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aroC from Brucella melitensis biovar Abortus 2308

Victor ID 1709
Gene Name aroC from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3788622
NCBI Protein GI 82699340
Locus Tag BAB1_0454
Protein Accession YP_413914.1
Other Database IDs UniProtKB-ID: AROC_BRUA2
UniRef100: UniRef100_B2S9R7
UniRef90: UniRef90_B2S9R7
UniRef50: UniRef50_Q2Y7L8
UniParc: UPI00000580C8
EMBL: AM040264
EMBL-CDS: CAJ10410.1
RefSeq_NT: NC_007618.1
HSSP: P63611
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0454
eggNOG: COG0082
HOGENOM: HBG292336
OMA: SRFTTQR
ProtClustDB: PRK05382
BioCyc: BMEL359391:BAB1_0454-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 446290
Gene Ending Position 447384
Gene Strand (Orientation) +
Protein Name chorismate synthase
DNA Sequence 
>gi|82698932:446290-447384 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CATGTCTCATAATAGTTTCGGTCATCTATTCCGCGTAACCACTTGGGGCGAAAGCCACGGTCTGGCGCTT
GGTTGCGTCGTGGATGGCTGCCCCCCCGGAATTACCTTCACCGAAGCCGAAATCCAGTCCTTTCTCGACA
AGCGCAAGCCGGGCCAGTCGAAATATACCACGCAGCGCCGCGAGCCGGATCAGGTGCGCGTGCTTTCCGG
CGTGCTTCTGGGCGAGGATGGTGTGACCATGACCACCACCGGCACGCCCATCTCCATGATGATCGAAAAT
ACCGATCAGCGTTCCAAGGATTATGGCGAGATCGCCCGGCAATACCGTCCCGGCCATGCCGATTACGCCT
ATGATGTGAAATATGGCATTCGTGATTATCGCGGCGGCGGACGGTCTTCCGCACGCGAAACGGCGGCGCG
TGTGGCGGCGGGTGCCATTGCCCGCAAGGTCGTTCCGGGACTGGAAGTCAGGGGCGCACTCGTTTCCATC
GGTGCGCACGATATCGACCGCAGCCGCTGGAACTGGGCGGAAGTGGACAATAATCCCTTCTTCACGCCGG
ATGCCGGTTCGGTGGAGGTTTTCGCCGACTATCTCGACGGTATCCGCAAGAACGGCTCATCGGTCGGTGC
GATCATCGAAATCGTGGCCGAGGGTGTACCGGCTGGCATCGGTGCGCCGATCTACGGCAAGCTGGATCAG
GATATCGCGAGCTATCTCATGTCGATCAACGCCGTGAAGGGCGTGGAAATCGGCAATGGCTTCGAGGCTG
CGCGCCTCACCGGCGAGGAAAATGCCGATGAAATGCGCATGGGCAATGACGGCAAGCCGATTTTTCTTTC
CAATCATGCGGGCGGTGTTCTGGGCGGCATAGCAACGGGCGCGCCGGTGGTGGCGCGTTTTGCGGTCAAG
CCAACGTCATCGATCCTCACGCCGCGCCGTTCCATCGATAAGGACGGCAATGAGGTTGATGTGATGACGA
GGGGCCGTCACGATCCGTGCGTGGGCATCCGCGCCGTGCCGATCGGTGAGGCCATGGTTGCCTGCGCCAT
TGCCGATCACTATCTGCGCCACCGCGGCCAGACTGGCCGCGTCTG
Protein Sequence 
>gi|82699340|ref|YP_413914.1| chorismate synthase [Brucella abortus 2308] MSHNSFGHLFRVTTWGESHGLALGCVVDGCPPGITFTEAEIQSFLDKRKPGQSKYTTQRREPDQVRVLSGVLLGEDGVTMTTTGTPISMMIENTDQRSKDYGEIARQYRPGHADYAYDVKYGIRDYRGGGRSSARETAARVAAGAIARKVVPGLEVRGALVSIGAHDIDRSRWNWAEVDNNPFFTPDAGSVEVFADYLDGIRKNGSSVGAIIEIVAEGVPAGIGAPIYGKLDQDIASYLMSINAVKGVEIGNGFEAARLTGEENADEMRMGNDGKPIFLSNHAGGVLGGIATGAPVVARFAVKPTSSILTPRRSIDKDGNEVDVMTRGRHDPCVGIRAVPIGEAMVACAIADHYLRHRGQTGRV
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate(UniProt: P63608).

COFACTOR: Reduced flavin (By similarity)(UniProt: P63608).

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 7 [final step](UniProt: P63608).

PATHWAY: Context: Aromatic amino acids biosynthesis(UniProt: P63608).

SUBUNIT: Homotetramer (By similarity)(UniProt: P63608).

SIMILARITY: Belongs to the chorismate synthase family(UniProt: P63608).

MUTATION: The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in it issue culture (THP1 macrophages and HeLa cells) and murine virulence models (Foulongne et al., 2001).
COG COG0082E, under E: Amino acid transport and metabolism
References
Foulongne et al., 2001: Foulongne V, Walravens K, Bourg G, Boschiroli ML, Godfroid J, Ramuz M, O'Callaghan D. Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models. Infection and immunity. 2001; 69(1); 547-550. [PubMed: 11119550].