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mxiA from Shigella sonnei Ss046

Victor ID 1624
Gene Name mxiA from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670853
NCBI Protein GI 74314946
Locus Tag SSON_P109
Protein Accession YP_313364.1
Other Database IDs UniProtKB-ID: Q3YTN3_SHISS
UniRef100: UniRef100_Q3YTN3
UniRef90: UniRef90_P0A1I5
UniRef50: UniRef50_P0A1I5
UniParc: UPI0000170282
EMBL: CP000039
EMBL-CDS: AAZ91129.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102158.
EnsemblGenome_TRS: EBESCT00000103114
EnsemblGenome_PRO: EBESCP00000098974
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P109
eggNOG: COG4789
HOGENOM: HBG595253
OMA: GRNIMSQ
ProtClustDB: CLSK862855
BioCyc: SSON300269:SSO_P109-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 99963
Gene Ending Position 102029
Gene Strand (Orientation) +
Protein Name innermembrane protein; component of the Mxi-Spa secretion machinery
DNA Sequence 
>gi|74314838:99963-102029 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
GATGAAAGTGATCCAGTCTTTTCTTAAGCAAGTAAGTACTAAGCCTGAATTAATTATATTAGTGCTTATG
GTTATGATCATTGCTATGTTGATCATACCATTACCTACATACCTTGTTGATTTTTTAATAGGGCTTAATA
TTGTACTTGCTATTCTCGTTTTTATGGGATCATTTTATATTGAAAGAATATTGAGTTTTTCTACATTCCC
TTCGGTTTTGTTGATAACGACATTATTTCGTCTCGCTTTATCAATAAGTACTAGTCGACTAATTTTAGTT
GATGCGGATGCGGGTAAAATTATTACTACATTTGGCCAGTTTGTCATTGGTGATAGTCTGGCTGTAGGTT
TTGTTATTTTTTCAATAGTAACTGTTGTGCAGTTCATTGTTATAACAAAAGGATCTGAAAGGGTTGCGGA
GGTAGCTGCTCGCTTTTCTCTTGACGGTATGCCGGGGAAACAAATGAGCATTGATGCGGATTTAAAGGCT
GGAATTATTGATGCCGCAGGAGCTAAAGAAAGACGCAGTATTCTGGAACGTGAGAGTCAATTGTATGGTT
CATTTGATGGAGCAATGAAGTTCATTAAAGGTGATGCAATTGCTGGCATCATTATTATTTTTGTCAATTT
AATAGGAGGTATTTCTGTTGGTATGAGTCAACATGGAATGTCCCTATCTGGTGCATTATCTACTTATACC
ATACTAACTATTGGTGACGGATTGGTCTCTCAGATTCCTGCTCTGTTAATTTCTATAAGTGCAGGATTTA
TCGTTACAAGAGTTAATGGTGATAGCGATAATATGGGACGTAACATAATGTCCCAGATATTTGGGAATCC
TTTTGTTCTCATTGTTACATCAGCTCTTGCCTTGGCGATAGGGATGTTGCCAGGTTTTCCGTTTTTTGTT
TTTTTCCTGATAGCAGTTACTTTGACGGCTTTATTCTATTATAAAAAGGTCGTAGAAAAAGAAAAAAGTC
TGTCTGAGTCTGATTCTAGTGGCTATACTGGTACATTTGATATTGATAATAGCCATGACTCATCTTTGGC
AATGATAGAAAATCTGGATGCTATTAGTTCAGAAACCGTTCCTTTAATTTTATTATTTGCCGAAAATAAG
ATAAATGCAAATGATATGGAAGGTCTTATTGAAAGGATAAGAAGTCAGTTCTTTATTGATTATGGTGTCA
GGCTTCCAACTATTTTATATAGAACAAGCAATGAGCTTAAGGTCGATGATATTGTTTTGTTAATAAATGA
GGTGCGTGCCGATAGTTTTAATATATATTTTGACAAAGTGTGTATTACAGATGAAAATGGAGATATAGAT
GCTCTAGGTATTCCTGTTGTTTCAACTTCATATAATGAACGTGTTATTTCTTGGGTAGACGTTTCATATA
CAGAAAATCTAACTAATATTGATGCTAAAATTAAAAGTGCTCAAGATGAATTTTATCACCAGTTGTCACA
AGCTTTATTAAACAACATAAATGAGATTTTTGGTATACAAGAAACAAAAAATATGTTAGATCAGTTTGAA
AATCGGTATCCTGATCTATTAAAGGAAGTCTTCCGACATGTGACTATACAGAGAATTTCTGAGGTATTAC
AAAGATTGCTTGGAGAAAATATTTCTGTTCGCAATTTAAAACTTATTATGGAGTCTTTGGCGCTTTGGGC
TCCCAGAGAAAAAGATGTCATAACATTAGTTGAACATGTCCGTGCATCACTTTCTAGGTATATTTGTAGT
AAAATAGCTGTTTCTGGTGAGATTAAAGTTGTGATGCTTTCCGGATATATTGAGGATGCAATAAGAAAAG
GGATAAGGCAAACCTCTGGTGGCTCTTTCTTGAATATGGATATAGAGGTTTCGGATGAGGTAATGGAAAC
TTTAGCACATGCTTTGAGAGAATTGAGAAATGCAAAAAAAAATTTCGTTCTTTTGGTATCAGTAGATATA
CGTAGGTTTGTTAAAAGACTTATAGATAACAGATTTAAGAGTATACTCGTTATATCGTATGCTGAGATTG
ATGAAGCATATACCATTAATGTATTAAAGACTATTTA
Protein Sequence 
>gi|74314946|ref|YP_313364.1| MxiA [Shigella sonnei Ss046] MKVIQSFLKQVSTKPELIILVLMVMIIAMLIIPLPTYLVDFLIGLNIVLAILVFMGSFYIERILSFSTFPSVLLITTLFRLALSISTSRLILVDADAGKIITTFGQFVIGDSLAVGFVIFSIVTVVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLKAGIIDAAGAKERRSILERESQLYGSFDGAMKFIKGDAIAGIIIIFVNLIGGISVGMSQHGMSLSGALSTYTILTIGDGLVSQIPALLISISAGFIVTRVNGDSDNMGRNIMSQIFGNPFVLIVTSALALAIGMLPGFPFFVFFLIAVTLTALFYYKKVVEKEKSLSESDSSGYTGTFDIDNSHDSSLAMIENLDAISSETVPLILLFAENKINANDMEGLIERIRSQFFIDYGVRLPTILYRTSNELKVDDIVLLINEVRADSFNIYFDKVCITDENGDIDALGIPVVSTSYNERVISWVDVSYTENLTNIDAKIKSAQDEFYHQLSQALLNNINEIFGIQETKNMLDQFENRYPDLLKEVFRHVTIQRISEVLQRLLGENISVRNLKLIMESLALWAPREKDVITLVEHVRASLSRYICSKIAVSGEIKVVMLSGYIEDAIRKGIRQTSGGSFLNMDIEVSDEVMETLAHALRELRNAKKNFVLLVSVDIRRFVKRLIDNRFKSILVISYAEIDEAYTINVLKTI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiA mutants were attenuated in invasion of HeLa cells (Andrews et al., 1991).
COG COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport
References
Andrews et al., 1991: Andrews GP, Hromockyj AE, Coker C, Maurelli AT. Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens. Infection and immunity. 1991; 59(6); 1997-2005. [PubMed: 2037361].