Victors

uvrA from Brucella melitensis biovar Abortus 2308
Victor ID	1707
Gene Name	uvrA from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism)	Brucella melitensis biovar Abortus 2308
NCBI Gene ID	3787776
NCBI Protein GI	82699947
Locus Tag	BAB1_1128
Protein Accession	YP_414521.1
Other Database IDs	UniProtKB-ID: UVRA_BRUA2 UniRef100: UniRef100_Q2YPX5 UniRef90: UniRef90_Q2YPX5 UniRef50: UniRef50_Q2YPX5 UniParc: UPI00004F905C EMBL: AM040264 EMBL: L10843 EMBL-CDS: CAJ11084.1 EMBL-CDS: AAA16817.1 RefSeq_NT: NC_007618.1 GenomeReviews: AM040264_GR KEGG: bmf:BAB1_1128 eggNOG: COG0178 HOGENOM: HBG284763 OMA: GAIKGWD ProtClustDB: PRK00349 BioCyc: BMEL359391:BAB1_1128-MONOMER
Taxonomy ID	359391
Chromosome No	I
Gene Starting Position	1092052
Gene Ending Position	1094976
Gene Strand (Orientation)	+
Protein Name	excinuclease ABC subunit A
DNA Sequence	>gi\|82698932:1092052-1094976 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence AATGAGCGATCAGAAATTCATTTCCATACGTGGCGCACGCGAGCACAATCTGAAAAATGTCGATCTCGAT CTGCCGCGCGACAAGCTGATCGTGATGACGGGGCTTTCTGGCTCGGGCAAATCCTCGCTTGCTTTCGATA CGATCTATGCCGAAGGCCAGCGCCGCTATGTCGAAAGCCTTTCAGCCTATGCGCGTCAGTTTCTCGAAAT GATGCAGAAACCGGATGTCGACCAGATTGACGGCCTGTCGCCCGCCATTTCCATCGAGCAGAAGACGACA AGCCGCAATCCGCGTTCGACGGTGGGCACAGTCACCGAAATCTACGACTATATGCGCCTGCTCTTTGCGC GTGTGGGCATTCCCTATTCTCCTGCTACCGGCCTTCCGATCGAAAGCCAGACGGTGAGCCAGATGGTCGA TAGGGTCATCGCACTGGAGGAAGGCACACGTCTTTATATCCTTGCGCCTATCGTGCGCGGGCGTAAGGGC GAATACAGGAAGGAACTCGCCGAACTTCAGAAAAAGGGCTTCCAGCGCGTGAAGGTGGACGGCACCTTCT ATGAGATCGCCGACGTTCCGCCACTCGACAAGAAATACAAGCACGATATCGACGTAGTGGTAGACCGCGT GGTGGTGCGCCCGGATTTGTCCACACGTCTTGCAGACAGTCTCGAAACCTGTCTCAAGCTTGCGGATGGT CTGGCCATTGCCGAATTTGCCGACAAGCCCCTGCCAGTGGGAGAAACGGCGGAAGGCGGTTCAGCCAATA AATCAGCCAACGAAACGCATGAGCGCATTCTTTTCTCGGAAAAATTTGCCTGCCCGGTTTCCGGTTTCAC CATTCCTGAGATCGAGCCGCGCCTGTTCTCGTTCAACAACCCGTTTGGTGCCTGCCCCACCTGCGACGGT CTCGGCACGCAGCAGGCCATCGATCCAAACCTTATTATTCCCGATGAAAGCGCAGCGCTGAAAGACGGCG CGGTTGCACCATGGGCGCGCTCCTCGTCGCCCTATTACAACCAGACGCTGGAAGCCTTGGGCAAGGCCTA TGGTTTCAAGGTAAGCGCGCGCTGGTCGGAACTTTCCGAAGAGGCCCGGCAAGCCATTCTCTATGGCACC AAGGGCAGGGAAATTACCTTCCATTATGACGACGGGCTGCGGTCTTATCAAACCACGAAGCCTTTCGAGG GGGTGATCCCCAATCTGGAACGCCGCTGGAAGGAAACCGATTCGGCATGGTCGCGTGAGGAAATCGAGCG