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mxiC from Shigella sonnei Ss046

Victor ID 1623
Gene Name mxiC from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670852
NCBI Protein GI 74314945
Locus Tag SSON_P108
Protein Accession YP_313363.1
Other Database IDs UniProtKB-ID: Q3YTN4_SHISS
UniRef100: UniRef100_Q939L4
UniRef90: UniRef90_Q04640
UniRef50: UniRef50_Q04640
UniParc: UPI00000B6504
EMBL: CP000039
EMBL-CDS: AAZ91128.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102125.
EnsemblGenome_TRS: EBESCT00000103081
EnsemblGenome_PRO: EBESCP00000098941
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P108
eggNOG: NOG04987
HOGENOM: HBG683617
OMA: SRASHED
ProtClustDB: CLSK505058
BioCyc: SSON300269:SSO_P108-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 98889
Gene Ending Position 99956
Gene Strand (Orientation) +
Protein Name secreted by and putative component of the Mxi-Spa secretion machinery; similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica)
DNA Sequence 
>gi|74314838:98889-99956 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
TATGCTTGATGTTAAAAATACAGGAGTTTTTAGCTCTGCATTCATTGATAAGTTGAATGCAATGACAAAT
TCAGATGATGGAGATGAGACTGCTGATGCAGAGCTTGATTCTGGCTTGGCTAATAGCAAGTATATTGACT
CATCTGATGAGATGGCTTCCGCTCTTTCGTCATTTATAAACAGAAGAGACCTTGAGAAACTGAAAGGAAC
AAATAGTGATAGTCAGGAACGTATTTTAGATGGGGAAGAAGATGAAATTAATCACAAGATTTTTGATTTA
AAGAGAACGTTAAAAGATAACCTTCCTCTAGATCGGGATTTTATAGACAGACTAAAGAGATATTTTAAAG
ATCCAAGTGATCAAGTCTTAGCATTAAGGGAACTTTTGAATGAAAAAGATCTTACTGCTGAACAAGTCGA
ATCATTAACTAAAATTATTAATGAGATAATATCAGGTAGTGAAAAAAGTGTTAATGCTGGAATAAATTCA
GCTATACAGGCTAAATTATTTGGCAACAAAATGAAACTTGAACCACAGCTTTTGCGTGCATGTTATCGTG
GTTTTATCATGGGGAACATATCAACAACAGATCAGTATATAGAATGGCTTGGTAATTTTGGTTTTAATCA
CAGACATACAATTGTGAATTTTGTAGAGCAGTCACTGATTGTAGACATGGATTCTGAGAAACCGAGCTGT
AATGCTTATGAGTTTGGTTTTGTGTTATCTAAATTAATTGCAATTAAGATGATTAGAACTTCAGACGTAA
TTTTTATGAAGAAACTGGAATCCTCAAGCTTGCTAAAAGATGGCAGTTTAAGTGCAGAGCAGCTATTGCT
AACTTTATTATATATTTTTCAATATCCAAGTGAAAGTGAGCAAATTCTTACTTCTGTTATAGAAGTATCA
CGAGCCAGTCATGAGGATTCTGTAGTGTATCAAACATATCTATCTTCTGTTAATGAAAGTCCTCATGATA
TATTTAAAAGTGAAAGTGAAAGAGAAATTGCGATCAATATTCTACGAGAGCTTGTCACAAGTGCATACAA
GAAAGAGCTTTCTAGATA
Protein Sequence 
>gi|74314945|ref|YP_313363.1| MxiC [Shigella sonnei Ss046] MLDVKNTGVFSSAFIDKLNAMTNSDDGDETADAELDSGLANSKYIDSSDEMASALSSFINRRDLEKLKGTNSDSQERILDGEEDEINHKIFDLKRTLKDNLPLDRDFIDRLKRYFKDPSDQVLALRELLNEKDLTAEQVESLTKIINEIISGSEKSVNAGINSAIQAKLFGNKMKLEPQLLRACYRGFIMGNISTTDQYIEWLGNFGFNHRHTIVNFVEQSLIVDMDSEKPSCNAYEFGFVLSKLIAIKMIRTSDVIFMKKLESSSLLKDGSLSAEQLLLTLLYIFQYPSESEQILTSVIEVSRASHEDSVVYQTYLSSVNESPHDIFKSESEREIAINILRELVTSAYKKELSR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiC mutant has a 10-fold decrease in efficiency in invading epithelial cells (Botteaux et al., 2009).
References
Botteaux et al., 2009: Botteaux A, Sory MP, Biskri L, Parsot C, Allaoui A. MxiC is secreted by and controls the substrate specificity of the Shigella flexneri type III secretion apparatus. Molecular microbiology. 2009; 71(2); 449-460. [PubMed: 19017268].