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hisD

Victor ID 1720
Gene Name hisD
Sequence Strain (Species/Organism) Brucella
NCBI Gene ID 3788752
NCBI Protein GI 82699185
Locus Tag BAB1_0285
Protein Accession YP_413759.1
Other Database IDs UniProtKB-ID: HISX_BRUA2
UniRef100: UniRef100_Q2YPB8
UniRef90: UniRef90_Q2YPB8
UniRef50: UniRef50_Q46WL2
UniParc: UPI00004F8EC2
EMBL: AM040264
EMBL-CDS: CAJ10241.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0285
eggNOG: COG0141
HOGENOM: HBG329596
OMA: ARDRIEF
ProtClustDB: PRK00877
BioCyc: BMEL359391:BAB1_0285-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 279950
Gene Ending Position 281242
Gene Strand (Orientation) -
Protein Name histidinol dehydrogenase
DNA Sequence 
>gi|82698932:279950-281242 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CTCATAGGTTCAGACGAATGGCGACGGATTGGGCATGGGCATCGAGACCCTCGGCGCGTGCAATCTCGAT
CGCAGCCGGTCCAAGTGCGCGAAGCTGCTCGGAGCCCAGCTTGAGAAGCGAGGTGCGCTTCATATAATCG
AGCACCGAAAGGCCGGAGGAGAAACGGGCAGAGCGCGCCGTTGGCAGCACATGGTTGCAGCCCCCCACAT
AATCGCCGATCACTTCCGGTGTATAACCGCCAATGAATATGGAACCGGCATTGCGGATGCGCGGTACGAA
CGCCTCCGCATCGGCCACGGCGATTTCCAGATGCTCGGCCGCAATACGGTTGGCAAGCGGAATTGCGTCC
TCGAAATCCTTGACCAGAATGACCGCACCGAAATCGCGCCAGCTTGCGGAAGCCGTTTCAGTGCGCGCCA
GGGTGTGAAGCTGCCGTTCGACCGCTTCTTCCACCGCGTGGGCAAAGGCCTCGTCATTGGTCATCAGGAT
GGATTGCGCGGCCATATCGTGCTCGGCCTGTGCCAGAAGATCGGCGGCGATCCAGTCCGGGTTATTGTCC
TTGTCGGCCACGATCAGCACTTCGGATGGCCCGGCGATCATGTCGATGCCGACCGTTCCGAATACGATGC
GCTTTGCCGCTGCCACATAGGCATTGCCGGGGCCGACGATCTTGGCGACGGGACGGATCGTTTCGGTGCC
ATAGGCAAGGGCGGCAATGGCCTGCGCGCCGCCGACGCGGTAAATCTCCGACACGCCTGCAAGGCGGGCT
GCCACCAGCACCAGCGGATTGAGATTGCCATCGGGTGCGGGCACCACCATGACGATGCGGTCCACGCCTG
CGACCTTGGCGGGCATCGCATTCATCAGAACGGAACTTGGATAGCTGGCCGTGCCGCCAGGCACATAGAG
GCCGACAGCCTCGATGGCCGTCCAGCGCGAGCCAAGCTCGACGCCAAGCGCATCCGTATAGCGGTCGTCC
TTCGGCAACTGGCGAGCATGGTGCTTTTCGATACGGTCGCGCGCAAGCTTCAATGCTTCGACGGTGGAGG
CGGGAGCGGCATCGAATGCGGCATCGATCTCGGCCTCGGTGACGGCAATGCCGGTCTTTTCCAGATCGAT
CCGGTCGAAGCGGCGTGAATAATCGAGCAGCGCGCTGTCACCCTCGCGGCGTACACGATCCACGATTTCC
CGCACGGCGCGGTCCACATCTTCCGAAACCTCGCGCTTGCCGGAGAGGAAGGCCGCAAACTTCTGTTCAA
AATCAGGGTCGGTCTGTCTGAGCGTTGTGACCA
Protein Sequence 
>gi|82699185|ref|YP_413759.1| histidinol dehydrogenase [Brucella abortus 2308] MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDMAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNL
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity)(UniProt: Q8G2R2).

CATALYTIC ACTIVITY: L-histidinol + 2 NAD(+) = L-histidine + 2 NADH(UniProt: Q8G2R2).

COFACTOR: Binds 1 zinc ion per subunit (By similarity)(UniProt: Q8G2R2).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9 [final step](UniProt: Q8G2R2).

SIMILARITY: Belongs to the histidinol dehydrogenase family(UniProt: Q8G2R2).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis hisD gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0141E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].