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ipaC from Shigella sonnei Ss046

Victor ID 1607
Gene Name ipaC from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670833
NCBI Protein GI 74314926
Locus Tag SSON_P089
Protein Accession YP_313344.1
Other Database IDs UniProtKB-ID: Q3YTQ3_SHISS
UniRef100: UniRef100_Q3YTQ3
UniRef90: UniRef90_Q03946
UniRef50: UniRef50_P18012
UniParc: UPI00005AACFC
EMBL: CP000039
EMBL-CDS: AAZ91109.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102072.
EnsemblGenome_TRS: EBESCT00000103028
EnsemblGenome_PRO: EBESCP00000098888
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P089
eggNOG: NOG25967
HOGENOM: HBG683609
OMA: ISQASSK
ProtClustDB: CLSK862847
BioCyc: SSON300269:SSO_P089-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 83356
Gene Ending Position 84447
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery; required for entry into epithelial cells
DNA Sequence 
>gi|74314838:83356-84447 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
ATTAAGCTCGAATGTTACCAGCAATCTGACTGGCTGTCGAATTCCTTGATTGGGTGATGCTGTCAATTAT
ATTCAATAATTTTTGTATTAATTGATTTGTCGCTTGGGATGCTTCTTTAGATACTTGGGATGCTTCCTCT
GCTTGTTTACTGCTGGCCTGACTGATTAGTTGTTCTTCTTCTTCAAGAGCAGATGCATAACGCCCTCCTG
ATGTGGATATATTACCAGCAACGGCTGATGTGTCCATTGTTGCACGGCCAATATTTTGTTTTTGCTGCGC
AGAAAGGGTATTGAGCTCGTAAGTTCTTCTCTGGGTGTCAATTTTATCCTGCAAAGAAATATCGGGAGAA
CTAAGAGAAGTTTTATGTTCAGTTGACAGGGATATATTATCTGGCGCCAGTTTATTTTTACCTAAAAATT
TTGTGCTAGAGTTAGTTTGTGGTGAGGTGATATTTGTATCTATTTGTTTATTTAACCCTAATTTAGAACC
TGCAAGCTCTTTTTCAAGAGATTGAGCAGTGGCAAGGTTCTTTCTTAAGGCTCCTTTTTGGTCGCTAATC
CCTGAATGCGTTTTTTTGGCACCGATACCCGTTATACCTACTTGTGTGACTGCTCCAGTAATGCTTGATG
ATAGGGCTGCCAGGCCTTGCCGAACAATGTTCTCTGCAGCTGATTTTGTAGCATCGAACGCAATCAATGA
CAATTGAGAGCCCAATTTAGTTTCTGCAGTGCGGAGAGCAGAAAGTAGAACGGCTACACTAATAATTAAA
GAAACAGCATTAGAAGAAAGACTGGAAATATCCAGAGTGTTCTCTGGAGTAAGGGTGTGACTCATCTCTG
AAAGATCTTTCATCTTTTTGTCAGTAAGGCGAGCAATGATTTCTGAATCATGCTGAACCTGCTCTGATAA
CTTTAAAAGTTGATCATCATTTAATGTGGTTGTTAATACGGGATTTTTACCGACATTAAGTGGAATATGC
GCTGCAATCTGCTGATAATTTTGTGATTTTTGTGTTTCGGAAGAACTTTGAGTTTGTTTTGTGGATATAT
CTGTATATAAAATCTGGGTTGATTTTGTGTTTTGAATTTCCA
Protein Sequence 
>gi|74314926|ref|YP_313344.1| IpaC [Shigella sonnei Ss046] MEIQNTKSTQILYTDISTKQTQSSSETQKSQNYQQIAAHIPLNVGKNPVLTTTLNDDQLLKLSEQVQHDSEIIARLTDKKMKDLSEMSHTLTPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISDQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKFLGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRTYELNTLSAQQKQNIGRATMDTSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDSITQSRNSTASQIAGNIRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaC mutants cannot invade cultured cells or lyse red blood cells (Terry et al., 2008).
References
Terry et al., 2008: Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD. The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells. Microbial pathogenesis. 2008; 45(4); 282-289. [PubMed: 18656530].