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glyA from Brucella melitensis biovar Abortus 2308

Victor ID 1716
Gene Name glyA from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788734
NCBI Protein GI 82699646
Locus Tag BAB1_0787
Protein Accession YP_414220.1
Other Database IDs UniProtKB-ID: GLYA_BRUA2
UniRef100: UniRef100_B2S513
UniRef90: UniRef90_A6X1Y9
UniRef50: UniRef50_A4SFY3
UniParc: UPI00004F8FB8
EMBL: AM040264
EMBL-CDS: CAJ10743.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0787
eggNOG: COG0112
HOGENOM: HBG301263
OMA: GRAYVTC
ProtClustDB: PRK00011
BioCyc: BMEL359391:BAB1_0787-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 768621
Gene Ending Position 769937
Gene Strand (Orientation) +
Protein Name serine hydroxymethyltransferase
DNA Sequence 
>gi|82698932:768621-769937 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CATGTCTCAAGCCAACGCCGCCACGAAAGCGTATTCGGACGTTTTCTTCAATGCAAGCCTCGAGGACATC
GATCCCGAGATTTTCGGTGCAATCCGCAACGAACTTGGTCGCCAGCGCCATGAAATCGAGCTGATCGCTT
CGGAAAACATCGTTTCGCGCGCTGTTCTGGAAGCACAGGGTTCCATCCTCACCAACAAATATGCCGAAGG
CTATCCGGGCAAGCGCTATTATGGCGGCTGCCAGTATGTCGATGTCGTGGAAGAACTGGCGATCGAACGC
GCCAAGAAGCTTTTCGGTGCCGAATTCGCCAATGTTCAGCCGAATTCCGGCAGCCAGATGAATCAGGCGG
TTTTCCTCGCGCTGCTTCAGCCAGGCGATACCTTCATGGGCCTCGACCTTAATTCAGGTGGCCACCTGAC
CCACGGTTCGCCGGTCAATATGTCCGGCAAGTGGTTCAATGTCGTGTCCTACGGCGTGCGCAAGGACGAT
CATCTGCTCGACATGGACGAAGTCGCCCGCCTCGCACGCGAAAACAAGCCCAAGCTTATCCTTGCAGGCG
GCACGGCCTATTCGCGTATCTGGGACTGGAAGCGTTTCCGCGAGATCGCCGATGAAGTGGGCGCTTATCT
CATGGTCGATATGGCGCATATTGCCGGTCTCGTGGCTGGCGGTCAGCATCCGTCGCCGGTTCCCCATGCC
CATGTCTGCACCACGACAACGCACAAATCGCTTCGCGGTCCGCGCGGCGGCATGATCCTCACCAATGATG
CCGATATTGCCAAGAAGATCAATTCGGCTGTCTTCCCCGGCCTTCAGGGCGGCCCGCTGATGCATGTCAT
CGCCGGTAAGGCTGTTGCCTTTGCCGAGGCGTTGAAGCCTGAGTTCAAGCTCTATGCGAAGAATGTGGTG
GATAACGCCCGTGCGCTTGCCGAGGAATTGAAGTCGCACGGCCTCGACATTGTTTCGGGCGGCACCGACA
ACCATCTCATGCTGGTCGATCTGCGCCCGAAGAACGCAACCGGCAAGCGGGCGGAAGCCGCTCTCGGACG
CGCCAACATCACCTGCAACAAGAACGGCATTCCCTTCGACCCTGAAAAGCCGTTTGTGACCTCCGGCGTC
CGTCTTGGCACGCCTGCCGGCACCACGCGCGGCTTCGGCGTTGCGGAATTCAAGGAAATCGGTTCGCTGA
TCGCCGAGGTTCTCGACGGTTTGAAGGTCGCCAATTCCGACGAAGGCAATGCGGCTGTCGAACAGGCCGT
GAAGGAAAAGGTCATCGCTCTGACCGGCCGTTTCCCGATGTACGGCTATCAGGGATA
Protein Sequence 
>gi|82699646|ref|YP_414220.1| serine hydroxymethyltransferase [Brucella abortus 2308] MSQANAATKAYSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGCQYVDVVEELAIERAKKLFGAEFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRKDDHLLDMDEVARLARENKPKLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTTHKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAKNVVDNARALAEELKSHGLDIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEVLDGLKVANSDEGNAAVEQAVKEKVIALTGRFPMYGYQG
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Interconversion of serine and glycine(UniProt: Q8G1F1).

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine(UniProt: Q8G1F1).

COFACTOR: Pyridoxal phosphate (By similarity)(UniProt: Q8G1F1).

PATHWAY: Key enzyme in the biosynthesis of purines, lipids, hormones and other components(UniProt: Q8G1F1).

SUBUNIT: Homotetramer (By similarity)(UniProt: Q8G1F1).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G1F1).

SIMILARITY: Belongs to the SHMT family(UniProt: Q8G1F1).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis glyA gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0112E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].