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guaA from Shigella boydii Sb227

Victor ID 1564
Gene Name guaA from Shigella boydii Sb227
Sequence Strain (Species/Organism) Shigella boydii Sb227
NCBI Gene ID 3781514
NCBI Protein GI 82544956
Locus Tag SBO_2531
Protein Accession YP_408903.1
Other Database IDs UniProtKB-ID: GUAA_SHIBS
UniRef100: UniRef100_Q31XY3
UniRef90: UniRef90_A7ZPV1
UniRef50: UniRef50_Q3JR65
UniParc: UPI00005E3FAE
EMBL: CP000036
EMBL-CDS: ABB67075.1
RefSeq_NT: NC_007613.1
EnsemblGenome: EBESCG00000076816
EnsemblGenome_TRS: EBESCT00000077769
EnsemblGenome_PRO: EBESCP00000074916
GenomeReviews: CP000036_GR
KEGG: sbo:SBO_2531
HOGENOM: HBG391775
OMA: MKLVEPL
ProtClustDB: PRK00074
BioCyc: SBOY300268:SBO_2531-MONOMER
Taxonomy ID 300268
Gene Starting Position 2526680
Gene Ending Position 2528257
Gene Strand (Orientation) -
Protein Name glutamine-hydrolyzing
DNA Sequence 
>gi|82542618:2526680-2528257 Shigella boydii Sb227, complete genome
ATCATTCCCACTCAATGGTAGCTGGCGGCTTGCCGCTGATGTCATACACCACGCGGGAAATACCGTTCAC
TTCATTGATAATGCGGTTGGAAACGCGACCGAGGAAATCGTACGGCAGATGCGCCCAGTGTGCGGTCATA
AAGTCGATGGTTTCGACAGCACGCAGAGAGACAACCCAGTCATACTTACGACCATCGCCCATTACGCCAA
CGGAACGTACCGGCAGGAACACAGTGAACGCCTGGCTGACTTTGTCGTACAGGTCCGCTTTACGCAGTTC
TTCAATGAAGATGGCGTCAGCACGGCGCAGCAGGTCACAGTACTCTTTCTTCACTTCACCCAGCACACGA
ACGCCAAGGCCTGGTCCCGGGAACGGGTGACGGTACAGCATGTCGTACGGCAGGCCCAGCTCCAGACCAA
TCTTACGCACTTCGTCTTTGAACAGCTCTTTCAGCGGTTCAACCAGGCCCATCTTCATCTCTTTCGGCAG
GCCGCCCACGTTGTGGTGAGATTTGATGACGTGTGCTTTACCGGTTGCAGAAGCCGCAGATTCGATAACG
TCAGGGTAGATGGTGCCCTGCGCCAGCCACTTCACGTCTTCCAGTTTCAGCGCTTCTTCATCGAACACTT
CAACGAAAACGCGCCCGATGATTTTACGTTTTGCTTCCGGATCGTTTTCGCCAGCCAGCGCTGACAGGAA
GCGATCTTCTGCCGGTACGTGAACAATGTTCAGACCAAAGTGATCGCCAAACATATCCAGAACCTGCTCT
GCTTCGTTGAGACGCAGCAGGCCGTTGTCGACGAATACGCAAGTCAGATTTTTACCGATAGCGCGGTGCA
GCAGCATTGCGGTTACGGAGGAATCCACACCACCAGAGAGGCCGAGGATGACTTTATCGTCGCCTACCTG
CTCGCGGATGCGAGCTACAGCATCGTCGATAATTTTCGCTGGCGTCCACAGGGCTTCACACTGGCAGATA
TCACGCACAAAACGCTCCAGCATGTGCATACCCTGGCGGGTGTGAGTCACTTCCGGGTGGAACTGTACGC
CATAGAAGCGTTTTTCTTCGTTAGCCATAATGGCAAACGGGCAGCTTTCGGTGCTGGCTACGGTGACGAA
GTCGGACGGGATAGCGGTAACTTTATCGCCGTGGCTCATCCAGACATCGAGCAGCGGTTTACCGTCTGCG
GTCAGCGCATCTTCGATACCGCGAACCAGTGCGCTGTCGTTTACGACTTCAACCTGCGCGTAGCCAAATT
CACGTTCGTTAGAGGCTTCAACGTGACCGCCCAACTGCATTGCCATGGTCTGCATGCCATAGCAAACGCC
GAATACCGGTACGCCTGCTTCAAAGACATACTGCGGCGCACGCGGACTGTTTTCTTCAGTAGTACTTTCC
GGGCCGCCGGAAAGAATAATGCCGCTTGGATTGAAGTCACGAATTTGTGCTTCTGTCACATCCCACGCCC
ACAGTTCGCAGTAAACACCCAGCTCACGCACGCGGCGCGCAACCAGTTGAGTGTACTGAGAACCGAAGTC
CAGAATGAGGATGCGATGCTTATGAATGTTTTCCGTCA
Protein Sequence 
>gi|82544956|ref|YP_408903.1| GMP synthase [Shigella boydii Sb227] MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMHMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: guaAguaB mutants are attenuated in HeLa cells (Noriega et al., 1996).
COG COG0519F, under F: Nucleotide transport and metabolism
References
Noriega et al., 1996: Noriega FR, Losonsky G, Lauderbaugh C, Liao FM, Wang JY, Levine MM. Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine. Infection and immunity. 1996; 64(8); 3055-3061. [PubMed: 8757833].