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ipaA from Shigella sonnei Ss046

Victor ID 1605
Gene Name ipaA from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670831
NCBI Protein GI 74314924
Locus Tag SSON_P087
Protein Accession YP_313342.1
Other Database IDs UniProtKB-ID: Q3YTQ5_SHISS
UniRef100: UniRef100_Q3YTQ5
UniRef90: UniRef90_P18010
UniRef50: UniRef50_P18010
UniParc: UPI00005AACFA
EMBL: CP000039
EMBL-CDS: AAZ91107.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000101981.
EnsemblGenome_TRS: EBESCT00000102937
EnsemblGenome_PRO: EBESCP00000098797
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P087
eggNOG: NOG25973
HOGENOM: HBG683608
OMA: HENPEND
ProtClustDB: CLSK505037
BioCyc: SSON300269:SSO_P087-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 80397
Gene Ending Position 82298
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa machinery; modulates entry of bacteria into epithelial cells
DNA Sequence 
>gi|74314838:80397-82298 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
TTTAATCCTTATTGATATTCTTTAATACTTTTGATAGGGAAGTGGTTACATCTTTTGCTGCTTTATATAT
ATTATTGTTTTCAGCTGTAATATCATTGTTATTTTTTAAATCAGATATATCATCTGTAAGTAATTCTGCA
GAGGTATCGTCAATTTTTGACAATACCTTGCTGAGGGCGCTAGATACTTCTTTTGCCTTTTCATAGATCG
CATGATTTTTATCAATTGTATCTGCGTTGGTTTCTGTTACGTAGTTTATTGTATTTGCATCTGTAACTTT
TAATTTGTTGTTTATTCTGTGTTCTGTTGTGGATTTTGTAATGTCCTTTGATTTTTCCTGTAACTCTCGT
TCTTGTGTTCCTGATTTAGTTCCAATGAGAGATATAAGATTACTTAGGGAGTTTGTTACTTTTTTTGACG
CTTCAAATATCGTTTCCCGTGTTAAATATGTGTCTCCATTTCTTGAGAAAAAATCAGTCTGAAGTACTTT
TGAATCAGTGTTTGAGTTGAATTTATTGATTTGCGAAGCTACTCTATGAGAAAGAGAAGCGCTACTTTTA
GTTGTATCTGATGAGTTATCATTACTGCTTGTCACTCCTTCCGGGTGGAGAGGGGGGGTGGTTGAAGAGT
TCTGTATGTTCAGAGGCCTGTGTCCCCGAGAAAGAGAGTTATTTGCAGATCTTTCTTGACTACTCGTAGT
TAACAGGTCTGAACCTATTCCATCCGAATTATCTGGAGTATGGTTGAAAACCTTTTCTAAAGCTGAATTA
TTTGCAAATGTCTGGACAGTATCTGATATAGAGTGTGGTAGAACGGAAGTTACTTTTTGAACTAGTGCTC
TTTGTGGATTTAGTAATGAGTTTCCGTTACGGGATAATAGATCGTTTGTCTGAGAAGTAGGAGACTGTGC
ATCATTTTCTGGGTTCTCGTGATAGCTATTGTCATATACTCTGTTGTCAAAAACTCTATTATCGTAAGTT
CTATTATCATTATTTATATGATAGTGAATTACAGGTTGGGATGTTTTCTCATTGGCTCCGGGGGTTGGTC
CGCCATCTGGCATATCTTCGGGAGGTGTAGGGAGGCCATCTTGGATAGGATGCGAATCTTTTATATCTTC
TAAAATATCATTAAGGACTTTTCTCAACAGCTCAGGAAACACGGCTACTGTATTTAAGTCTCTTGACAGT
TTACCTATACCAAATCCTTTACTATCAATAGTATTTTTACGTTGATTGCGCAAACTATCAAAGGCAAGTT
TTGCCTGTGCGTCAACTAAATCATCTAGTTTGAGAGATGAAACAGTTTCATTACTTAACTTTAATTCAGC
AAGAATATTATTCTTGATAAATGATGATACTTCAGTATTGAGGAGTTTTTGTCCCAATGATAAAGCTTCA
CCAGATGTGTGTTGTTGTGCTAATAGTGCAAGTCTGTGCTCAATGTTTTGTCGTAATTGATGGAGTTTCT
TATTCTTTGCCGACCATGGTCCAAAGGCAGAATCTTGGGATAATTTATCTTTTATAATTAGTTCCGAATA
CTGTGCGACAATTTTTTGAAGTCCCTTTTCGTTTTCAAAATTAAGACCATTTTGATGTACTAAGGAGTAC
AAAACATTTGAAAATTCGAGAATCTCGCTTTTGGCATACGCATTCATTGAGTTGGAATAAATGCTTCTTA
ACACATCTTCTTTCCCTGAGGAAGAAAATAAAAAATCAAGACATTTCTGATTAAAAGACGTTGCAAAGCT
TTCTTTTTCAGACACTGATGCTGGTGTTTTTAGAGAAGTTTGCGAACTATGGATATCGGATATTTTGCTT
TTTAACTCGCTGTATTCTGTTGATGATGGTGAAGTTGCCTTATATAAGAATGTTGGCGCTTGAGTATTAT
TTACATTATGCA
Protein Sequence 
>gi|74314924|ref|YP_313342.1| IpaA [Shigella sonnei Ss046] MHNVNNTQAPTFLYKATSPSSTEYSELKSKISDIHSSQTSLKTPASVSEKESFATSFNQKCLDFLFSSSGKEDVLRSIYSNSMNAYAKSEILEFSNVLYSLVHQNGLNFENEKGLQKIVAQYSELIIKDKLSQDSAFGPWSAKNKKLHQLRQNIEHRLALLAQQHTSGEALSLGQKLLNTEVSSFIKNNILAELKLSNETVSSLKLDDLVDAQAKLAFDSLRNQRKNTIDSKGFGIGKLSRDLNTVAVFPELLRKVLNDILEDIKDSHPIQDGLPTPPEDMPDGGPTPGANEKTSQPVIHYHINNDNRTYDNRVFDNRVYDNSYHENPENDAQSPTSQTNDLLSRNGNSLLNPQRALVQKVTSVLPHSISDTVQTFANNSALEKVFNHTPDNSDGIGSDLLTTSSQERSANNSLSRGHRPLNIQNSSTTPPLHPEGVTSSNDNSSDTTKSSASLSHRVASQINKFNSNTDSKVLQTDFFSRNGDTYLTRETIFEASKKVTNSLSNLISLIGTKSGTQERELQEKSKDITKSTTEHRINNKLKVTDANTINYVTETNADTIDKNHAIYEKAKEVSSALSKVLSKIDDTSAELLTDDISDLKNNNDITAENNNIYKAAKDVTTSLSKVLKNINKD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaA mutants are attenuated in invasion of HeLa cells (Tran et al., 1997).
References
Tran et al., 1997: Tran Van Nhieu G, Ben-Ze'ev A, Sansonetti PJ. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin. The EMBO journal. 1997; 16(10); 2717-2729. [PubMed: 9184218].