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ospC1 from Shigella boydii Sb227

Victor ID 1553
Gene Name ospC1 from Shigella boydii Sb227
Sequence Strain (Species/Organism) Shigella boydii Sb227
NCBI Gene ID 3776825
NCBI Protein GI 82524740
Locus Tag SBO_P077
Protein Accession YP_406301.1
Other Database IDs UniProtKB-ID: Q31SK9_SHIBS
UniRef100: UniRef100_B2TST5
UniRef90: UniRef90_B2TST5
UniRef50: UniRef50_Q3YTS0
UniParc: UPI00001D8F9F
EMBL: CP000037
EMBL-CDS: ABB68949.1
RefSeq_NT: NC_007608.1
EnsemblGenome: EBESCG00000079313.
EnsemblGenome_TRS: EBESCT00000080266
EnsemblGenome_PRO: EBESCP00000077247
GenomeReviews: CP000037_GR
KEGG: sbo:SBO_P077
HOGENOM: HBG683600
OMA: SIANQKE
ProtClustDB: CLSK504963
BioCyc: SBOY300268:SBO_P077-MONOMER
Taxonomy ID 300268
Plasmid No pSB4_227
Gene Starting Position 61626
Gene Ending Position 63038
Gene Strand (Orientation) -
Protein Name secreted by the Mxi-Spa secretion machinery, function unknown
DNA Sequence 
>gi|82524664:61626-63038 Shigella boydii Sb227 plasmid pSB4_227, complete sequence
ATTAAATATATTTATTGTCAGATGTTGCACCATATTTCAATAATAGTTTTATCATTTCTGCATTCTCATA
TTTTATTGCGTTATCCAACATACAATCCCCACTATTAGTTTTTTTGAACTTTGTGTTTACATCAACCAAT
CCCTTATTGATAAAATACTCAAGTACTTTACAGCTTGAATTATGAGCGCTAAGTAGATACTCAATATCAT
ACAACTCATGCTTTATGGAAATAACATCTTGTCTAGTTATCTCAAAATTAGATAATATATATAAGGCGAC
ATCCTCTTTTTGATTAGTAATCGAAAGAAAAAGAGTCTGGAGAGCAATTTTTTTGTTAGTGACCTGCTTG
TTAATTTCTTCGTAATTAGATGCTGTAACAGCCTCCTCTAAGGATATTTCTCTAATCTTAACTTTTTTGA
AGTTTTCTGTACTTACCATCCTAGGTATATGGTACTCTGGCTGAAAAACAAAGTTTATGATTCTATCCAG
ATCCACAGGGGCAAGATTTTTTCCATAGCAAAACTCCTTGAAGCTTTGGTCTTCACTTTTTCTAATAAAG
TCAATCAGGTATAATCCGAGCCCTAACTTCATATCTTTAGTATTGAATATTGGTACATCTATAATTCCTT
TACTTCCATGTACGTATCGACTAACTTCTTTATTAACCTCTGAAAATTTATCTAAAAATGATTGGTGCTC
ATGGTAAAAAACAGGTGGAATAGCATTATCAAAGTGATCGGTTAATGTCATATATCCATATGGAGAGTCA
TGATCAATGATATACGCATTTGCACCAAAATCAACAGTGTGATGTTTTGTATTCAGGGGGTGTTTTTTCT
GATGGCTAGAGATTTCAACGCCAAAAAACACAAAGTCATGATTAGCTATTTTTTTTATATCATCAGCGTA
TGTGTTTCGTTTTGTGCATATTCCTTCAGACTGAATTTTATTGAATGACTTAATGTTTAAAATTTTATCA
GACAAATCAGAATTACTTTGATGTCTGAAGATTAAATCAGAATTAATAATTAGCGAAAGCAAATTGAGTT
CCTCTGCAGAAAGAGGATGAAGTTTTTCCCTTATTTCAGATATATAATGCTTCGATAATCTGTCAAGGTG
CTCAATAGCCTTAAATGAGGCTTTAGCGTCTGATGGTGCATCAATTGCTATATTTAAAGATTTAAAGTTA
GAGCCTTGAGAGAACATTCTACTATAACTTTGTGCTGCTATAGTTTTCCTAAAGAAATCTTTAATAATAT
TTGCACTATCTTTTAAATTTTTTTCATCTGGCATAGTTTGTTGTGCAGCGTTTCGCACTGATGTCACTTT
TGGAAACAATGTATGTAATCTGTTATCCATAGAATCTATATTGCATTGGGTATTTGCTGAGTTCAGTGTT
TCTGATATATTCA
Protein Sequence 
>gi|82524740|ref|YP_406301.1| OspC1 [Shigella boydii Sb227] MNISETLNSANTQCNIDSMDNRLHTLFPKVTSVRNAAQQTMPDEKNLKDSANIIKDFFRKTIAAQSYSRMFSQGSNFKSLNIAIDAPSDAKASFKAIEHLDRLSKHYISEIREKLHPLSAEELNLLSLIINSDLIFRHQSNSDLSDKILNIKSFNKIQSEGICTKRNTYADDIKKIANHDFVFFGVEISSHQKKHPLNTKHHTVDFGANAYIIDHDSPYGYMTLTDHFDNAIPPVFYHEHQSFLDKFSEVNKEVSRYVHGSKGIIDVPIFNTKDMKLGLGLYLIDFIRKSEDQSFKEFCYGKNLAPVDLDRIINFVFQPEYHIPRMVSTENFKKVKIREISLEEAVTASNYEEINKQVTNKKIALQTLFLSITNQKEDVALYILSNFEITRQDVISIKHELYDIEYLLSAHNSSCKVLEYFINKGLVDVNTKFKKTNSGDCMLDNAIKYENAEMIKLLLKYGATSDNKYI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ospC1 mutants had reduced PMN transepithelial migration when compared to wild-type infection, PMN transepithelial migration is necessary for virulence of Shigella (Zurawski et al., 2006).
References
Zurawski et al., 2006: Zurawski DV, Mitsuhata C, Mumy KL, McCormick BA, Maurelli AT. OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence. Infection and immunity. 2006; 74(10); 5964-5976. [PubMed: 16988276].