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mxiG from Shigella sonnei Ss046

Victor ID 1614
Gene Name mxiG from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670842
NCBI Protein GI 74314935
Locus Tag SSON_P098
Protein Accession YP_313353.1
Other Database IDs UniProtKB-ID: Q3YTP4_SHISS
UniRef100: UniRef100_P0A221
UniRef90: UniRef90_P0A221
UniRef50: UniRef50_P0A221
UniParc: UPI000012FAAF
EMBL: CP000039
EMBL-CDS: AAZ91118.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000101992.
EnsemblGenome_TRS: EBESCT00000102948
EnsemblGenome_PRO: EBESCP00000098808
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P098
eggNOG: NOG13450
HOGENOM: HBG683613
OMA: FPYINLY
ProtClustDB: CLSK688132
BioCyc: SSON300269:SSO_P098-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 92037
Gene Ending Position 93152
Gene Strand (Orientation) +
Protein Name component of the Mxi-Spa secretion machinery, contains one transmembrane segment
DNA Sequence 
>gi|74314838:92037-93152 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
TATGTCTGAGGCAAAGAACTCAAATCTTGCACCATTCAGGTTATTAGTGAAACTCACAAACGGTGTCGGG
GATGAGTTTCCGTTATATTATGGGAATAACTTAATTGTTCTCGGACGGACGATAGAAACACTTGAGTTTG
GAAACGACAATTTCCCAGAAAATATTATTCCTGTAACAGATAGTAAATCGGATGGTATAATTTATTTGAC
CATAAGCAAAGATAATATCTGTCAATTTAGTGATGAAAAAGGTGAGCAAATTGATATCAATTCACAATTT
AATTCATTTGAATATGACGGGATTTCTTTTCACCTTAAAAATATGAGGGAGGATAAATCGAGAGGCCATA
TACTAAACGGAATGTATAAGAACCACTCGGTGTTTTTTTTCTTTGCTGTTATTGTTGTGTTAATTATAAT
TTTTTCCCTCTCTTTAAAGAAAGATGAAGTAAAAGAAATTGCTGAAATTATAGATGATAAGAGATATGGA
ATAGTCAACACTGGACAGTGCAATTATATTCTTGCCGAAACACAAAATGATGCGGTATGGGCATCTGTAG
CTTTAAATAAAACCGGATTTACCAAATGCAGATATATTCTGGTGTCAAACAAAGAAATAAATAGAATTCA
ACAATATATCAATCAACGATTCCCATTTATCAATTTGTATGTGTTGAATTTAGTGAGTGATAAAGCGGAA
TTACTGGTGTTTTTAAGTAAAGAAAGAAATAGTTCAAAAGATACCGAACTTGATAAATTGAAAAATGCTC
TGATTGTTGAATTTCCGTATATCAAAAATATTAAATTCAACTATCTTAGCGATCATAATGCAAGGGGGGA
TGCTAAAGGTATTTTCACAAAGGTAAATGTCCAGTATAAAGAGATTTGTGAAAATAATAAAGTTACATAT
TCTGTCAGAGAAGAACTGACAGATGAAAAGCTTGAGCTCATTAATAGACTGATTTCTGAACATAAAAATA
TATATGGAGATCAGTATATTGAGTTTTCTGTACTTTTGATAGATGATGATTTTAAAGGTAAATCATATCT
TAACAGCAAAGACAGTTATGTAATGTTGAATGATAAACACTGGTTTTTTTTAGATAAAAATAAGTG
Protein Sequence 
>gi|74314935|ref|YP_313353.1| MxiG [Shigella sonnei Ss046] MSEAKNSNLAPFRLLVKLTNGVGDEFPLYYGNNLIVLGRTIETLEFGNDNFPENIIPVTDSKSDGIIYLTISKDNICQFSDEKGEQIDINSQFNSFEYDGISFHLKNMREDKSRGHILNGMYKNHSVFFFFAVIVVLIIIFSLSLKKDEVKEIAEIIDDKRYGIVNTGQCNYILAETQNDAVWASVALNKTGFTKCRYILVSNKEINRIQQYINQRFPFINLYVLNLVSDKAELLVFLSKERNSSKDTELDKLKNALIVEFPYIKNIKFNYLSDHNARGDAKGIFTKVNVQYKEICENNKVTYSVREELTDEKLELINRLISEHKNIYGDQYIEFSVLLIDDDFKGKSYLNSKDSYVMLNDKHWFFLDKNK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiG mutant was unable to enter HeLa cells and to provoke keratoconjunctivitis in guinea-pigs (Allaoui et al., 1995).
References
Allaoui et al., 1995: Allaoui A, Sansonetti PJ, Ménard R, Barzu S, Mounier J, Phalipon A, Parsot C. MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination. Molecular microbiology. 1995; 17(3); 461-470. [PubMed: 8559065].