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ospB from Shigella sonnei Ss046

Victor ID 1602
Gene Name ospB from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670805
NCBI Protein GI 74314841
Locus Tag SSON_P003
Protein Accession YP_313259.1
Other Database IDs UniProtKB-ID: Q3YTY8_SHISS
UniRef100: UniRef100_Q7AY55
UniRef90: UniRef90_Q7AY55
UniRef50: UniRef50_Q7AY55
UniParc: UPI00000BEF8E
EMBL: CP000039
EMBL-CDS: AAZ91024.1
RefSeq_NT: NC_007385.1
EnsemblGenome: EBESCG00000101947.
EnsemblGenome_TRS: EBESCT00000102903
EnsemblGenome_PRO: EBESCP00000098763
GenomeReviews: CP000039_GR
KEGG: ssn:SSON_P003
eggNOG: NOG149380
HOGENOM: HBG210283
OMA: SITATEM
ProtClustDB: CLSK504960
BioCyc: SSON300269:SSO_P003-MONOMER
Taxonomy ID 300269
Plasmid No pSS_046
Gene Starting Position 1175
Gene Ending Position 2041
Gene Strand (Orientation) +
Protein Name protein secreted by the Mxi-Spa secretion machinery
DNA Sequence 
>gi|74314838:1175-2041 Shigella sonnei Ss046 plasmid pSS_046, complete sequence
TATGAATTTAGATGGTGTTAGACCATACTGTAGAATAGTCAATAAAAAGAATGAAAGCATATCAGATATT
GCATTTGCACATATAATAAAAAGGGTAAAAAATTCATCATGTACTCACCCAAAAGCAGCATTGGTTTTTT
TAGGAGAGAAAGGTTTTTGTGATAGCAATGATGTTCTATCTATTATGGGACAACAAATACCAAGAGTATT
TAAGAACAAGATGTTATATGATTATGTTTTTAAAAATGAAAAAAGTAAAAATGATTTTCTAAAAATGGCT
GAATCATGGCTACCACAGAGTGAACCAATAGTAATAAATAATGATGATGACGCATTGAATGCTGCTGCTT
ATTTTTCTGTAAAAAAAGCGAAAATAAAAACAGTAAACGATACTGATTTTAAAGAGTATAATAAGGTTTA
TATTCTTGGGCACGGTAGTCCTGGTTCTCATCAATTAGGCCTTGGTTCGGAACTTATTGATGTACAAACA
ATCATTTCAAGAATGAAAGACTGTGGTATTCTAAATGTGAAAGATATCCGTTTTACTTCATGCGGCTCCG
CTGATAAAGTGGCTCCTAAAAATTTTAACAATGCCCCTGCTGAAAGTCTTTCTTGTATCCTTAACTCTCT
GCCTTTTTTTAAGGAAAAAGAATCTTTGCTAGAGCAGATAAAAAAACACCTTGAAAACGATGAGTCATTG
AGTGATGGTCTAAAAATATCCGGCTATCATGGATATGGAGTTCACTATGGTCAAGAGCTTTTTCCCTACT
CACATTATCGTTCAACTTCAATTCCTGCTGATCCGGAGCATACAGTAAAAAGAAGCTCTCAGAAAAAGAC
TTTTATTATTAATAAAGAACTGGATTA
Protein Sequence 
>gi|74314841|ref|YP_313259.1| OspB [Shigella sonnei Ss046] MNLDGVRPYCRIVNKKNESISDIAFAHIIKRVKNSSCTHPKAALVFLGEKGFCDSNDVLSIMGQQIPRVFKNKMLYDYVFKNEKSKNDFLKMAESWLPQSEPIVINNDDDALNAAAYFSVKKAKIKTVNDTDFKEYNKVYILGHGSPGSHQLGLGSELIDVQTIISRMKDCGILNVKDIRFTSCGSADKVAPKNFNNAPAESLSCILNSLPFFKEKESLLEQIKKHLENDESLSDGLKISGYHGYGVHYGQELFPYSHYRSTSIPADPEHTVKRSSQKKTFIINKELD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospB mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2009).
References
Zurawski et al., 2009: Zurawski DV, Mumy KL, Faherty CS, McCormick BA, Maurelli AT. Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein. Molecular microbiology. 2009; 71(2); 350-368. [PubMed: 19017275].