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tig from Brucella melitensis biovar Abortus 2308

Victor ID 1706
Gene Name tig from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3787589
NCBI Protein GI 82699768
Locus Tag BAB1_0917
Protein Accession YP_414342.1
Other Database IDs UniProtKB-ID: TIG_BRUA2
UniRef100: UniRef100_B2S5D1
UniRef90: UniRef90_B2S5D1
UniRef50: UniRef50_B2S5D1
UniParc: UPI0000E5711C
EMBL: AM040264
EMBL-CDS: CAJ10873.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0917
eggNOG: COG0544
HOGENOM: HBG635105
ProtClustDB: PRK01490
BioCyc: BMEL359391:BAB1_0917-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 889519
Gene Ending Position 890958
Gene Strand (Orientation) +
Protein Name trigger factor
DNA Sequence 
>gi|82698932:889519-890958 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
AATGACAAGAAGTGAAGGTTTGAACATGCAGGTTACCGAAACGCTCAATGAAGGGCTGAAGCGCGAGATC
AAAGTCGTGGTTCCGGCCGGGGATCTTGAAGCCAAGCTCGCTGAGCGGCTCGAAACCGCGCGCGGCCGCG
CCCGCATCAACGGCTTCCGTCCGGGCAAGGTGCCGACGGCTCACCTGCGCAAGATGTACGGCAAGTCCTT
CATGGCCGAGATCGTCAACGAAATCCTCAACGATTCGTCGCGTTCCATCCTTGCCGAACGCAACGAAAAG
TCGGCGACCCAGCCTGAAGTCATCATGTCGGAAGACGAAAAAGAAGCCGAGAAGGTTCTCGACGGCAAGG
CCGATTTCGTTTTCTCGCTGAACTATGAAGTGCTGCCGGCAATCGAGGTCAAGGACTTCTCCAAGATCGC
CGTGACCCGTGAAGTCGTCGACATTTCCGATGAGGAAGTCGATGAACAGGTCAAGCGCATTGCGTCGTCG
ACCCGCACCTTTGAAACCAAGAAGGGCAAGGCCGAAAACGAAGATCGCGTCACGATCGACTATCTGGGCA
AGCTCGACGGCGAGCCGTTTGAAGGCGGTGCAGACAATGACGCACAGCTCGTTCTCGGTTCCGGCCAGTT
CATTCCGGGCTTTGAAGAACAGCTCATTGGCTTGAAGGCTGGCGACGAGAAGGTCATCACCGTAACGTTC
CCGGCTGAATACGGCGCTGCGCATCTGGCTGGCAAGGAAGCAACCTTCGACATCAAGGTGAAGGAAGTTG
CCAAGCCGAACGAACTCGTTCTCGATGACGAAACCGCAAAGAAGCTCGGCATTGAGTCGCTTGAGCGTCT
GCGTCAGGTTGTGCGCGAACAGATCGAAAGCCAGTACGGCCAGATCACCCGCCAGAAAGTGAAGCGTCAG
ATTCTCGACGCCCTTGATGGTGATTATCAGTTTGAAACCCCGCAGAAGCTGGTTGACGCCGAGTTCAACA
ACATCTGGCAGCAGATCAACTTCGACCTGCAGCAGGCTGGCCGCACTTTTGAAGACGAGGAAACGACGGA
AGAAGCTGCTCGCGAAGAATATCGCAAGCTTGCAGAACGCCGCGTTCGTCTTGGCCTCGTTCTCTCCGAA
ATCGGCGAGAAGGCAGGCGTGGAAGTGACCGAAGAAGAACTGCAGCGCGCTGTTTACGATCAGGTTCGCC
GCTATCCGGGTCAGGAAAAGGAAATCTACGACTTCCTGCGCCGTACGCCGGATGCCGTCGCCAATCTGCG
CGCGCCGATCTTTGAAGAAAAGGTCGTCGATCATCTGCTGGCCAACATCAATGTGACCGACAAGAAGGTC
TCGAAGGAAGAGCTGACGGCTGAAGACGAAGATGCAGCATCGGAAGCAAAGCCTGCCAAGAAGGCGGCTG
CGAAGAAGAAGGCCGAAGAAGGCAAGTCCGAAGAGGCTTG
Protein Sequence 
>gi|82699768|ref|YP_414342.1| trigger factor [Brucella abortus 2308] MTRSEGLNMQVTETLNEGLKREIKVVVPAGDLEAKLAERLETARGRARINGFRPGKVPTAHLRKMYGKSFMAEIVNEILNDSSRSILAERNEKSATQPEVIMSEDEKEAEKVLDGKADFVFSLNYEVLPAIEVKDFSKIAVTREVVDISDEEVDEQVKRIASSTRTFETKKGKAENEDRVTIDYLGKLDGEPFEGGADNDAQLVLGSGQFIPGFEEQLIGLKAGDEKVITVTFPAEYGAAHLAGKEATFDIKVKEVAKPNELVLDDETAKKLGIESLERLRQVVREQIESQYGQITRQKVKRQILDALDGDYQFETPQKLVDAEFNNIWQQINFDLQQAGRTFEDEETTEEAAREEYRKLAERRVRLGLVLSEIGEKAGVEVTEEELQRAVYDQVRRYPGQEKEIYDFLRRTPDAVANLRAPIFEEKVVDHLLANINVTDKKVSKEELTAEDEDAASEAKPAKKAAAKKKAEEGKSEEA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation (By similarity)(UniProt: Q8G129).

SIMILARITY: Belongs to the FKBP-type PPIase family. Tig subfamily(UniProt: Q8G129).

SIMILARITY: Contains 1 PPIase FKBP-type domain(UniProt: Q8G129).

MUTATION: tig encodes for Trigger factor that helps protein folding and secretion. It is one of the attenuated Signature-Tagged Mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice (Lestrate et al., 2003).
COG COG0544O, under O: Posttranslational modification, protein turnover, chaperones
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].