Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

ospG from Shigella sonnei Ss046

Victor ID 1631
Gene Name ospG from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670914
NCBI Protein GI 74315007
Locus Tag SSON_P170
Protein Accession YP_313425.1
Other Database IDs UniProtKB-ID: OSPG_SHISS
UniRef100: UniRef100_Q326Z4
UniRef90: UniRef90_Q326Z4
UniRef50: UniRef50_Q326Z4
UniParc: UPI00000BEF80
EMBL: CP000039
EMBL-CDS: AAZ91190.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000101976
EnsemblGenome_TRS: EBESCT00000102932
EnsemblGenome_PRO: EBESCP00000098792
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P170
eggNOG: NOG151087
HOGENOM: HBG468694
OMA: YSATKND
ProtClustDB: CLSK688138
BioCyc: SSON300269:SSO_P170-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 148829
Gene Ending Position 149419
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|74314838:148829-149419 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
CATGAAAATAACATCTACCATTATTCAAACACCTTTTCCATTTGAGAATAATAATTCTCATGCTGGCATA
GTAACGGAGCCCATTCTCGGTAAGTTAATAGGTCAGGGGTCGACAGCAGAAATCTTTGAAGATGTGAATG
ATTCATCTGCTTTGTATAAAAAGTATGATCTTATTGGCAACCAGTACAATGAGATTCTGGAAATGGCTTG
GCAAGAATCTGAGCTTTTTAATGCTTTTTATGGCGATGAAGCATCCGTTGTTATACAGTATGGCGGAGAT
GTGTACCTCCGAATGCTGCGCGTGCCTGGGACTCCCCTTAGTGACATTGATACAGCTGATATCCCTGATA
ATATAGAGAGCCTTTATCTACAGTTGATATGTAAATTGAATGAGTTGAGTATAATCCATTACGATCTTAA
TACAGGTAATATGCTGTATGATAAAGAAAGTGAAAGTTTATTCCCAATAGATTTTCGCAATATTTATGCT
GAATATTACGCTGCAACCAAAAAAGATAAAGAGATTATCGACCGACGATTACAAATGCGTACAAATGATT
TTTATTCGTTATTAAACAGGAAATATTTATA
Protein Sequence 
>gi|74315007|ref|YP_313425.1| OspG [Shigella sonnei Ss046] MKITSTIIQTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFPIDFRNIYAEYYAATKKDKEIIDRRLQMRTNDFYSLLNRKYL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Upon infection of ileal loops in rabbits, the ospG mutant induced a stronger inflammatory response than the wild-type strain, indicating that OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium (Kim et al., 2005).
COG COG0661R, under R: General function prediction only
References
Kim et al., 2005: Kim DW, Lenzen G, Page AL, Legrain P, Sansonetti PJ, Parsot C. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(39); 14046-14051. [PubMed: 16162672].