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ipaB from Shigella sonnei Ss046

Victor ID 1608
Gene Name ipaB from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670834
NCBI Protein GI 74314927
Locus Tag SSON_P090
Protein Accession YP_313345.1
Other Database IDs UniProtKB-ID: Q3YTQ2_SHISS
UniRef100: UniRef100_Q3YTQ2
UniRef90: UniRef90_Q03945
UniRef50: UniRef50_P18011
UniParc: UPI00005AACFD
EMBL: CP000039
EMBL-CDS: AAZ91110.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102079.
EnsemblGenome_TRS: EBESCT00000103035
EnsemblGenome_PRO: EBESCP00000098895
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P090
eggNOG: NOG04838
HOGENOM: HBG673809
OMA: NTIQAAN
ProtClustDB: CLSK862848
BioCyc: SSON300269:SSO_P090-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 84467
Gene Ending Position 86209
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery; required for entry into epithelial cells
DNA Sequence 
>gi|74314838:84467-86209 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
ATCAAGCAGTAGTTTGTTGCAAAATTGCTTTTGCAACATCAGTTCTATTAGCCTGAGAGTTGGACATTGA
GGCTAATAGATCTGCAATTACTTCCTGCAATTGGCCGAATTTTTCTATTGCTTCACTGATATATTTTGAC
AGTTGTTCAACTTGATATTTCGATAATGTCAGGTCTGCTAGATTTGTAGACGCGCTGTTCTGGAAAACAG
CAGAAGCGACACTTCCTCCCGCTTGTGTGGCAGAGTTAACACTTTCTCCTAATAAAACTGCTTGGTTTAA
ATGGGTGGAAATAATTTGTTTGGATATTACTTCATCACCCGCTGCACCAAGAAATTTATTTAATCTGGCA
ACAGCATTAGTGATTAAATCGTCCAGTTGAGAAGAAAAATTCTTGAGAAACTTTGGTATAAGGTCTGTGA
GGGTTTTACCTATTATTTTGCCAATATTCTCTGCAAGTTTTGCTGCTGCCTGTTTACCAACAGTGGCTAC
GAGAACTACTGCTGCAACCAGGACAAGAGCGCCTGCGATTGCCCCCAGAATAGAGCCAATCATTTTGGCT
TTTTTCGAGTCGACGCCCAAGCCTTCGAGCATTTTTGTAAATGCATCTGAAAGGAGTTTGATTAAGGGTT
CAATGACTGCTTTCATGATCGGATTCAGGGCTTGTTCCATGAAGGAATTGCCGGTCGCTGCTTGTACTAT
AGCATCCGTAACCATAAGAGCTAAACCAACAGCTGCCAGTGCTAGAGAGGCTCCTCCAGAAAAAGCTGCT
GCAACAACACTAACGATAGTTAAAAGTGCCCCAAGTATTTTCCCAACACAACCCATTACTCTGTTGAGTT
CTTCTGCTTTACGTACTTCAGCAGCATACTCATCAGATTTTCTCTCCATTTCAGTTTTTCTTGATTCTTG
GAGAGACTGGAATAGAGCCAGATCATTTTTTAAAGATTCTTCATTATTTTTTCCAACTAGTTGAATAAAG
GTTGCCATCAATTGAGTAACACTGGCAAGTCCGGTTAATGATTTCTGCTGGGTTGATAGCTGTTCAGCAG
ATGCTGTGTTTGAAAATGCAGAAAAAGAGTCTATTTCTTTTTCGAGTTGCATTGATTTATCTGTAAGTTT
GCTATGAATTGACAGGGTTTTCTGCTCAATCAATGTCCTGTCTTTAACTGCTGCGTCTTTTTTGATAGTG
AGTTGTATTTCTTCCCGGCTTAATTTTTTCTTTTCTGGTGAATCTGGGTCGAGTTCGGATAATCTTGTTT
GAATTTGGTTAATTTTATTTTCTAGGTCTTTTATTTTAGAATCTGCGTTTTTTAGTTTATTAATTTGTTT
TTCATAGTCTCTGGTTAGTCCTTCAGTTTCAGATAGAAGAGTATTAATTTTATCGGAGAATTCTAGGTTT
TTTTGCTGTCTTGCCTGTTGCTGAGACTTCCAAGCAGTAATTTTATTTGTTAATGCAGTTAAAGATTTTT
CACCGAGTATTTGAATAAGGTTTCCAATTAAAAGCGTTAGTTGGGAACTTGCATTTAATGACTTTGGTGC
TTTAAGTTCAGGGATTAATATATTTGAAGTTGAGTGTGAATTAGTTGTATTAATATTTTTGTTAGCAGTA
AGATCAGCAATTGTAAGAGAAAATAATTTGTTAGCTGCATCATTTGCAGCCTGGATAGTATTGTCTCCAA
GCTCAGTGGAAGCCAATATTTTGGCAAGAGACAAACCAGTGGTTGTGGTACTTACATTATGCA
Protein Sequence 
>gi|74314927|ref|YP_313345.1| IpaB [Shigella sonnei Ss046] MHNVSTTTTGLSLAKILASTELGDNTIQAANDAANKLFSLTIADLTANKNINTTNSHSTSNILIPELKAPKSLNASSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSETEGLTRDYEKQINKLKNADSKIKDLENKINQIQTRLSELDPDSPEKKKLSREEIQLTIKKDAAVKDRTLIEQKTLSIHSKLTDKSMQLEKEIDSFSAFSNTASAEQLSTQQKSLTGLASVTQLMATFIQLVGKNNEESLKNDLALFQSLQESRKTEMERKSDEYAAEVRKAEELNRVMGCVGKILGALLTIVSVVAAAFSGGASLALAAVGLALMVTDAIVQAATGNSFMEQALNPIMKAVIEPLIKLLSDAFTKMLEGLGVDSKKAKMIGSILGAIAGALVLVAAVVLVATVGKQAAAKLAENIGKIIGKTLTDLIPKFLKNFSSQLDDLITNAVARLNKFLGAAGDEVISKQIISTHLNQAVLLGESVNSATQAGGSVASAVFQNSASTNLADLTLSKYQVEQLSKYISEAIEKFGQLQEVIADLLASMSNSQANRTDVAKAILQQTTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaB mutant is unable to infect HeLa cells (Roehrich et al., 2010).
COG COG2433S, under S: Function unknown
References
Roehrich et al., 2010: Roehrich AD, Martinez-Argudo I, Johnson S, Blocker AJ, Veenendaal AK. The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding. Infection and immunity. 2010; 78(4); 1682-1691. [PubMed: 20086081].