CTTCATGGCCTCCACCCCCTGCCCCGCCTGCAATGGCTATCGCCTGAAGCCGGAAGCCCTGTCCGTAAAG ATCGGCAAAAAACATATTGGCGAGATCACCGAAATGTCGATCCGCAAGGCCGATGCCTGGTTCCGCGACA TCGATGGCAGCTTTAATGAAAAGCAGCGTGAAATTGCAGCGCGCATCCTGAAAGCAATTCGCGAGCGCCT GCAATTCCTCAACAATGTGGGGCTCGACTACCTGACGCTGGCGCGCAATTCCGGCACGCTCTCTGGCGGC GAAAGCCAGCGTATCCGCCTTGCCTCGCAGATCGGCTCGGGCCTCACCGGCGTGCTTTACGTGCTGGATG AACCATCCATTGGTTTGCATCAGCGTGATAATGCCCGCCTGCTCGACACGCTGCGCCACCTGCGCGATCT CGGTAATACGGTCATCGTGGTCGAGCATGATGAGGACGCAATCCTCACCGCCGATTATGTGGTCGATATC GGCCCGGCAGCGGGCGTGCATGGCGGCAAGGTGATTGCGCAGGGCTCGCCCCAGGATATCATGGCAAATA CGAATTCGCTGACAGGCAAATATCTGTCCGGCGCGATGGAAGTTGCCGTCCCGGCCGAGCGTCGCAAAAT TTCCAAGACCAAGCGCCTGCGTGTCGTGGGCGCTCGGGGCAACAACCTGAAGAATGTTTCAGCCGATATT CCACTCGGCACCTTCACCGCTGTCACGGGCGTTTCAGGCGGAGGCAAGTCCACCTTCCTGATCGAGACGT TGTTCAAGGCTGCGTCGCGCCGCATCATGGGGTCGCGTGAGCATCCGGCTGAACACGACCGGATAGAGGG GCTGGAATTTCTCGACAAGGTGATTGACATTGACCAGTCACCGATCGGGCGCACCCCGCGCTCCAACCCG GCCACCTATACCGGTGCGTTCACACCAATCCGCGACTGGTTTGCGGGCCTGCCGGAAGCCAAGGCGCGCG GCTATCAGCCGGGCCGCTTTTCCTTCAACGTCAAGGGCGGGCGCTGCGAGGCATGTCAGGGCGACGGCGT CATCAAGATCGAGATGCACTTCCTGCCAGACGTTTATGTGACCTGCGATGTCTGCCACGGCAAGCGGTAT AACCGCGAAACACTGGATGTGCTGTTCAAGGGCAAGTCCATTGCCGATGTTCTCGACATGACAGTGGAAG AAGGTGCTGAATTCTTCTCCGCCGTGCCGGCCGTGCGCGACAAGCTGGAAACGCTCGTCAAGGTCGGCCT CGGTTACATCAAGGTCGGCCAGCAGGCGACGACGCTTTCCGGCGGCGAAGCGCAGCGTGTGAAGCTTGCC AAGGAACTGTCGCGCCGCGCAACTGGCCGCACGCTCTATATTCTTGACGAACCCACCACCGGCCTGCATT TCCACGACGTAGCAAAACTGCTCGAAGTGCTGCACGAACTGGTGGAGCAAGGAAACACGGTCGTTGTGAT CGAGCATAATCTGGAAGTCATCAAGACTGCCGACTGGGTGATCGACCTTGGACCGGAAGGTGGCGACGGC GGCGGCGAGATTGTTGCCGTGGGCCGTCCGGAAGACATTGTGCAGGAGAAGCGGTCTTATACCGGCCAAT TCCTCAAGGAGCTGCTGGAACGCCGGCCCAAGCGCAGCTCCCAAGCTGCCGAGTA
Protein Sequence	>gi\|82699947\|ref\|YP_414521.1\| excinuclease ABC subunit A [Brucella abortus 2308] MSDQKFISIRGAREHNLKNVDLDLPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLEMMQKPDVDQIDGLSPAISIEQKTTSRNPRSTVGTVTEIYDYMRLLFARVGIPYSPATGLPIESQTVSQMVDRVIALEEGTRLYILAPIVRGRKGEYRKELAELQKKGFQRVKVDGTFYEIADVPPLDKKYKHDIDVVVDRVVVRPDLSTRLADSLETCLKLADGLAIAEFADKPLPVGETAEGGSANKSANETHERILFSEKFACPVSGFTIPEIEPRLFSFNNPFGACPTCDGLGTQQAIDPNLIIPDESAALKDGAVAPWARSSSPYYNQTLEALGKAYGFKVSARWSELSEEARQAILYGTKGREITFHYDDGLRSYQTTKPFEGVIPNLERRWKETDSAWSREEIERFMASTPCPACNGYRLKPEALSVKIGKKHIGEITEMSIRKADAWFRDIDGSFNEKQREIAARILKAIRERLQFLNNVGLDYLTLARNSGTLSGGESQRIRLASQIGSGLTGVLYVLDEPSIGLHQRDNARLLDTLRHLRDLGNTVIVVEHDEDAILTADYVVDIGPAAGVHGGKVIAQGSPQDIMANTNSLTGKYLSGAMEVAVPAERRKISKTKRLRVVGARGNNLKNVSADIPLGTFTAVTGVSGGGKSTFLIETLFKAASRRIMGSREHPAEHDRIEGLEFLDKVIDIDQSPIGRTPRSNPATYTGAFTPIRDWFAGLPEAKARGYQPGRFSFNVKGGRCEACQGDGVIKIEMHFLPDVYVTCDVCHGKRYNRETLDVLFKGKSIADVLDMTVEEGAEFFSAVPAVRDKLETLVKVGLGYIKVGQQATTLSGGEAQRVKLAKELSRRATGRTLYILDEPTTGLHFHDVAKLLEVLHELVEQGNTVVVIEHNLEVIKTADWVIDLGPEGGDGGGEIVAVGRPEDIVQEKRSYTGQFLKELLERRPKRSSQAAE
Molecule Role	Virulence factor
Molecule Role Annotation	FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity)(UniProt: Q8G0I9). SUBUNIT: Forms a heterotetramer with uvrB during the search for lesions (By similarity)(UniProt: Q8G0I9). SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G0I9). SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily(UniProt: Q8G0I9). SIMILARITY: Contains 2 ABC transporter domains(UniProt: Q8G0I9). MUTATION: B. abortus urvA and recA mutants exhibited greater sensitivity than the wild-type strain. Mutant strains carrying inactivated uvrA genes are typically less sensitive than recA mutants because there is only the loss of the nucleotide excision repair system, just one subset of the larger repair networks. However, it was found that the recA mutant conferred only a modest sensitivity to UV, substantially less sensitive than the uvrA mutant. High basal recA expression was observed in the uvrA repair mutant. The B abortus recA mutant exhibited a nearly fourfold decline in survival to murine peritoneal macrophages but nominal sensitivity for the uvrA and radA repair mutants (Roux et al., 2006).
COG	COG0178L, under L: Replication, recombination and repair
References	*Roux et al., 2006:* Roux CM, Booth NJ, Bellaire BH, Gee JM, Roop RM 2nd, Kovach ME, Tsolis RM, Elzer PH, Ennis DG. RecA and RadA proteins of Brucella abortus do not perform overlapping protective DNA repair functions following oxidative burst. Journal of bacteriology. 2006; 188(14); 5187-5195. [PubMed: 16816190].


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uvrA from Brucella melitensis biovar Abortus 2308