Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

bacA from Brucella melitensis biovar Abortus 2308

Victor ID 1711
Gene Name bacA from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788635
NCBI Protein GI 82699288
Locus Tag BAB1_0402
Protein Accession YP_413862.1
Other Database IDs UniProtKB-ID: Q2YMA1_BRUA2
UniRef100: UniRef100_A5VNV7
UniRef90: UniRef90_C0RH86
UniRef50: UniRef50_Q08120
UniParc: UPI00000AEA21
EMBL: AM040264
EMBL-CDS: CAJ10358.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0402
eggNOG: COG1133
HOGENOM: HBG289932
OMA: TMRFSST
ProtClustDB: PRK11098
BioCyc: BMEL359391:BAB1_0402-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 402046
Gene Ending Position 403293
Gene Strand (Orientation) +
Protein Name transport protein
DNA Sequence 
>gi|82698932:402046-403293 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CGTGTTTGCGTCATTTTTCCCCCGTCCGAAACTGTTCTTCATATCTGCACTTTTGTGGACCCTGCTCGCA
GTTCTTGGCTGGTATATGGGCGGTGAAAATCTGGGCAGCGTGTTCGGCCTTGCGCCAGCCGCAAGCGATG
CCGCGCCTCTCATTGGCGCGCATGTGTTCTGGTCGCGGCCCTTCCTCTGGTTCTATATTTATTTCGCCGT
CATTACCTTCGCCTTTTATGGCTTCTGGGTGCGTTTTTCCCCACATCCCTGGCAGAGATGGTCAATCCTC
GGTTCTGCCCTCATTCTGTTCGCCACCTATTTCAACGTTCAGGTGAGTGTGGCAATCAATACTTGGTATG
GCCCGTTCTACGATATGGTGCAGAAGGGGCTGACGACGCCCGGCGCGGTCTCGGCTGCGGAATTCTACTG
GGGGCTGGCCGATTTTGCAGGCATTGCTTTCCTCGCCATCACCATTGGCGTGCTGAACCTCTTCTTCGTC
AGCCATTATATCTTCCGCTGGCGCACGGCGATGAACGATTATTACATGAGCCATTGGCCGAAATTGCGCC
ATATCGAGGGTGCGGCCCAGCGTGTGCAGGAAGATACGATGCGCTTTTCCACCACGCTGGAACAGCTGGG
CGTCAGCCTCGTGAAATCCGTCATGACCCTCATCGCCTTCCTGCCCGTCCTGTTCACCTTTTCCCAAAAG
GTCAGCACGCTGCCGATCATCGGCTATGTTCCCCATGCGCTGGTCTGGGCGGCGGTCATCTGGGCGCTGT
TCGGTACCGGCTTCCTGGCGCTGGTGGGCATCAAGCTGCCCGGTCTGGAGTTCAACAACCAGCGGGTCGA
GGCCGCCTACCGTAAGGAACTCGTCTATGGCGAAGACCATGCCGACCGTGCTGAACCGATCACGATGCGC
GAACTGTTCAAGAATGTCCGGCACAATTATTTCCGGCTTTATTTCCACTATGTCTATTTCAATGTGGCGC
GCATTTTCTATTTGCAGGTGGACAATATCTTTCCGCTCATCATCCTGATCCCGTCGATTGTCGCGGGCAA
GCTGACGCTTGGCCTGATGAGCCAGATTACCAACGTGTTCGATCAGGTGCGCGGATCGTTCCAGTATCTG
GTCAATTCATGGACGACGATCATCGAGCTTCTGTCGATCTACAAGCGCCTTCGCGCCTTTGAGGCAGCCA
TTCATGGCGAGCCGCTACAGGCGGTGGATCGGATCAATCTCGAACCAGGGGCGGGCTG
Protein Sequence 
>gi|82699288|ref|YP_413862.1| transporter [Brucella abortus 2308] MFASFFPRPKLFFISALLWTLLAVLGWYMGGENLGSVFGLAPAASDAAPLIGAHVFWSRPFLWFYIYFAVITFAFYGFWVRFSPHPWQRWSILGSALILFATYFNVQVSVAINTWYGPFYDMVQKGLTTPGAVSAAEFYWGLADFAGIAFLAITIGVLNLFFVSHYIFRWRTAMNDYYMSHWPKLRHIEGAAQRVQEDTMRFSTTLEQLGVSLVKSVMTLIAFLPVLFTFSQKVSTLPIIGYVPHALVWAAVIWALFGTGFLALVGIKLPGLEFNNQRVEAAYRKELVYGEDHADRAEPITMRELFKNVRHNYFRLYFHYVYFNVARIFYLQVDNIFPLIILIPSIVAGKLTLGLMSQITNVFDQVRGSFQYLVNSWTTIIELLSIYKRLRAFEAAIHGEPLQAVDRINLEPGAG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B abortus bacA mutant exhibited decreased survival in macrophages and greatly accelerated clearance from experimentally infected mice compared to the virulent parental strain (LeVier et al., 2000). R meliloti bacA gene encodes a putative cytoplasmic membrane transport protein required for symbiosis (LeVier et al., 2000). The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells , respectively. Mutation study showed that B. abortus BacA affects the distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the alpha-proteobacteria(LeVier et al., 2000).
COG COG1133I, under I: Lipid transport and metabolism
References
LeVier et al., 2000: LeVier K, Phillips RW, Grippe VK, Roop RM 2nd, Walker GC. Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival. Science (New York, N.Y.). 2000; 287(5462); 2492-2493. [PubMed: 10741969].