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lysA from Brucella melitensis biovar Abortus 2308

Victor ID 1726
Gene Name lysA from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788788
NCBI Protein GI 82700743
Locus Tag BAB1_1984
Protein Accession YP_415317.1
Other Database IDs UniProtKB-ID: Q2YR85_BRUA2
UniRef100: UniRef100_A5VSV3
UniRef90: UniRef90_A5VSV3
UniRef50: UniRef50_Q9KVL7
UniParc: UPI00000DD755
EMBL: AM040264
EMBL-CDS: CAJ11940.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1984
eggNOG: COG0019
HOGENOM: HBG672375
OMA: SIAGKCC
ProtClustDB: CLSK863778
BioCyc: BMEL359391:BAB1_1984-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1923420
Gene Ending Position 1924685
Gene Strand (Orientation) +
Protein Name Orn/DAP/Arg decarboxylase, family 2:ATP/GTP-binding site motif A (P-loop):Diaminopimelate decarboxylase
DNA Sequence 
>gi|82698932:1923420-1924685 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CGTGAACCACTTTGAATATCGCAACGGCGTTCTCCACGCTGAAAATGTCAGCCTGCCCGAAATAGCCAAG
GCCGTCGGCACGCCTTTCTATGTCTATTCGCGCGCAACCATCGAGCGCCATTTTCGCGTGTTCCATGACG
CCTTTGCCGATATGGACACGCTCGTCACCTATGCGCTGAAGGCGAATTCCAACCAGGCTGTGCTGACGGC
GCTGGCAAAGCTTGGCGCGGGCGCGGACACGGTTTCGCAGGGCGAGATCCGCCGTGCGCTTGCCGCGGGC
ATTCCGGCAAACAGGATTGTATTTTCCGGCGTCGGCAAGACCCCGCGCGAAATGGATTTTGCGCTGGAAG
CTGGCATTTACTGTTTCAACGTCGAATCCGAGCCGGAGCTGGAAATTCTTTCAGCCCGCGCCGTCGCCGC
CGGCAAGGTGGCGCCTGTCTCGCTGCGTATCAACCCGGATGTGGATGCGAAGACCCACGCGAAAATCTCC
ACCGGCAAGTCGGAGAACAAGTTCGGCATCCCGCGCGACAAGGCGCGCGCGGCCTATGCCCGCGCGGCAA
GCCTGCCCGGCCTCAACGTCGTCGGCATCGACATGCACATCGGAAGCCAGATCATCGATCTTGAGCCTTT
CGACAATGCTTTCGCGCTGATGGCGGAACTGGTGAAGGAATTGCAGGCCGATGGCCACAATATCCGCCAT
GTCGATGTGGGCGGCGGGCTGGGCATTCCCTACCGCACCGACAACACGCCGCCGCCGCCACCTGTTGCCT
ATGCCCAAATAGTGGCGAAACACATCAAGCCGCTCGGCCTCAAGACCGTGTTTGAGCCGGGCCGCCTGAT
CGTCGGCAATGCCGGGCTTCTCGTGACGGAAGTAATTTTCGTGAAGGAAGGCGATGCGAAGAATTTCGTG
ATCGTGGACGCGGCGATGAACGATCTCATCCGCCCGACGCTTTACGATGCCTTTCACGATATCAGGCCGG
TCATTATGCCGAACGACAATGCCCCGCGCATCCGCGCCGATTTCGTCGGTCCGGTCTGCGAGACGGGCGA
CTATCTGGGCCTCGACCGCGAGGTGGCAAAGCCCGCCCCCGGCGACCTGATCGCCATCTGCACCACCGGC
GCTTATGGCGCGGTGCTTTCCAGCACCTATAACAGCCGCCTTCTCATTCCCGAAGTGCTGGTGGACGGCG
AGCGTTACCATGTGGTTCGTCCGCGCCGCACCTATGAGGAACTGCTGGCGCTCGATTCCGTGCCGGACTG
GCTGTA
Protein Sequence 
>gi|82700743|ref|YP_415317.1| diaminopimelate decarboxylase [Brucella abortus 2308] MNHFEYRNGVLHAENVSLPEIAKAVGTPFYVYSRATIERHFRVFHDAFADMDTLVTYALKANSNQAVLTALAKLGAGADTVSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALEAGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHAKISTGKSENKFGIPRDKARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQADGHNIRHVDVGGGLGIPYRTDNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFVKEGDAKNFVIVDAAMNDLIRPTLYDAFHDIRPVIMPNDNAPRIRADFVGPVCETGDYLGLDREVAKPAPGDLIAICTTGAYGAVLSSTYNSRLLIPEVLVDGERYHVVRPRRTYEELLALDSVPDWL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis lysA gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0019E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].