Victors

metH from Brucella melitensis biovar Abortus 2308
Victor ID	1704
Gene Name	metH from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism)	Brucella melitensis biovar Abortus 2308
NCBI Gene ID	3786978
NCBI Protein GI	82699102
Locus Tag	BAB1_0188
Protein Accession	YP_413676.1
Other Database IDs	UniProtKB-ID: Q2YP51_BRUA2 UniRef100: UniRef100_B2S8I0 UniRef90: UniRef90_B0CJ47 UniRef50: UniRef50_B3QGP3 UniParc: UPI00004F8E8C EMBL: AM040264 EMBL-CDS: CAJ10144.1 RefSeq_NT: NC_007618.1 GenomeReviews: AM040264_GR KEGG: bmf:BAB1_0188 eggNOG: COG1410 HOGENOM: HBG289648 OMA: YVTDASR ProtClustDB: PRK09490 BioCyc: BMEL359391:BAB1_0188-MONOMER
Taxonomy ID	359391
Chromosome No	I
Gene Starting Position	194905
Gene Ending Position	198690
Gene Strand (Orientation)	+
Protein Name	B12-dependent methionine synthase
DNA Sequence	>gi\|82698932:194905-198690 Brucella melitensis biovar Abortus 2308 chromosome I, complete sequence TATGGCGTCTTCCCTTGACGATCTTTTTGGTGCAACGGCGGCAAAGCCGGACGGTTCGGAAGTGCTGGCG GCACTGACCCAGGCGGCGCGCGAGCGCATCCTGATCCTCGACGGCGCCATGGGTACGCAGATTCAGGGCC TGGGTTTCCATGAAGAGCATTTTCGCGGCGATCGTTTCGCCACCTGTGACTGCCAGCTTCAGGGCAATAA CGATCTTCTGACCTTGACCCAGCCGAAAGCCATTGAGGAAATCCACTATGCCTATGCCATGGCGGGCGCG GATATTCTCGAAACCAATACTTTCTCCTCCACTTCCATCGCGCAGGCCGATTATGGCATGGAGGCGATGG TCTATGATCTCAATCGCGATGGCGCACGCCTTGCCCGCCGCGCAGCCTTGCGCGCCGAGCAGAAGGACGG CCGCCGCCGCTTTGTCGCGGGCGCACTGGGGCCGACGAACCGCACCGCCTCGCTGTCCCCGGATGTGAAC AATCCGGGCTTTCGCGCCGTCACTTTCGATGATCTGCGCATTGCCTATTCCGAACAGATTCGCGGCCTGA TCGATGGCGGTTCCGACATCATCCTGATCGAAACCATTTTCGATACGCTGAACGCCAAGGCGGCTGTGTT CGCGACCGAGGAAGTCTTTGCCGAAAAGGGTGTTCGCCTTCCGGTCATGATCTCCGGTACGATCACCGAT CTTTCCGGGCGCACGCTTTCCGGCCAGACGCCGACGGCCTTCTGGTATTCACTGCGCCATGCAAGACCGT TCACCATCGGACTGAATTGCGCCCTCGGCGCCAATGCCATGCGTGCGCATCTGGATGAATTGTCGGGCAT TGCCGACACCTTTATCTGCGCCTATCCCAATGCCGGCCTTCCGAACGAATTCGGCCAGTATGATGAAACG CCGGAAGCCATGGCCGCGCAGATCGAGGGCTTTGCTCGCGACGGGCTGGTCAATGTTGTTGGCGGCTGCT GCGGCTCCACGCCTGACCATATTCGCGCCATCGCGCAAGCCGTCGCGAAATATGAGCCACGCAAGCCCGC AAAAGTGCCGCCGCTGATGCGCCTTTCCGGCCTTGAGCCCTTTACGCTCACCAAGGATATTCCTTTCGTC AATATCGGCGAGCGCACCAATGTCACCGGCTCGGCCCGCTTCCGCAAGCTCGTCAAGGCCGGCGATTTCG CGGCTGCGCTCGATGTTGCGCGCGATCAGGTGGCCAACGGCGCCCAGATCATCGATATCAACATGGATGA AGGCCTGATCGATTCCGAAAAGGCCATGGTCGAGTTTTTGAACCTTATTGCCGCCGAGCCGGATATCGCC CGCGTGCCGATCATGCTCGACAGCTCCAAATGGGAAGTGATCGAGGCTGGCCTGAAATGCGTTCAGGGCA AGGCAGTCGTCAATTCCATCTCGCTGAAAGAGGGTGAGGAAGCCTTTCTTCACCATGCGCGGCTGGTGCG TGCCTATGGTGCCGCTGTGGTCATCATGGCGTTCGATGAAACCGGACAGGCGGATACGCAGGCACGCAAG ATCGAAATCTGCACCCGCGCCTATAAAATCCTGACCGAACAGGTGGGTTTCCCGCCGGAAGACATCATTT TCGATCCGAATATTTTTGCGGTCGCGACCGGCATCGAGGAACACAATAATTACGGCGTCGATTTCATCGA GGCCACGCGTGAAATCGTCCGCACACTGCCGCATGTCCATATTTCCGGCGGCGTTTCCAACCTCTCGTTC TCCTTCCGCGGCAATGAGCCGGTGCGTGAGGCGATGCATGCCGTTTTCCTCTACCACGCCATTCAGGCGG GCATGGATATGGGCATCGTCAATGCGGGCCAGCTTGCGGTCTATGACACGATCGACGCTGAACTGCGTGA GGCTTGCGAGGATGTGGTGCTGAACCGCCCCACAAAAACGGGCGAAAGCGCAACCGAACGGCTTCTGGAA ATTGCCGAACGGTTCCGTGATTCCGGCTCCAGGGAAGCGCGGACGCAGGATTTGAGCTGGCGCGAATGGC CGGTCGAAAAGCGGCTTGAACATGCGCTGGTCAACGGCATCACCGAATATATCGAGGCCGATACGGAAGA GGCGCGCCTTGCTGCCGAGCGCCCGTTGCATGTGATCGAAGGGCCGCTGATGGCAGGCATGAATGTGGTC