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aspC from Brucella melitensis biovar Abortus 2308

Victor ID 1710
Gene Name aspC from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788626
NCBI Protein GI 82700306
Locus Tag BAB1_1514
Protein Accession YP_414880.1
Other Database IDs UniProtKB-ID: Q2YRM6_BRUA2
UniRef100: UniRef100_A5VRM9
UniRef90: UniRef90_D0B9T8
UniRef50: UniRef50_Q1RGV0
UniParc: UPI00004F911B
EMBL: AM040264
EMBL-CDS: CAJ11470.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_1514
eggNOG: COG0436
HOGENOM: HBG645860
OMA: IGKTAPS
ProtClustDB: PRK05764
BioCyc: BMEL359391:BAB1_1514-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 1466939
Gene Ending Position 1468141
Gene Strand (Orientation) +
Protein Name aspartate aminotransferase
DNA Sequence 
>gi|82698932:1466939-1468141 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CATGGCATTTCTCGCCGACGCCCTTTCCCGTGTAAAGCCATCTGCGACCATCGCTGTCAGCCAGAAAGCA
CGTGAACTGAAAGCAAAAGGCAAGGACGTGATCGTCCTGGGCGCAGGTGAGCCGGATTTCGACACGCCTG
AAAATATCAAGCAGGCGGCCATTGCCGCGATCAATCGCGGTGAAACAAAGTACACGCCCGTATCCGGCAT
CCCGCAACTGCGCCAGGCCATCGTCTCCAAGTTCAAGCGTGAAAACGGCCTCGACTACAAGCCGGAACAG
ACCATCGTCGGCACCGGCGGCAAGCAGATTTTGTTCAACGCCTTCATGGCCACGCTGAACCCCGGCGACG
AAGTCATCATTCCCGCCCCCTATTGGGTCAGCTACCCGGAAATGGTGGCCATCAACGGCGGCACCCCGGT
TTTCGTCGACACGAAGATTGAAGACAATTTCAAGCTGACCGCTGCCGATCTCGAAAAGGCGATCACACCG
AAGACCAAGTGGCTCATCTTCAACTCGCCCTCCAACCCGACCGGCGCGGCCTATACGCAAGCCGAACTGA
AGTCGCTGACCGACGTTCTCGTGCGCCATCCGCATGTCTGGATCTTGACCGACGACATGTATGAGCATCT
GGTCTATGGCGATTTCGTCTTCACGACGCCTGCTCAGGTGGAACCCTCGCTCTATGACCGTACGCTCACC
ATGAACGGCGTTTCCAAGGCCTATGCCATGACCGGCTGGCGCATCGGCTATGCCGCCGGTCCAATCGAGC
TCATCAAGGCCATGGACATGATTCAGGGGCAGCAGACCTCCGGTGCCTGCTCGATTGCTCAGTGGGCAGC
GGTCGAAGCACTGAACGGCACGCAGGATTTCATCCCCGCGAACAAGAAAATCTTCCAGGCCCGCCGCGAT
CTGGTCGTTTCCATGCTCAACCAGGCAACCGGCCTCCAGTGCCCGACGCCGGAAGGCGCGTTCTATGTCT
ATCCGTCCTGCGCAGGGCTGATCGGCAAGAAGACCGAAGCGGGCAAAGTCATCGAAACCGACAAAGATTT
TGTGACGGAACTTCTGGAAACCGAAGGCGTGGCGGTTGTTCATGGTTCGGCATTCGGCCTCGGCCCGAAC
TTCCGCATTTCCTATGCAACCTCGGATGAGCTGCTGGAAAAAGCCTGCATACGCATCCAGCGTTTCTGCG
CCAGCCTGCGCTG
Protein Sequence 
>gi|82700306|ref|YP_414880.1| aspartate aminotransferase [Brucella abortus 2308] MAFLADALSRVKPSATIAVSQKARELKAKGKDVIVLGAGEPDFDTPENIKQAAIAAINRGETKYTPVSGIPQLRQAIVSKFKRENGLDYKPEQTIVGTGGKQILFNAFMATLNPGDEVIIPAPYWVSYPEMVAINGGTPVFVDTKIEDNFKLTAADLEKAITPKTKWLIFNSPSNPTGAAYTQAELKSLTDVLVRHPHVWILTDDMYEHLVYGDFVFTTPAQVEPSLYDRTLTMNGVSKAYAMTGWRIGYAAGPIELIKAMDMIQGQQTSGACSIAQWAAVEALNGTQDFIPANKKIFQARRDLVVSMLNQATGLQCPTPEGAFYVYPSCAGLIGKKTEAGKVIETDKDFVTELLETEGVAVVHGSAFGLGPNFRISYATSDELLEKACIRIQRFCASLR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: aspC encodes for an aminotransferase. B.abortus aspC mutant obtained from randomized miniTn5Km2 transposon mutagenesis showed decreased intracellular survival inside HeLa cells. So B. abortus aspC gene is essential for HeLa cell intracellular growth (Kim et al., 2003).
COG COG0436E, under E: Amino acid transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].