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ipgD from Shigella sonnei Ss046

Victor ID 1613
Gene Name ipgD from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670839
NCBI Protein GI 74314932
Locus Tag SSON_P095
Protein Accession YP_313350.1
Other Database IDs UniProtKB-ID: Q3YTP7_SHISS
UniRef100: UniRef100_Q55286
UniRef90: UniRef90_Q07566
UniRef50: UniRef50_Q07566
UniParc: UPI000012D7E0
EMBL: CP000039
EMBL-CDS: AAZ91115.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102070.
EnsemblGenome_TRS: EBESCT00000103026
EnsemblGenome_PRO: EBESCP00000098886
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P095
eggNOG: NOG29401
HOGENOM: HBG671713
OMA: NSSERAV
ProtClustDB: CLSK862850
BioCyc: SSON300269:SSO_P095-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 89582
Gene Ending Position 91198
Gene Strand (Orientation) +
Protein Name secreted by the Mxi-Spa machinery; modulates entry of bacteria into epithelial cells
DNA Sequence 
>gi|74314838:89582-91198 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
AATGCACATAACTAATTTGGGATTGCATCAGGTTTCATTTCAAAGCGGAGATTCCTATAAAGGCGCAGAA
GAAACCGGAAAGCACAAAGGTGTAAGCGTGATTTCATATCAAAGAGTTAAAAATGGAGAAAGAAATAAGG
GGATCGAAGCGCTTAATCGATTATATTTACAGAACCAAACAAGCTTAACAGGAAAAAGCCTTTTGTTTGC
GCGTGACAGAGCTGAAGTTTTTTACGAGGCAATAAAGTTGGCAGGTGGTGATACGTCAAAAATTAAAGCC
ATGATGGAACGATTAGATACCTATAAACTTGGTGAAGTTAATAAAAGACATATTAATGAGCTTAATAAAG
TAATAAGTGAAGAGATAAGAGCACAGCTAGGCATTAAAAATAAAAAGGAATTGCAAACGAAAATAAAACA
AATATTTACTGATTATTTAAATAATAAGAATTGGGGACCGGTCAACAAGAATATTAGTCATCATGGGAAA
AATTATGGTTTTCAATTAACACCTGCCTCTCATATGAAGATAGGGAATAAAAATATATTTGTCAAAGAGT
ATAATGGAAAAGGAATTTGTTGTGCTTCTACGAGAGAGAGTGATCATATCGCGAATATGTGGCTTTCAAA
AGTGGTGGATGACGAGGGGAAGGAAATTTTTTCGGGTATCAGACATGGAGTTATATCAGCCTATGGATTG
AAAAAAAACTCATCTGAAAGAGCTGTTGCTGCTCGTAATAAAGCTGAGGAGTTAGTAAGCGCAGCATTAT
ATAGCAGACCAGAGTTATTATCACAGGCTTTGTCTGGTAAAACAGTAGATTTAAAGATTGTTTCGACTTC
TCTTCTGACGCCGACCAGTTTAACCGGGGGAGAGGAGAGTATGTTAAAAGATCAGGTGAACGCATTAAAA
GGGTTAAACTCTAAAAGGGGGGAGCCAACGAAATTATTAATTCGGAATAGTGATGGTCTTCTGAAAGAAG
TAAGCGTTAATCTAAAAGTGGTGACATTTAACTTTGGTGTAAATGAATTAGCGCTAAAAATGGGCTTAGG
CTGGAGGAATGTTGACAAGCTTAATGATGAATCAATATGTTCTTTGTTGGGGGATAATTTCCTCAAAAAT
GGTGTGATTGGAGGTTGGGCTGCAGAAGCAATAGAAAAAAATCCACCATGTAAGAATGATGTGATATATC
TGGCTAACCAGATAAAAGAGATTATAAACAAGAAGTTACAAAAAAATGATAATGGAGAGCCGTATAAATT
GTCACAAAGAATGACTCTATTGGCTTATACTATAGGTGCTGTACCTTGCTGGAATTGTAAGAGTGGGAAG
GACAGAACAGGTATGCAGGATGCTGAAATTAAAAGAGAAATAATAAGAAAACATGAAACAGGTCAGTTTT
CTCAATTAAATAGTAAATTATCCTCAGAAGAGAAAAGATTATTTTCTACTATTCTAATGAATAGTGGTAA
TATGGAAATCCAAGAGATGAATACTGGTGTGCCCGGAAATAAAGTCATGAAAAAATTGCCGCTATCTTCG
TTAGAGCTATCTTATTCTGAAAGAATAGGGGACTCAAAAATATGGAATATGGTGAAAGGGTATTCGTCAT
TTGTATA
Protein Sequence 
>gi|74314932|ref|YP_313350.1| IpgD [Shigella sonnei Ss046] MHITNLGLHQVSFQSGDSYKGAEETGKHKGVSVISYQRVKNGERNKGIEALNRLYLQNQTSLTGKSLLFARDRAEVFYEAIKLAGGDTSKIKAMMERLDTYKLGEVNKRHINELNKVISEEIRAQLGIKNKKELQTKIKQIFTDYLNNKNWGPVNKNISHHGKNYGFQLTPASHMKIGNKNIFVKEYNGKGICCASTRESDHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELVSAALYSRPELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVNALKGLNSKRGEPTKLLIRNSDGLLKEVSVNLKVVTFNFGVNELALKMGLGWRNVDKLNDESICSLLGDNFLKNGVIGGWAAEAIEKNPPCKNDVIYLANQIKEIINKKLQKNDNGEPYKLSQRMTLLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYSERIGDSKIWNMVKGYSSFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipgD mutant is unable to dephosphorylate phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] and induces shorter filapodia in host cells (Niebuhr et al., 2002).
References
Niebuhr et al., 2002: Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B. Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. The EMBO journal. 2002; 21(19); 5069-5078. [PubMed: 12356723].