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aroD from Shigella boydii CDC 3083-94

Victor ID 1674
Gene Name aroD from Shigella boydii CDC 3083-94
Sequence Strain (Species/Organism) Shigella boydii CDC 3083-94
NCBI Gene ID 6272464
NCBI Protein GI 187733855
Locus Tag SbBS512_E1896
Protein Accession YP_001880453.1
Other Database IDs UniProtKB-ID: AROD_SHIB3
UniRef100: UniRef100_B2U2J7
UniRef90: UniRef90_A7ZMF8
UniRef50: UniRef50_Q186A6
UniParc: UPI00005F23F5
EMBL: CP001063
EMBL-CDS: ACD10121.1
RefSeq_NT: NC_010658.1
EnsemblGenome: EBESCG00000074281
EnsemblGenome_TRS: EBESCT00000075234
EnsemblGenome_PRO: EBESCP00000072553
GenomeReviews: CP001063_GR
KEGG: sbc:SbBS512_E1896
HOGENOM: HBG732926
OMA: NHDFDKT
ProtClustDB: PRK02412
Taxonomy ID 344609
Gene Starting Position 1736318
Gene Ending Position 1737076
Gene Strand (Orientation) +
Protein Name 3-dehydroquinate dehydratase, type I
DNA Sequence 
>gi|187730020:1736318-1737076 Shigella boydii CDC 3083-94 chromosome, complete genome
AATGAAAACCGTAACTGTAAAAGATCTCGTCATTGGTACGGGCGCACCTAAAATCATCGTCTCGCTGATG
GCGAAAGATATCGCCCGCGTGAAATCCGAAGCTCTCGCCTATCGTGAAGCGGACTTTGATATTCTGGAAT
GGCGTGTGGACCACTTTGCCGACCTCTCCAATGTGGAGTCTGTCATGGCGGCGGCAAAAATTCTCCGCGA
AACCATGCCAGAAAAACCGCTGCTGTTTACCTTCCGCAGTGCCAAAGAAGGCGGCGAGCAGGCGATTTCC
ACCGAGGCTTATATTGCTCTCAATCGTGCAGCCATCGACAGCGGCCTGGTTGATATGATAGATCTGGAGT
TATTTACCGGCGATGATCAGGTTAAAGAAGCCGTCGCCTGCGCCCACGCGCATGATGTGAAAGTTGTCAT
GTCCAACCATGACTTCCATAAAACGCCGGAAGCCGAAGAAATCATTGCCCGTCTGCGCAAAATGCAGTCC
TTCAACGCCGATATTCCTAAGATTGCGCTGATGCCGCAAAGTACCAGCGATGTGCTGACGTTGCTTGCCG
CGACCCTGGAGATGCAGGAGCAGTATGCCGATCGTCCAATCATCACAATGTCAATGGCAAAAACTGGCGT
AATTTCTCGTCTGGCTGGTGAAGTATTTGGCTCGGCGGCAACTTTTGGTGCGGTAAAAAAAGCCTCTGCG
CCAGGGCAAATCTCGGTAAATGATTTACGCACAGTATTAACTATTTTACATCAGGCATA
Protein Sequence 
>gi|187733855|ref|YP_001880453.1| 3-dehydroquinate dehydratase [Shigella boydii CDC 3083-94] MKTVTVKDLVIGTGAPKIIVSLMAKDIARVKSEALAYREADFDILEWRVDHFADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKEAVACAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFNADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: aroD deletion led to attenuation in HeLa cells and monkeys (Kärnell et al., 1993).
COG COG0710E, under E: Amino acid transport and metabolism
References
Kärnell et al., 1993: Kärnell A, Cam PD, Verma N, Lindberg AA. AroD deletion attenuates Shigella flexneri strain 2457T and makes it a safe and efficacious oral vaccine in monkeys. Vaccine. 1993; 11(8); 830-836. [PubMed: 8356844].