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hisC from Brucella melitensis biovar Abortus 2308

Victor ID 1719
Gene Name hisC from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788751
NCBI Protein GI 82700747
Locus Tag BAB1_1988
Protein Accession YP_415321.1
Other Database IDs UniProtKB-ID: HIS8_BRUA2
UniRef100: UniRef100_Q2YR81
UniRef90: UniRef90_Q2YR81
UniRef50: UniRef50_A7ICA9
UniParc: UPI00000DD758
EMBL: AM040264
EMBL-CDS: CAJ11944.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1988
eggNOG: COG0079
HOGENOM: HBG646350
OMA: NPANILC
ProtClustDB: PRK02731
BioCyc: BMEL359391:BAB1_1988-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1929102
Gene Ending Position 1930199
Gene Strand (Orientation) +
Protein Name histidinol-phosphate aminotransferase
DNA Sequence 
>gi|82698932:1929102-1930199 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CATGCAGAAACCTACCCGTCCCCAGCCCAAGGCAGGCGTGCTTGACATTGCAGCCTATGTACCCGGCAAG
GAACATGTGGAAGGCGTTGCCAAGGTCTATAAGCTCTCCTCCAACGAAACCCCGCTTGGACCAAGCCCCC
ATGCCAGGGAAGCCTACCGGCATGCGGGCGAAAAGCTTGAGCTTTACCCGGACGGGCAGGCACTGGCGCT
GCGGCAGGCGATTGCGGAAACGCAGGGGCTCAACATTTCCAACATTCTGTGCGGCAACGGATCCGACGAA
TTGCTGGGCCTTCTCTGCCAGACCTATCTTGCCCCCGGTGACGAAACCATCATCACCGAGCACGGCTTTG
CCGTTTACAAGATCCAGACGCTCGCAGCCGGCGCCACCCCCGTCACGGTGAAGGAAAAGAACGAACGCAT
CGATGTGGACGCCATCCTCGCAGGTGTGACGGCGCGCACAAAAATCGTCTTCATCGCCAATCCGGCCAAC
CCGACCGGCACTTATCTGCCTTTTGAGGAAGTGCGCCGCCTCCATGCGGGCCTGCCGCAGCATGTTCTGC
TGGTGCTCGACGCCGCCTATGCCGAATATGTGCGCCGCAACGATTATGAAGCCGGGCTGGAACTCGTTTC
ATCCAATGAAAACGTGGTGATGACGCGCACTTTCTCGAAGATTCACGGCCTGCCCGGCCTGCGCATCGGC
TGGATTTATGCGCCGCTCCACATCATCGACGCCATGAACCGCATCCGCGGCCCCTTCAACATGAATTCCG
CCGCGATTGCTGCGGGCGCCGCCGCGATCCGCGATCGTGCACATGTCGAAAAATCGGTCGCCTATAACGA
GAAATGGCTTGCCTGGCTCACGGAAGAATTCACCAGGCTCGGTCTGCGGGTTACACCTTCCGTGACGAAC
TTCCTGCTCATTCATTTCCCCGATGATGCCGCCCATTCGGCAGACAAGGCCGATGAATGGCTATCGAGGC
GCGGCTATATTCTCCGCCGTGTCGGGGGCTATGGTTTCCCCAATGCACTGCGCATGACGGTGGGACCAGA
AGAAGCCAATCGCGGTGTGGTAGCCGCCCTCACAGAATTTCTGAAGTA
Protein Sequence 
>gi|82700747|ref|YP_415321.1| histidinol-phosphate aminotransferase [Brucella abortus 2308] MQKPTRPQPKAGVLDIAAYVPGKEHVEGVAKVYKLSSNETPLGPSPHAREAYRHAGEKLELYPDGQALALRQAIAETQGLNISNILCGNGSDELLGLLCQTYLAPGDETIITEHGFAVYKIQTLAAGATPVTVKEKNERIDVDAILAGVTARTKIVFIANPANPTGTYLPFEEVRRLHAGLPQHVLLVLDAAYAEYVRRNDYEAGLELVSSNENVVMTRTFSKIHGLPGLRIGWIYAPLHIIDAMNRIRGPFNMNSAAIAAGAAAIRDRAHVEKSVAYNEKWLAWLTEEFTRLGLRVTPSVTNFLLIHFPDDAAHSADKADEWLSRRGYILRRVGGYGFPNALRMTVGPEEANRGVVAALTEFLK
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate(UniProt: Q8FY98).

COFACTOR: Pyridoxal phosphate (By similarity)(UniProt: Q8FY98).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7(UniProt: Q8FY98).

SUBUNIT: Homodimer (By similarity)(UniProt: Q8FY98).

SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily(UniProt: Q8FY98).

MUTATION: hisC encodes for histidinol phosphate transaminase. Brucella hisC mutant showed very little reduction in number by 2 weeks post-inoculation, but was reduced by 8 weeks.
COG COG0079E, under E: Amino acid transport and metabolism
References