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ipaH9.8 from Shigella sonnei Ss046

Victor ID 1630
Gene Name ipaH9.8 from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670911
NCBI Protein GI 74315004
Locus Tag SSON_P167
Protein Accession YP_313422.1
Other Database IDs UniProtKB-ID: IPA9_SHISS
UniRef100: UniRef100_Q3YTH5
UniRef90: UniRef90_B2TT54
UniRef50: UniRef50_Q31SH3
UniParc: UPI00005AAD21
EMBL: CP000039
EMBL-CDS: AAZ91187.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102162
EnsemblGenome_TRS: EBESCT00000103118
EnsemblGenome_PRO: EBESCP00000098978
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P167
eggNOG: COG4886
HOGENOM: HBG673275
OMA: INNSDEL
ProtClustDB: CLSK505000
BioCyc: SSON300269:SSO_P167-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 146463
Gene Ending Position 148100
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|74314838:146463-148100 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
CATGTTACCGATAAATAATAACTTTTCATTGCCCCAAAATTCTTTTTATAACACTATTTCCGGTACATAT
GCTGATTACTTTTCAGCATGGGATAAATGGGAAAAACAAGCGCTCCCCGGTGAAGAGCGTGATGAGGCTG
TCTCCCGACTTAAAGAATGTCTTATCAATAATTCCGATGAACTTCGACTGGACCGTTTAAATCTGTCCTC
GCTACCTGACAACTTACCAGCTCAGATAACGCTGCTCAATGTATCATATAATCAATTAACTAACCTACCT
GAACTGCCTGTTACGCTAAAAAAATTATATTCCGCCAGCAATAAATTATCAGAATTGCCCGTGCTACCTC
CTGCGCTGGAGTCACTTCAGGTACAACACAATGAGCTGGAAAACCTGCCAGCTTTACCCGATTCGTTATT
GACTATGAATATCAGCTATAACGAAATAGTCTCCTTACCATCGCTCCCACAGGCTCTTAAAAATCTCAGA
GCGACCCGTAATTTCCTCACTGAGCTACCAGCATTTTCTGAGGGAAATAATCCCGTTGTCAGAGAGTATT
TTTTTGATAGAAATCAGATAAGTCATATCCCGGAAAGCATTCTTAATCTGAGGAATGAATGTTCAATACA
TATTAGTGATAACCCATTATCATCCCATGCTCTGCAAGCCCTGCAAAGATTAACCTCTTCGCCGGACTAC
CACGGCCCACGGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATG
CCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGA
AGAGCATGCCAACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCC
GGATTCCGTGAACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTT
TCGCTGTTGCTGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAA
AACCCTCCTGGTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGC
AGGGAAATGTTCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGG
ATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAA
GGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGA
AGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTA
CGGAAGCTGACCGCTGGGCGCAGGCAGAAGAGCAGAAGTATGAGATGCTGGAGAATGAGTACTCTCAGAG
GGTGGCTGACCGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAG
GTGATGCGTGAGACTGAACAGCAGATTTACCGTCAGCTGACTGACGAGGTACTGGCCCTGCGATTGTCTG
AAAACGGCTCACAACTGCACCATTCATA
Protein Sequence 
>gi|74315004|ref|YP_313422.1| invasion plasmid antigen [Shigella sonnei Ss046] MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALQALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH9.8 deletion mutant caused more severe inflammatory responses with increased pro-inflammatory cytokine production levels than did wild-type Shigella, which resulted in a 30-fold decrease in bacterial colonization in murine lungs (Okuda et al., 2005).
COG COG4886S, under S: Function unknown
References
Okuda et al., 2005: Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C. Shigella effector IpaH9.8 binds to a splicing factor U2AF(35) to modulate host immune responses. Biochemical and biophysical research communications. 2005; 333(2); 531-539. [PubMed: 15950937].