tibor et al., 2002).
References
Tibor et al., 2002: Tibor A, Wansard V, Bielartz V, Delrue RM, Danese I, Michel P, Walravens K, Godfroid J, Letesson JJ. Effect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. Infection and immunity. 2002; 70(10); 5540-5546. [PubMed: 12228280].