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ipaD from Shigella sonnei Ss046

Victor ID 1606
Gene Name ipaD from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670832
NCBI Protein GI 74314925
Locus Tag SSON_P088
Protein Accession YP_313343.1
Other Database IDs UniProtKB-ID: Q3YTQ4_SHISS
UniRef100: UniRef100_Q3YTQ4
UniRef90: UniRef90_Q03947
UniRef50: UniRef50_Q03947
UniParc: UPI00005AACFB
EMBL: CP000039
EMBL-CDS: AAZ91108.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000102122.
EnsemblGenome_TRS: EBESCT00000103078
EnsemblGenome_PRO: EBESCP00000098938
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P088
eggNOG: NOG27430
HOGENOM: HBG671452
OMA: ISHRELW
ProtClustDB: CLSK2299012
BioCyc: SSON300269:SSO_P088-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 82307
Gene Ending Position 83305
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa machinery; required for entry of bacteria into epithelial cells
DNA Sequence 
>gi|74314838:82307-83305 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
CTCAGAAATGGAGAAAAAGTTTATCTGTATCTGTACATGAGCTTATTGTACTACTCAAAACCTTTACTAA
ATTATCAAAAATACTATTGGCATTACTGTATTTTTGAACTAAAGTTTGAAGATTATTTTTCATTGTTTCA
TCTTCGGCAGAGAATCCGGCATTCCATGCCTGATATTTTGCATTATCTAGCACAACCTCGCCATTTCCAC
CTAGATTATTTAAGCTTTTTAACATATTGTCTATTGGGGTCATGTTTATATTGACAACATATCCCCCGTT
TTTTTTAGATACCTTGCCGATTGTTCCACCTAATTCTGTAAGCCATTTATCTGCTTCTTTCTGACTAACA
GTATTAGTTGCTGGATATAGCGGTTTATCTTCATATTTTTTCTTGAGTTCTTCCAATGCTTTTTTAAGCG
AGTTGACTTGTAATTTCACGGAGTTTCCGTCGTTACCTCCGGGAGAGATCCAGCCGGCAAGACTGGAAAG
AACAGCGCTAAAATCTTGATACATTTGAGTATATGAACTAACGGCATGTTCATATACTTTCAGATACTGT
TCATTAATATCATTGATGGAGTTTGCAATTTTAGCCCACAGTTCTCTATGAGATATCATTTGATCTCCAT
CAAGCTCGGCTTCTTTCGGGGCTGAATGTAATAATTCTCTTGCGTCTTTATTAATTGGATATTCGTTCCT
GGAAAGAATATCCAATAGTTGAGCGGATTTATTTACATCCATGCTAATCTGAGATGAATGTAATGCTATT
TCTTCTAGCGATGTTTTAGTCAACGTTTTTTGTGAAAGCTCTTTCTTTAATGCCTGATTTGTTGTTCTGA
TATTATGAAGGGTGTCGTTGAGCATAGTAAGGGAACTTACAGGATGAGAACTGGTCGTTGTTTTTATATC
AGAATTAACTGTTTCGGTTGATGAACCGTTGGTATTGTTTGGACTGAATGATGAGGTGGAAATACTATTA
GTCAGAGTTGTTATATTCA
Protein Sequence 
>gi|74314925|ref|YP_313343.1| IpaD [Shigella sonnei Ss046] MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKELSQKTLTKTSLEEIALHSSQISMDVNKSAQLLDILSRNEYPINKDARELLHSAPKEAELDGDQMISHRELWAKIANSINDINEQYLKVYEHAVSSYTQMYQDFSAVLSSLAGWISPGGNDGNSVKLQVNSLKKALEELKKKYEDKPLYPATNTVSQKEADKWLTELGGTIGKVSKKNGGYVVNINMTPIDNMLKSLNNLGGNGEVVLDNAKYQAWNAGFSAEDETMKNNLQTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFLHF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaD mutants are completely unable to invade cultured cells or lyse RBCs (Picking et al., 2005).
References
Picking et al., 2005: Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infection and immunity. 2005; 73(3); 1432-1440. [PubMed: 15731041].