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virK from Shigella sonnei Ss046

Victor ID 1632
Gene Name virK from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670925
NCBI Protein GI 74315018
Locus Tag SSON_P181
Protein Accession YP_313436.1
Other Database IDs UniProtKB-ID: Q3YTG1_SHISS
UniRef100: UniRef100_Q326Y6
UniRef90: UniRef90_Q08JR6
UniRef50: UniRef50_Q9X694
UniParc: UPI00000AFB9B
EMBL: CP000039
EMBL-CDS: AAZ91201.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102073.
EnsemblGenome_TRS: EBESCT00000103029
EnsemblGenome_PRO: EBESCP00000098889
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P181
eggNOG: COG2990
HOGENOM: HBG468105
OMA: FHASYDE
ProtClustDB: CLSK862866
BioCyc: SSON300269:SSO_P181-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 158608
Gene Ending Position 159558
Gene Strand (Orientation) +
Protein Name required for proper localization of IcsA (VirG) at the surface of bacteria
DNA Sequence 
>gi|74314838:158608-159558 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
TATGTTTTCTGTAAGTAACTTATCATTTATCGGTTTCCTTAAAAGGATTGTTTTTTCCTCAGATTCACTC
CCGGGGAAGTGGGAACACAGAAAATTCCGGTTCATGTACATTTTGCGATGTGCTATAAATCCGGTTGCCA
GTATTCGATATTATTACGAACTGCGTTCCTTGCAGTGCATTGAGGATATTCTGGCAATACAACCCACGTT
GCCAGCAAGAATTCATCGACCTTATTTGCATAAAGGGGGGCGAGCCTGGTCCCGGGGGCAATATATTCTT
GAGCATTATCGCTTTGTGCAAAATTTGCCAGAAAAATATTCTGAATTTTTGTTTCCACAAAAATCGGTAT
CATTAGTCCAATTCATCGGGAAAGATGGAGAGGATTTTGATATCCAGTGTTCTCCCAGTGGTTTTGACCG
GGAAGGAGAGTTGATGTTGTCATTGTTTTTCAATAAAATAGTGATTGCCCGGTTAACATTTTCAGTCATT
CTGACTCAAAATGGACACACCGCTTTTATTGGCGGATTACAGGGAGCCCCCAAAAATACCGGACCTGATG
TTATTCGGTGCGCAACCCGGGCCTGTTATGGGCTTTTCCCAAAACGGATTATTTTTGAAGCATTTTGTGC
GTTGATGAAAGCTTGTAATGTCTCTGAGTGTCTGGCAGTCAGTGAGCACAGTCATGTTTTCCGGCAATTG
AGATACTGGTATCAGAAACGCAAAACCTTTGTTGCTGTCTACAGTGATTTCTGGGAGTCTGTAGCAGGGA
AAACCTGTGGTGACTGGTACAAATTACCAACACAGGTGGTTCGAAAGCCGCTAAGCAATATAGCTAGTAA
AAAACGCTCTGAGTATCGAAAACGATACGCTTTGTTGGATTATATCCATGAAACTGCTATCCGCTCTTTG
GATGCATATCCTGTAAACTCAGAACATCAGGACTTAAATTA
Protein Sequence 
>gi|74315018|ref|YP_313436.1| VirK [Shigella sonnei Ss046] MFSVSNLSFIGFLKRIVFSSDSLPGKWEHRKFRFMYILRCAINPVASIRYYYELRSLQCIEDILAIQPTLPARIHRPYLHKGGRAWSRGQYILEHYRFVQNLPEKYSEFLFPQKSVSLVQFIGKDGEDFDIQCSPSGFDREGELMLSLFFNKIVIARLTFSVILTQNGHTAFIGGLQGAPKNTGPDVIRCATRACYGLFPKRIIFEAFCALMKACNVSECLAVSEHSHVFRQLRYWYQKRKTFVAVYSDFWESVAGKTCGDWYKLPTQVVRKPLSNIASKKRSEYRKRYALLDYIHETAIRSLDAYPVNSEHQDLN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virK mutants have attenuated ability for intracellular spreading in host cells (Wing et al., 2005).
COG COG2990S, under S: Function unknown
References
Wing et al., 2005: Wing HJ, Goldman SR, Ally S, Goldberg MB. Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus. Infection and immunity. 2005; 73(2); 1217-1220. [PubMed: 15664968].