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ipaH7.8 from Shigella sonnei Ss046

Victor ID 1638
Gene Name ipaH7.8 from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3671029
NCBI Protein GI 74314895
Locus Tag SSON_P058
Protein Accession YP_313313.1
Other Database IDs UniProtKB-ID: Q3YTT4_SHISS
UniRef100: UniRef100_Q3YTT4
UniRef90: UniRef90_P18014
UniRef50: UniRef50_Q31SH3
UniParc: UPI00005AACEB
EMBL: CP000039
EMBL-CDS: AAZ91078.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102126.
EnsemblGenome_TRS: EBESCT00000103082
EnsemblGenome_PRO: EBESCP00000098942
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P058
eggNOG: COG4886
HOGENOM: HBG673275
OMA: HISALIV
ProtClustDB: CLSK505000
BioCyc: SSON300269:SSO_P058-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 53670
Gene Ending Position 55367
Gene Strand (Orientation) +
Protein Name probably secreted by the Mxi-Spa machinery
DNA Sequence 
>gi|74314838:53670-55367 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
TATGTTCTCTGTAAATAATACACACTCATCAGTTTCTTGCTCCCCCTCTATTAACTCAAACTCAACCAGT
AATGAATATTATCTGAGAATCCTGACTGAATGGGAAAAGAACTCTTCTCCCGGGGAAGAGCGAGGCATTG
CTTTTAACAGACTCTCCCAGTGCTTTCAGAATCAAGAAGCAGTATTAAATTTATCAGACCTAAATTTGAC
GTCTCTTCCCGAATTACCAAAGCATATTTCTGCTTTGATTGTAGAAAATAATAAATTAACATCATTGCCA
AAGCTGCCTGCATTTCTCAAAGAACTTAATGCTGATAATAACAGGCTTTCTGTGATACCAGAACTTCCTG
AGTCATTAACAACTTTAAGTGTTCGTTCTAATCAACTGGAAAACCTTCCTGTTTTGCCAAACCATTTAAC
ATCATTATTTGTTGAAAATAACAGGCTATATAACTTACCGGCTCTTCCCGAAAAATTGAAATTTTTACAT
GTTTATTATAACAGGCTGACAACATTACCCGACTTACCGGATAAACTGGAAATTCTCTGTGCTCAGCGCA
ATAATCTGGTTACTTTTCCTCAATTTTCTGATAGAAACAATATCAGACAAAAGGAATATTATTTTCATTT
TAATCAGATAACCACTCTTCCGGAGAGTTTTTCACAATTAGATTCAAGTTACAGGATTAATATTTCAGGG
AATCCATTGTCGACTCGCGTTCTGCAATCCCTGCAAAGATTAACCTCTTCGCCGGACTACCACGGCCCGC
AGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATGCCGTGACAGC
ATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGAAGAGCATGCC
AACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTG
AACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGC
TGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTG
GTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGT
TCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGGATGAGATAGA
AGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAAGGAAATGCGT
TTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGAAGCCGTGAAG
AGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGA
CCGCTGGGCGCAGGCAGAAGAGCAGAAGTATGAGATGCTGGAGAATGAGTACTCTCAGAGGGTGGCTGAC
CGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTG
AGACTGAACAGCAGATTTACCGTCAGTTGACTGACGAGGTACTGGCCCTGCGATTGTCTGAAAACGGCTC
ACGACTGCACCATTCATA
Protein Sequence 
>gi|74314895|ref|YP_313313.1| invasion plasmid antigen [Shigella sonnei Ss046] MFSVNNTHSSVSCSPSINSNSTSNEYYLRILTEWEKNSSPGEERGIAFNRLSQCFQNQEAVLNLSDLNLTSLPELPKHISALIVENNKLTSLPKLPAFLKELNADNNRLSVIPELPESLTTLSVRSNQLENLPVLPNHLTSLFVENNRLYNLPALPEKLKFLHVYYNRLTTLPDLPDKLEILCAQRNNLVTFPQFSDRNNIRQKEYYFHFNQITTLPESFSQLDSSYRINISGNPLSTRVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSRLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH7.8 mutants had a lower rate of exit from the endocytic vacuoles into the cytoplasm in mouse macrophages than the wild-type strain (Fernandez-Prada et al., 2000).
COG COG4886S, under S: Function unknown
References
Fernandez-Prada et al., 2000: Fernandez-Prada CM, Hoover DL, Tall BD, Hartman AB, Kopelowitz J, Venkatesan MM. Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. Infection and immunity. 2000; 68(6); 3608-3619. [PubMed: 10816519].