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envZ from Shigella sonnei Ss046

Victor ID 1581
Gene Name envZ from Shigella sonnei Ss046
Sequence Strain (Species/Organism) Shigella sonnei Ss046
NCBI Gene ID 3667244
NCBI Protein GI 74313907
Locus Tag SSON_3535
Protein Accession YP_312326.1
Other Database IDs UniProtKB-ID: Q3YWM1_SHISS
UniRef100: UniRef100_P0AEJ4
UniRef90: UniRef90_P0AEJ4
UniRef50: UniRef50_P0AEJ4
UniParc: UPI0000000AFB
EMBL: CP000038
EMBL-CDS: AAZ90091.1
RefSeq_NT: NC_007384.1
EnsemblGenome: EBESCG00000099040.
EnsemblGenome_TRS: EBESCT00000099996
EnsemblGenome_PRO: EBESCP00000096025
GenomeReviews: CP000038_GR
KEGG: ssn:SSON_3535
eggNOG: COG0642
HOGENOM: HBG334875
OMA: KPSYQQI
ProtClustDB: PRK09467
BioCyc: SSON300269:SSO_3535-MONOMER
Taxonomy ID 300269
Gene Starting Position 3697209
Gene Ending Position 3698561
Gene Strand (Orientation) -
Protein Name osmolarity sensor protein
DNA Sequence 
>gi|74310614:3697209-3698561 Shigella sonnei Ss046, complete genome
TTTACCCTTCTTTTGTCGTGCCCTGCGCCCGCGTTACCGGCACTGGCAGCCAGGCGCGAATGGAAAGCCC
GCCCCGCTCGCTGGTGCCAAGCTCCAGCATCCCGTTATGGTTATCCACGATACGCTGCACAATTGCCAGC
CCTAATCCCGTGCCGCTAATGGTGCGCGCACTGTCGCCGCGGACAAACGGCTGGAACAGGTGCTTACGTT
GTTCCGGCGCAATTCCCGGACCGTCATCTTCCACCTGGAACCAGGCGCGATTCGGCTCCGTTCCGCTGCT
GACTTTGATCCAGCCATTGCCATAACGAGCGGCGTTGACCACCATATTCGCCACCGCGCGTTTGATCGAC
AGCGGGTGCATTTTCACTTCAATGCTGCCGGGGTAAAGCGCGGTTTCAATTTCCCGCTCATAGCCACTTT
CGGCAGCAATCACCTCACCGAGCACTGCATTAAGATCCGCCATTTCCATCGGCATCTCCTGCCCGGTGCG
CAGGTAGTCGATAAACTGCTCAATGATGGCGTTGCACTCTTCGATATCTTTATTGATCGATTCTGCCAGA
TAGCCATCCTGCTCGCTCATCATCTCAGTCGCCAGGCGAATACGCGTCAGCGGCGTGCGCAAGTCGTGAC
TTACCCCCGCCATCAGCAGCGTGCGGTCATCCGCCAGTTGCTTAACACCAGCCGCCATATGGTTAAAGGC
GCGGGTAACGGAACGCACCTCGGACGCGCCATACTCACGCAGCGGCGGCGGAATAATCCCTTTACCGACC
TGCAAAGCAGCATGTTCGAGATCGACCAACGGTCGGTTCTGGATACGAATAAACAGCCACGCCCCGCCTA
TCGCCAATAGCATAATCGCCAGCGTATAGCGGAACAGCGGAGAGAAATCGCCCTGATGAATTTCGGTCAG
CGGCACGCGTACCCAGATATTGGGCGACAGCCAGGTTTTCAGCCAGACGACAGGCGAACTTTTGTTGACC
TCAACGCGCACTTCCGTCGGGCCGCCCAGTTGCTGTGCCATCTGATGGCTTAAGAATTCATAGTGTTGCG
CCCAACGCAGACCTGCCTCTTCGGCAGCCTCGTTGGAGTAGAGAGAGATCCCCAGCTCACGGTAGATCTC
CCGACGGAAAGCGGGAGGCACAACCAACTGCGTGCCGTCCTCCAGTTGCAGTTTGTCGGTCATCAACATA
CGCACTTCGTACGCGAGGACTTTATTAAACTGCTGGAGGCTCGGCAAAATCGCGAAGTTCAGCACCACCA
GATAAGTCGTCACCAGGCTGGCGAACAGCAAGGTGACGATGAGCAATAACGTACGGGCAAATGAACTTCG
TGGCGAGAAGCGCAATCGCCTCA
Protein Sequence 
>gi|74313907|ref|YP_312326.1| osmolarity sensor protein [Shigella sonnei Ss046] MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: envZ insertion mutant is able to invade cells but has decreased virulence due to the inability to survive intracellularly (Bernardini et al., 1990).
COG COG0642T, under T: Signal transduction mechanisms
References
Bernardini et al., 1990: Bernardini ML, Fontaine A, Sansonetti PJ. The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri. Journal of bacteriology. 1990; 172(11); 6274-6281. [PubMed: 2121709].