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guaA from Shigella sonnei Ss046

Victor ID 1584
Gene Name guaA from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3668044
NCBI Protein GI 74313033
Locus Tag SSON_2589
Protein Accession YP_311452.1
Other Database IDs UniProtKB-ID: GUAA_SHISS
UniRef100: UniRef100_Q3YZ45
UniRef90: UniRef90_A7ZPV1
UniRef50: UniRef50_Q3JR65
UniParc: UPI00005AA921
EMBL: CP000038
EMBL-CDS: AAZ89217.1
RefSeq_NT: NC_007384.1
EnsemblGenome: EBESCG00000101659
EnsemblGenome_TRS: EBESCT00000102615
EnsemblGenome_PRO: EBESCP00000098644
GenomeReviews: CP000038_GR
KEGG: ssn:SSON_2589
eggNOG: COG0519
HOGENOM: HBG391775
OMA: MKLVEPL
ProtClustDB: PRK00074
BioCyc: SSON300269:SSO_2589-MONOMER
Taxonomy ID 300269
Gene Starting Position 2734500
Gene Ending Position 2736077
Gene Strand (Orientation) -
Protein Name glutamine-hydrolyzing
DNA Sequence 
>gi|74310614:2734500-2736077 Shigella sonnei Ss046, complete genome
ATCATTCCCACTCAATGGTAGCTGGCGGCTTGCCGCTGATGTCATACACCACGCGGGAAATACCGTTCAC
TTCATTGATAATGCGGTTGGAAACGCGACCGAGGAAATCGTACGGCAGACGCGCCCAGTGTGCGGTCATA
AAGTCGATGGTTTCGACAGCACGCAGAGAGACAACCCAGTCATACTTACGACCATCGCCCATTACGCCAA
CGGAACGTACCGGCAGGAACACAGTGAACGCCTGGCTGACTTTGTCGTACAGGTCCGCTTTACGCAGTTC
TTCAATGAAGATGGCGTCAGCACGGCGCAGCAGGTCACAGTACTCTTTCTTCACTTCACCCAGCACACGA
ACGCCAAGGCCTGGTCCCGGGAATGGGTGACGGTACAACATGTCGTACGGCAGGCCCAGCTCCAGACCAA
TCTTACGCACTTCGTCTTTGAACAGCTCTTTCAGCGGTTCAACCAGGCCCATCTTCATCTCTTTCGGCAG
GCCGCCCACGTTGTGGTGAGATTTGATGACGTGTGCTTTACCGGTTGCAGACGCCGCAGATTCGATAACG
TCAGGGTAGATGGTGCCCTGCGCCAGCCACTTCACGTCTTCCAGTTTCAGCGCTTCTTCATCGAATACTT
CAACGAAAACGCGACCGATGATTTTACGTTTTGCTTCCGGATCGTTTTCGCCAGCCAGCGCTGACAGGAA
GCGATCTTCTGCCGGAACGTGAACAATGTTCAGACCAAAGTGATCGCCAAACATATCCAGAACCTGCTCT
GCTTCGTTGAGACGCAGCAGGCCGTTGTCGACGAATACGCAAGTCAGGTTTTTACCGATAGCGCGGTGCA
GTAGCATTGCGGTTACGGAGGAATCCACGCCACCAGAGAGGCCGAGGATGACTTTATCGTCGCCTACCTG
CTCACGGATGCGGGCTACAGCATCGTCGATAATTTTCGCTGGCGTCCACAGGGCTTCACACTGGCAGATA
TCACGCACAAAACGCTCCAGCATGCGCATACCCTGGCGGGTGTGAGTCACTTCCGGGTGGAACTGTACGC
CATAGAAGCGTTTTTCTTCGTTAGCCATAATGGCAAACGGGCAGCTTTCGGTGCTGGCTACGGTGACGAA
GTCGGACGGGATAGCGGTAACTTTATCGCCGTGGCTCATCCAGACATCGAGCAGCGGTTTACCGTCTGCG
GTCAGCGCATCTTCGATACCGCGAACCAGTGCACTGTCGTTTACGACTTCAACCTGCGCGTAGCCAAATT
CACGTTCGTTAGAGGCTTCAACGTGACCGCCCAACTGCATTGCCATGGTCTGCATGCCATAGCAAACGCC
GAATACCGGTACGCCTGCTTCAAAGACATACTGCGGCGCACGCGGGCTGTTTTCTTCAGTAGTACTTTCC
GGGCCGCCGGAAAGAATAATGCCGCTTGGATTGAAGTCACGAATTTGTGCTTCTGTCACATCCCACGCCC
ACAGTTCGCAGTAAACACCCAGCTCACGCACGCGGCGCGCAACCAGTTGAGTGTACTGAGAACCGAAGTC
TAGAATGAGGATGCGATGCTTATGAATGTTTTCCGTCA
Protein Sequence 
>gi|74313033|ref|YP_311452.1| GMP synthase [Shigella sonnei Ss046] MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWARLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: guaAguaB mutants are attenuated in HeLa cells (Noriega et al., 1996).
COG COG0519F, under F: Nucleotide transport and metabolism
References
Noriega et al., 1996: Noriega FR, Losonsky G, Lauderbaugh C, Liao FM, Wang JY, Levine MM. Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine. Infection and immunity. 1996; 64(8); 3055-3061. [PubMed: 8757833].