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phoP from Shigella sonnei Ss046

Victor ID 1594
Gene Name phoP from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3670177
NCBI Protein GI 74311689
Locus Tag SSON_1148
Protein Accession YP_310108.1
Other Database IDs UniProtKB-ID: Q3Z2Y9_SHISS
UniRef100: UniRef100_Q8CXZ9
UniRef90: UniRef90_Q57QC3
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI000000E0F8
EMBL: CP000038
EMBL-CDS: AAZ87873.1
RefSeq_NT: NC_007384.1
EnsemblGenome: EBESCG00000101401.
EnsemblGenome_TRS: EBESCT00000102357
EnsemblGenome_PRO: EBESCP00000098386
GenomeReviews: CP000038_GR
KEGG: ssn:SSON_1148
eggNOG: COG0745
HOGENOM: HBG753323
OMA: HIEEVVA
ProtClustDB: PRK10816
BioCyc: SSON300269:SSO_1148-MONOMER
Taxonomy ID 300269
Gene Starting Position 1229799
Gene Ending Position 1230470
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator in two-component regulatory system with PhoQ
DNA Sequence 
>gi|74310614:1229799-1230470 Shigella sonnei Ss046, complete genome
ATCAGCGCAATTCGAACAAATAGCCCTGGCCGCGAACGGTAGTAATCACTTCTTGCGGATATTGTGCCTG
AATTTTTTTGCGCAGACGTCCCATCAGTACATCAATGGTATGGCTTTCCCGCAGCTCCGCATCCGGATAG
AGTTGGAGCATTAACGAATCTTTGCTCACCACTTTGCCATTATTGCGTATCAACGTTTCCATAATGGTGT
ATTCGAACGCGGTCAGTTTGATCACTTCGTCATTAATAGATAATTCACGGCGAGAGAGATCAACCTGAAA
CGGTGGTAGCGAAATGACCTGTGAAGCCAGACCGCTATTACGCCGCATTAATGCCTGCATTCGCGCCATC
ACCTCTTCAATATGAAATGGTTTAGTCACGTAATCATCAGCACCAGCACTTAATACTTCGACTTTGTCCT
GCCAGCTTTCACGGGCGGTTAATACCAGAATCGGCAGTGAAACATCATTGCTACGCCAGCGGCGAATCAG
TGACAGACCGTCCTCGTCTGGCAATCCGAGATCGACAATCGCAATATCCGGTAAATGTTCATTGAGATAA
TAATCGGCTTCTTTGGCATCTTCTGCATCATCGACCTGATGACCAGCATCCTGAATCTGAACTTTAAGGT
GGTGACGTAACAACGCATTGTCTTCAACAACCAGTACGCGCA
Protein Sequence 
>gi|74311689|ref|YP_310108.1| DNA-binding transcriptional regulator PhoP [Shigella sonnei Ss046] MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants were resolved more quickly than wild type in animal models, and are more susceptible to killing by PMNs (Moss et al., 2000).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Moss et al., 2000: Moss JE, Fisher PE, Vick B, Groisman EA, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular microbiology. 2000; 2(6); 443-452. [PubMed: 11207599].