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ntrY from Brucella melitensis biovar Abortus 2308

Victor ID 1728
Gene Name ntrY from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788818
NCBI Protein GI 82699957
Locus Tag BAB1_1139
Protein Accession YP_414531.1
Other Database IDs UniProtKB-ID: Q2YPW5_BRUA2
UniRef100: UniRef100_A9M5C9
UniRef90: UniRef90_A9M5C9
UniRef50: UniRef50_A5VQP0
UniParc: UPI00000DD4CE
EMBL: AM040264
EMBL-CDS: CAJ11095.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1139
eggNOG: COG5000
HOGENOM: HBG311288
OMA: RIVRPIR
ProtClustDB: CLSK862978
BioCyc: BMEL359391:BAB1_1139-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1106596
Gene Ending Position 1108920
Gene Strand (Orientation) -
Protein Name PAS domain:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal:Bacterial sensor prot...
DNA Sequence 
>gi|82698932:1106596-1108920 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
ATCAAATCACCTGTCCAGCTGTGTGCTTTTCGTCATTTCCCGAATCCGCATCGGATGGAATGGGGGGATC
CTCGGGAAAGACCATACGTATCATTGCGCCCCGGCCTGCGTGAAAATCCGCGGGCGCATCATGCAATTCA
AGATTACCGCCATGATCTTCAACAATCTTGCGAACGATTGCGAGGCCAAGGCCCGTTCCCTTTTCGCGGG
TCGTCATATAGGGTTCCAGCAGTTTCTGGCGATCATCGCCGGGCAAGCCCTTGCCGTTGTCGATCACATC
GACCACCAGTTGCCCATCCGCCCTGTAGGCGTGAATGCGGATATGCCCCTCGCCGCGCTCTTCCTTCGCA
ACCGCGTCAATGGCCTCGCTGGCATTCTTGATGACATTGCCGAAGGCCTGCCCGATCAGGCGGCTATCGA
ACGATCCAATCAGCTTTTCCGAACCGAAATCATTGTCGAAATGAATGTCGCTGCGGCTGACTTCAATCAG
GAACGAGGCTTCACGCAATGCTTCGCGCAGGTCCATATGCCGCATTTCCGGCTTGGGCATACGCGCAAAA
GCGGAGAACTCATCGACCATGCGGCCAATATCGCCGACCTGACGAATGATGGTGTCCGTGCACTGGTCGA
AAACCTCGCGATCCTCCGTGATGACCTTGCCATACCGGCGGCGGATGCGCTCTGCCGAAAGCTGGATCGG
CGTCAGCGGATTCTTGATTTCATGCGCGATGCGCCGCGCCACATCCGCCCATGCGGAAGAACGTTGCGCC
TGCACCAGATCGGTGATGTCGTCCACCGTCACCACATAGGAGTGATCCTCGGATTCGGCATCCTCGACCG
TTACCTGCACATTGAAGCTGCGGCTACCGCCGCCGCGCGCCATGCTCACCTGCTCGCGGTGCACGGTTCG
CCCCGTGGCGCGCGCCACCTCGAAAGCCTGCCCGACCTCCGGCGCGATGCTGGTAAGGCTTTTCCCGACC
GCATCTTCCGACGTTACGCCAAACATATGCTCCGCAGAGCGGTTGAGGATCGAAATCGACCCGTCATTCT
CAATACCGATAACCCCTGCCGTCACACCCGAAAGCACGGCTTCGGAGAAGCGGCGGCGCTCATCGATCTG
GTCCTTGGCGGAAATAAGTTCGTTGCGCTGGCTTTTCAGCTCGGCAACCATGTTGTTGAAAGTACCCGAC
AGCGCCCCCACATCGCCATCGGACGAGCGCACCGGCACCGAAACATCAAGATTGCCGGCAGCCACATCGT
CCGATGCGCCGATCAGCAGCCGGATTGGCCGCACCAGCCGGTCTGCAACGGCAATGCCCGTCCAGATGGC
CGACAGAAGCACGATCAGCGTCAGGCCGAAATAGAGCAAAGCGAAAGCAATCTGCGTCGGAATGCGGTTC
GCATCCATTTCCTGATAGCGCCTGGCATTGGCATTCATCAGATTGATGGCATCAAGAATTTGCGGCGGAA
CCGAACGCACCGTATAAAGATACATGTCGGGAATTTCGCGCATCTTGATGAGTGCACCGACGAAATTGGT
GTTTCCCGGCGGGATGATGACAGGCTTTCCGTCCGGTGCCTTTTCAAGCGAATCCTTCGTCGGCGGCGGC
AGATGGCTTTCCATGCCCGTATCGCTCTGCACGACGACATCGCCATTATCACGCACCAGAAATGCGCCCA
GCAAGGCGCGCCCACGCACCTGCAATGTCATCAACTGGATGAAACCGTTCCGGTCGAGGCTATAAATGGC
ACGCTGCGCATCCAGATCCTGCAACATCGAATAGGACGTGCTCTGGAGGTTCAACGCGGTTTCCTGAAGA
TAGGCTGTATAGAAATTCTGGGATGAACTGATGATGTCGCGTGTATTCTGGTCGAACCAGCGATCAAGGC
CCAGATTGAGGGTCACGGAAGCGACAATTGCCACCACGATTGCCGGAATGGCGGCAATCAGCGAAAACAG
GGCTACAATGCGCACATGCAGGCGCGACGCGGCCTTGCCCAGCCTGCGCGCCGTTATGATGCGATAGACC
TCGCGGCAAATCAGCAGGATCAGAAACAAAATCAACGCGACATTGATAATCACCAGCGCCAGTGTAACCG
TGCGGTCGGGGGTGATTGGCGTAATACCGATCAGGATCGCGAAGGAAAACGAAGCTGTGACCAGCGCCGA
AACGACGGTAATAATACCCGGTAAGGCGAGAAGCCTGCGCCCCTCACCCTGCCCCTCATCTTGCGATGAT
TGCCTCGTCCCATTCATGTCGGTCGTCAGATTCGCCCTGTTCATGTTAACCATAATAACCAATAGCGTTG
CATCTATGCAACGCA
Protein Sequence 
>gi|82699957|ref|YP_414531.1| PAS/histidine kinase/ATPase domain-containing protein [Brucella abortus 2308] MRCIDATLLVIMVNMNRANLTTDMNGTRQSSQDEGQGEGRRLLALPGIITVVSALVTASFSFAILIGITPITPDRTVTLALVIINVALILFLILLICREVYRIITARRLGKAASRLHVRIVALFSLIAAIPAIVVAIVASVTLNLGLDRWFDQNTRDIISSSQNFYTAYLQETALNLQSTSYSMLQDLDAQRAIYSLDRNGFIQLMTLQVRGRALLGAFLVRDNGDVVVQSDTGMESHLPPPTKDSLEKAPDGKPVIIPPGNTNFVGALIKMREIPDMYLYTVRSVPPQILDAINLMNANARRYQEMDANRIPTQIAFALLYFGLTLIVLLSAIWTGIAVADRLVRPIRLLIGASDDVAAGNLDVSVPVRSSDGDVGALSGTFNNMVAELKSQRNELISAKDQIDERRRFSEAVLSGVTAGVIGIENDGSISILNRSAEHMFGVTSEDAVGKSLTSIAPEVGQAFEVARATGRTVHREQVSMARGGGSRSFNVQVTVEDAESEDHSYVVTVDDITDLVQAQRSSAWADVARRIAHEIKNPLTPIQLSAERIRRRYGKVITEDREVFDQCTDTIIRQVGDIGRMVDEFSAFARMPKPEMRHMDLREALREASFLIEVSRSDIHFDNDFGSEKLIGSFDSRLIGQAFGNVIKNASEAIDAVAKEERGEGHIRIHAYRADGQLVVDVIDNGKGLPGDDRQKLLEPYMTTREKGTGLGLAIVRKIVEDHGGNLELHDAPADFHAGRGAMIRMVFPEDPPIPSDADSGNDEKHTAGQVI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The NtrY protein is a sensor of an ntr-related regulon which may be part of the glnALG operon. This mutant has a weakly attenuated phenotype (reduction of 1.2 log units versus the wild type at 48 h postinfection) which could be explained by a pleiotropic effect on the ntr regulon, since the ntrC mutant did not show such a phenotype (Foulongne et al., 2000).
COG COG5000T, under T: Signal transduction mechanisms
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].