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pgi from Brucella melitensis biovar Abortus 2308

Victor ID 1705
Gene Name pgi from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3787092
NCBI Protein GI 82699210
Locus Tag BAB1_0316
Protein Accession YP_413784.1
Other Database IDs UniProtKB-ID: G6PI_BRUA2
UniRef100: UniRef100_B2S928
UniRef90: UniRef90_B2S928
UniRef50: UniRef50_A9M7X1
UniParc: UPI00004F8ECE
EMBL: AM040264
EMBL-CDS: CAJ10272.1
RefSeq_NT: NC_007618.1
GenomeReviews: AM040264_GR
KEGG: bmf:BAB1_0316
eggNOG: COG0166
HOGENOM: HBG352954
OMA: GPKIVSQ
ProtClustDB: PRK00179
BioCyc: BMEL359391:BAB1_0316-MONOMER
Taxonomy ID 359391
Chromosome No I
Gene Starting Position 312047
Gene Ending Position 313696
Gene Strand (Orientation) +
Protein Name glucose-6-phosphate isomerase
DNA Sequence 
>gi|82698932:312047-313696 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence
CATGGCAAGAGACGCGACGAAGCTTGAAGCAACGGTCGCAAAGCTGAAAAAGCATTGGGCGGAATCGGCC
CCGCGCGATATGCGCGCGGCATTCAGCACCGACCCCGGCCGGTTCGGGCGATATTCGCTCTGCCTGGATG
ATCTTCTGTTCGACTGGTCGAAGTGCCGGGTTAACGACGAGACCATGGCGCTGTTGAAAGAGCTGGCCGT
CGCTGCCGATGTGGAAGGGCGCCGCGCCGCCATGTTCGCGGGCGAGCATATCAACAATACCGAAGACCGC
GCCGTTCTGCATGTGGCGCTGCGCGACACGTCCTCGAAGGAAGTGCTGGTTGACGGGCATAATGTACTGC
CGGATGTGAAACATGTGCTCGACCGCATGGCCGCTTTTGCGGATGGCATCCGGTCCGGCGCGTTGAAGGG
CGCGACCGGCCGGAAGATTACCGATATCGTGAATATCGGCATTGGCGGTTCCGATCTGGGGCCTGTCATG
GCGACGCTGGCGCTTGCGCCCTATCATGATGAGCCACGCGCGCATTTCGTTTCCAATATCGATGGCGCGC
ATATTGCCGACACGCTTTCGCCGCTTGATCCGGCATCGACGCTTATCATTGTCGCGTCGAAGACTTTTAC
GACCATTGAAACCATGACGAACGCGCAGACGGCGCGCAAATGGGTGGCAGACACCCTGGGCGAGGCGGCG
GTGGGCGCGCATTTTGCTGCCGTTTCCACTGCGCTCGACAAGGTTGCGGCCTTCGGCATTCCTGAAGATC
GTGTTTTCGGCTTCTGGGACTGGGTTGGCGGGCGTTATTCGGTCTGGTCGGCCATCGGCCTGCCGGTGAT
GATCGCCGTCGGCCCGGATAATTTCCGCAAGTTCCTTGCGGGCGCACACGCCATGGATGTGCATTTCCGC
GATGCGCCACTGGAAAAGAACCTGCCCGTCATGCTCGGCCTCATCGGCTATTGGCATCGCGCAATCTGCG
GTTATGGCAGCCGCGCCATCATTCCTTATGACCAGCGCCTTTCGCGCCTCCCGGCCTATTTGCAGCAGCT
CGATATGGAATCGAACGGCAAGAGCGTGACGCTGGATGGCAAGCCGGTTTCCGGCCCAACCGGCCCCGTT
GTCTGGGGTGAGCCCGGCACCAATGGCCAGCACGCCTTTTTCCAGCTTCTGCATCAGGGAACCGATACGA
TCCCGCTGGAATTCATCGTGGCGGCCAAGGGCCACGAGCCGACACTGGATCACCAGCATGAAATGCTGAT
GGCAAACTGCCTTGCCCAGTCCGAAGCCCTGATGAAAGGCCGCACGCTGGACGAGGCGCGTGCGCAGTTG
CAGGCAAAGAACCTGCCTGCGTCGCAAGTGGAGCGCATTGCCCCGCACCGCGTCTTTTCCGGCAACCGCC
CATCCCTGACGCTCATCCATGACATGCTCGACCCCTATGCGCTGGGTCGCCTGATCGCGCTTTACGAACA
TCGTGTTTTCGTCGAAGCGCAGATTTTCGGCATCAATGCCTTCGATCAATGGGGCGTGGAACTGGGTAAG
GAACTGGCGACGGAACTTTTGCCGGTTGTATCGGGCAAGGAAGGGGCGAGTGGTCGCGACGCTTCCACGC
AAGGGCTTGTCGCGCATCTGCATGCGCGAAGGAAAGCTTG
Protein Sequence 
>gi|82699210|ref|YP_413784.1| glucose-6-phosphate isomerase [Brucella abortus 2308] MARDATKLEATVAKLKKHWAESAPRDMRAAFSTDPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDEPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRKA
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6-phosphate(UniProt: Q8G2N3).

PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2(UniProt: Q8G2N3).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G2N3).

SIMILARITY: Belongs to the GPI family(UniProt: Q8G2N3).

MUTATION: B. suis pgi is a gene identified by signature-tagged mutagenesis. The mutant is attenuated inside THP1 macrophages. The mutation of the pgi gene could also affect the biosynthesis of the bacterial peptidoglycan (Foulongne et al., 2000).
COG COG0166G, under G: Carbohydrate transport and metabolism
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].