GGCGACCTGTTCGGTTCCGGCAAGATGTTTCTGCCGCAGGTGGTGAAATCTGCCCGCGTGATGAAGCAGG CCGTGGCCGTGCTGCTGCCCTTCATGGAAGAGGAAAAGCGCCTCAATGGCGGCGAGGGCCGCCAGAGTGC GGGCAAGGTGCTGATGGCGACCGTCAAGGGCGATGTGCACGATATCGGCAAGAATATCGTGGGCGTGGTT CTGGCCTGCAATAATTATGAAATCATAGATCTTGGCGTCATGGTGCCCTCGCAGAAAATCCTGCAGGTGG CGCGCGATGAAAAGGTGGATATCATCGGCCTTTCCGGCCTCATCACGCCTTCGCTTGATGAGATGGCGCA TGTCGCCGCCGAAATGGAGCGCGAGGGCTTCGATATTCCGCTTTTGATTGGCGGTGCGACGACGAGCCGT GTTCATACGGCGGTGAAAATCCATTCGCGTTACGAGCGCGGGCAGGCTGTCTATGTCGTGGATGCAAGTC GTGCGGTGGGGGTCGTGTCAAACCTCCTGTCGCCGGAGGGCAAGCAGGCCTATATCGACGGTTTACGCAA CGAATATGCCAAGGTGGCTGCTGCCCATGCCCGCAACGAGGCTGAAAAACAGCGCCTGCCAATTGCCCGC GCGCGCGCCAATCCGCATCAGCTCGACTGGGAAAACTACGAGCCGGTGAAGCCGGCCTTCACCGGAACGA AGGTTTTTGAAACCTATGATCTGGCGGAAATCGCGCGCTATATCGACTGGACCCCGTTCTTCCAGACCTG GGAACTGAGGGGCCGCTATCCGGCTATTCTCGAAGATGAAAAGCAGGGTGAGGCGGCGCGCCAGCTCTGG GCGGATGCGCAAGCGATGCTCCGGAAGATCATCGATGAGAAATGGTTCACCCCGCGGGCGGTGGTCGGCT TCTGGCCTGCCAATGCGGTGGGCGATGATATCCGCCTCTTTACGGATGAAAGCCGCAAGGAGGAGCTTGC CACCCTGTTCACGCTTCGCCAGCAGCTTACCAAGCGCGATGGCCGCCCGAATGTCGCCATGGCGGATTTT GTGGCGCCTGTCGAAAGCGGCAAACAGGATTATGTTGGCGGTTTTGTCGTGACGGCGGGCATTGGCGAGA TTGCTATCGCAGAGCGTTTTGAACGCGCCAATGATGATTATTCCGCCATTCTTGTGAAGGCGCTTGCCGA TCGTTTCGCGGAAGCCTTCGCGGAACTGATGCATGAGCGTGTGCGCAAGGAATTCTGGGCCTATGCGCCG GATGAAGCCTTTACGCCGGAAGAACTGATCAGCGAGCCATATAAGGGCATCCGCCCGGCGCCGGGCTATC CGGCCCAGCCCGATCATACGGAAAAGACCACCTTGTTCCGCCTGCTCGATGCCACCGCCAATACCGGCGT GGAGCTTACCGAAAGCTACGCCATGTGGCCCGGCTCCTCGGTGTCGGGTCTCTATATCGGTCACCCTGAA AGCTATTATTTCGGTGTGGCAAAGGTGGAGCGCGATCAGGTCGAGGATTATGCCCGGCGCAAGGACATGG ATGTGGAGGCTGTGGAGCGCTGGCTCACCCCGATCCTCAATTATGTCCCTGGGGCATCGAAAGACGAAGC GGCCTG
Protein Sequence	>gi\|82699102\|ref\|YP_413676.1\| B12-dependent methionine synthase [Brucella abortus 2308] MASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQPKAIEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSPDVNNPGFRAVTFDDLRIAYSEQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLSGQTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARDGLVNVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALDVARDQVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEEAFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIEATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPTKTGESATERLLEIAERFRDSGSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYEIIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVYVVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPAFTGTKVFETYDLAEIARYIDWTPFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALADRFAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWPGSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEAA
Molecule Role	Virulence factor
Molecule Role Annotation	FUNCTIONAL GROUP: a.a. metabolism, Synthesis (Delrue et al., 2004). FUNCTION: Met. synthesis (Delrue et al., 2004). MUTATION: Attenuated in Mice, Macrophages, HeLa (Delrue et al., 2004).
COG	COG1410E, under E: Amino acid transport and metabolism
References	*Delrue et al., 2004:* Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].


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metH from Brucella melitensis biovar Abortus 2308