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ntrC from Brucella melitensis biovar Abortus 2308

Victor ID 1727
Gene Name ntrC from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788817
NCBI Protein GI 82699958
Locus Tag BAB1_1140
Protein Accession YP_414532.1
Other Database IDs UniProtKB-ID: Q2YPW4_BRUA2
UniRef100: UniRef100_A5VQP1
UniRef90: UniRef90_A5VQP1
UniRef50: UniRef50_Q04848
UniParc: UPI00000DD4CF
EMBL: AM040264
EMBL-CDS: CAJ11096.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1140
eggNOG: COG2204
HOGENOM: HBG740884
OMA: TAIKASE
ProtClustDB: CLSK898235
BioCyc: BMEL359391:BAB1_1140-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1109011
Gene Ending Position 1110486
Gene Strand (Orientation) -
Protein Name CbxX/CfqX superfamily:Response regulator receiver:Sigma-54 factor interaction domain:Helix-turn-helix, Fis-type:AAA ATPase
DNA Sequence 
>gi|82698932:1109011-1110486 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
GCTAACCGCCGGTCTTTGCGCCACGATAGATATTGACGCCGAGTTCGCGGATTTTCTTGCGCAACGTATT
CCGGTTAAGTCCTAAAAGATCGGCGGCCTTGATCTGGTTGCCGCGGGTGGCCGTCAGGCAGGCAAGGATC
AGCGGATATTCCACTTCAGCCAGAACACGCTGATAAAGCCCCGGCGGCGGCAGATCCGAACCGAACGAAG
CGAAATAGCGCTGCATGTTCTGCTCCACGGCTTGTGAAATGGAGATATTTTCCATCTCGCCGCCAGCAGC
GGCAACAACGTCCGGCTTGGCCAATTCGGCCTTGAGCTCGGTTTCGATGATTTCCGGCGCGATTTCTTCC
TGCGGATAGAGCGCGGCAAGCCTGCGCACGAGATTTTCAAGCTCGCGCACATTGCCCGGCCACGGATAGC
GCCGCATCATCTCCAGACCCGCATTGGTAATGCGCTTTTCGGGCAACCCCTCTTCCGCAGCGCGTTTGAA
GAAATGGCGCACGAGATCGGGGACATCCTCGCTTCGTTCGCGAAGCGGCGGCAGGCGCAGCGGCACTACA
TTCAAGCGGTAGTAGAGGTCTTCGCGGAAAAGCCCCTGCGCGATGATCTGTCGTAAATCCCTGTTGGTGG
CGGCAACGATGCGCACATCGGTCTTGATCGGCGTGCGCCCGCCAACGGTCATATATTCGCCCTGTTGCAG
CACGCGCAGAAGGCGCGTTTGCGCCTCCATCGGCATATCGCCAATTTCGTCCAGAAACAGCGTACCGCCA
TTGGCCTGCTCAAAGCGCCCGCTCGACCGGTTCTGTGCGCCGGTGAATGCTCCCTTTTCGTGCCCGAACA
GTTCCGATTCGATAAGGTCACGCGGGATTGCAGCCATATTGATCGCCACGAACGGTCCCTTGCGGCGGCG
GCCATATTCATGCAGGGCACGCGCGACGAGTTCCTTGCCGGTGCCGGATTCACCCGTCACCATGACGGTG
AGGTCTGTCTGCATCATGCGCGCCAGAAGACGGTAGATTTCCTGCATGGCGGGCGAACGGCCCACAAGGG
GCATGTTCTCCCCCTGCTCGTCGGGAAGCGCCACGGCAGGCTTCTGCCTGGGTTCCGAGAGCGCGCGCCC
TACGATATTGATAAGCTCGGTCAGATCGAACGGCTTTGGCAGATACTCATAAGCCCCCGCCTCGGAAGCG
CGGATTGCGGTCATGAATGTGTTCTGCGCGCTCATGACCACAACGGGCAGATCGGGGCGTATCTTCTTGA
TGCGCGGCAAGAGATCGAATGCATTTTCATCGGGCATCATGACATCGCTGATCACCAGATCGCCATCGCC
CGCCGCAACCCAGCGCCAGAGCGATGCGGCATTGGACGTCACCCGCACATCATAACCAGCACGGGACAAT
GCCTGATTGAGCACCGTGCGAATGGCTGCATCGTCGTCTGCCACCAGTACAGTTCCAGTCGGACGCCCTG
CAATCA
Protein Sequence 
>gi|82699958|ref|YP_414532.1| response regulator receiver [Brucella abortus 2308] MIAGRPTGTVLVADDDAAIRTVLNQALSRAGYDVRVTSNAASLWRWVAAGDGDLVISDVMMPDENAFDLLPRIKKIRPDLPVVVMSAQNTFMTAIRASEAGAYEYLPKPFDLTELINIVGRALSEPRQKPAVALPDEQGENMPLVGRSPAMQEIYRLLARMMQTDLTVMVTGESGTGKELVARALHEYGRRRKGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSSGRFEQANGGTLFLDEIGDMPMEAQTRLLRVLQQGEYMTVGGRTPIKTDVRIVAATNRDLRQIIAQGLFREDLYYRLNVVPLRLPPLRERSEDVPDLVRHFFKRAAEEGLPEKRITNAGLEMMRRYPWPGNVRELENLVRRLAALYPQEEIAPEIIETELKAELAKPDVVAAAGGEMENISISQAVEQNMQRYFASFGSDLPPPGLYQRVLAEVEYPLILACLTATRGNQIKAADLLGLNRNTLRKKIRELGVNIYRGAKTGG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ntrC encodes for a response regulator subfamily (NtrC). A B suis ntrC isogenic mutant was constructed which showed no significant differences in growth rates compared to the wild-type strain when grown at different temperatures in vitro. However, the mutant exhibited a reduction in metabolic activity in the presence of many amino acids. The mutation did not affect survival or multiplication of B suis in macrophages, but during the initial stages of infection in the murine brucellosis model, the ntrC mutant showed a reduced ability to multiply rapidly in splenic tissue (Dorrell et al., 1999).
COG COG2204T, under T: Signal transduction mechanisms
References
Dorrell et al., 1999: Dorrell N, Guigue-Talet P, Spencer S, Foulonge V, O'Callaghan D, Wren BW. Investigation into the role of the response regulator NtrC in the metabolism and virulence of Brucella suis. Microbial pathogenesis. 1999; 27(1); 1-11. [PubMed: 10373105].