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virA from Shigella sonnei Ss046

Victor ID 1629
Gene Name virA from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670886
NCBI Protein GI 74314979
Locus Tag SSON_P142
Protein Accession YP_313397.1
Other Database IDs UniProtKB-ID: VIRA_SHISS
UniRef100: UniRef100_Q3YTK0
UniRef90: UniRef90_Q326N4
UniRef50: UniRef50_Q3YTK0
UniParc: UPI00005AAD12
EMBL: CP000039
EMBL-CDS: AAZ91162.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102020
EnsemblGenome_TRS: EBESCT00000102976
EnsemblGenome_PRO: EBESCP00000098836
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P142
HOGENOM: HBG683626
OMA: AHANIDG
ProtClustDB: CLSK505080
BioCyc: SSON300269:SSO_P142-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 124334
Gene Ending Position 125536
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|74314838:124334-125536 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
CTTAAACATCAGGAGATATGATGGCAAATGATACTTGACGACTTTCTGGAGGGATAGCATTGCGAAGCCC
TTCACTGCTTGGAAGTGTTCCAGCATGAACGAGATAGCTTGTTTCTATTTTATTAATACCAACACCATTA
CATGTTATGTGCGATGGTAATATTGATGAGCTAACTTCGTAAGCCCTCCCCCCAGAGGCAGAGATTGCAG
TGTCGTTTTTAGGGACAACTGCGTTGATTTTTATAATATGTCCACAATTGTTAATAACTCGTTGTTCAGG
CATGAAATTAAGCCTGTTTTCTATGTTTTCGGACATAATTTGGGCATATATGTGTTCCACAGAGGAAGAC
GTGATGTGAAGAGATTGCCAGAATGCAGATGTTAGTGCAGATATAAATGCAGGGTCTTGAAAGAGTGAAG
TAAACAAAAGTTTTTCTGTTTGAAAACATAGGTCTTGTTGGGGGAAGTTTGAATTGATTATTTTATTTAC
TTGGTTGTAACTTAGCATTTGAAGCTCTTTTTTGCTATCAATGAATTCATTAATTCCTAACTCATTAATT
AGATCTGCAATTAATTTTAGTGGTATTTCAATATTGTTGAAATATATTTTTGTACTATTGCTGTTAGATG
CTCTAATATCTCTGTAAATATCATGCCAAACACTATTAAAATCAGTGTCTTTAACGGGGAAGTAATCATC
GTTTGGTATTATCGATGTACAGCAATTAATGGCTGTTTCAATAACTTCTGGTGCAGGCTTGTGAGTTTTA
AAATTCCCTGATACCGGAGCTGTAATAGTATGTACTTTTCCTAAGTTGAATTGTTTGGGGGGGAGTGAAC
TTAACAAGTTATTATATTCTTTTGATGAAAGTTGAGTGGATTGTATTTTATCTCCATCAAGATAAAAAAC
CGAACATATGCCTTTGTTAAGGCATAGCCGTATTGAAATGCCATCTATGTTTGCGTGGGCAAACTCTCCG
TCCATTTTATCTTGTGATAGTGATGGTGAGAAACTATCCATTAGTTTTTTTTCGCTATATTTTTCGGCTA
GAGTTTCGTGTGGAGAATATATGCCGAAAGTTATTATTTTCAGTAAAACGTCACAAAAACTCAATTTATT
CCAACTTACTTCTGTAGTTGATTTGACAGTTGACATCCATGATGAGTCATTTCTTTCATGGTTAGTTATG
TTTGATGTCTGCA
Protein Sequence 
>gi|74314979|ref|YP_313397.1| VirA [Shigella sonnei Ss046] MQTSNITNHERNDSSWMSTVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKGICSVFYLDGDKIQSTQLSSKEYNNLLSSLPPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFPVKDTDFNSVWHDIYRDIRASNSNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQMLSYNQVNKIINSNFPQQDLCFQTEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPEQRVINNCGHIIKINAVVPKNDTAISASGGRAYEVSSSILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPESRQVSFAIISPDV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virA mutants did not move within the host cytoplasm and failed to move into adjacent cells (Yoshida et al., 2006).
References
Yoshida et al., 2006: Yoshida S, Handa Y, Suzuki T, Ogawa M, Suzuki M, Tamai A, Abe A, Katayama E, Sasakawa C. Microtubule-severing activity of Shigella is pivotal for intercellular spreading. Science (New York, N.Y.). 2006; 314(5801); 985-989. [PubMed: 17095701].